2013
DOI: 10.1007/s00467-012-2386-3
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Kidney–lung cross-talk and acute kidney injury

Abstract: There is a growing appreciation for the role that acute kidney injury (AKI) plays in the propagation of critical illness. In children, AKI is not only an independent predictor of morbidity and mortality, but is also associated with especially negative outcomes when concurrent with acute lung injury (ALI). Experimental data provide evidence that kidney–lung crosstalk occurs and can be bidirectionally deleterious, although details of the precise molecular mechanisms involved in the AKI–ALI interaction remain inc… Show more

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Cited by 87 publications
(70 citation statements)
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“…In addition, AKI was independently associated with longer oxygen need/exposure. These findings support previous studies done in animals and adults which showed an association between AKI and acute liver injury [13, 14, 18, 19]. …”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…In addition, AKI was independently associated with longer oxygen need/exposure. These findings support previous studies done in animals and adults which showed an association between AKI and acute liver injury [13, 14, 18, 19]. …”
Section: Discussionsupporting
confidence: 93%
“…Although the precise molecular mechanisms are not fully understood [13], animal models have provided evidence for a deleterious impact of bidirectional kidney–lung injury [1417]. For example, in 2008 Grigory et al showed that after ischemic AKI, mice had an inflammatory response in the lung which paralleled that found in the kidney [14].…”
Section: Introductionmentioning
confidence: 99%
“…[41, 42] The mechanisms or mediators of these effects are far from clear but likely include inflammatory mediators that either directly or indirectly inflict pathological change. It is exciting to try to imagine FGF23 as one of these mediators, since FGF23 has been linked epidemiologically with adverse distant organ effects in CKD and dialysis patients (for example, with cardiovascular mortality) and mechanistically with ventricular hypertrophy.…”
Section: Resultsmentioning
confidence: 99%
“…Hypoxemia and acute lung injury due to respiratory failure leads to a decrease in renal blood flow and is a risk factor for AKI. [31, 32] Understanding the pathophysiology of ACS in context of AKI could explain part of the severity of this disease and prolonged need for respiratory support.…”
Section: Discussionmentioning
confidence: 99%