Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications

Tomaszewski, Maciej; Morris, Andrew P.; Howson, Joanna M. M.; Franceschini, Nora; Eales, James; Xu, Xiaoguang; Dikalov, Sergey; Guzik, Tomasz J.; Humphreys, Benjamin D.; Harrap, Stephen; Charchar, Fadi J.

doi:10.1016/j.kint.2022.04.045

Cited by 18 publications

(21 citation statements)

References 119 publications

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“…STEP 5: Trim and optimise the causality network based on biological facts53; this will probably generate a causality chain (ie, the causal biological pathway) starting with genetic signals or other biophenotypes and pointing to the end of the core symptom.…”

Section: How Brain Science Could Help Decode Psychosismentioning

confidence: 99%

Decoding psychosis: from national genome project to national brain project

Sun

Shi

et al. 2022

Gen Psych

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The mind has puzzled humans for centuries, and its disorders, such as psychoses, have caused tremendous difficulties. However, relatively recent biotechnological breakthroughs, such as DNA technology and neuroimaging, have empowered scientists to explore the more fundamental aspects of psychosis. From searching for psychosis-causing genes to imaging the depths of the brain, scientists worldwide seek novel methods to understand the mind and the causes of its disorders. This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science.

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Section: How Brain Science Could Help Decode Psychosismentioning

confidence: 99%

Decoding psychosis: from national genome project to national brain project

Sun

Shi

et al. 2022

Gen Psych

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“…Blood pressure is controlled by various mechanisms, including short- medium- and long-term mechanisms ( Ahmed et al, 2020 ; 2021; de Bhailis and Kalra, 2022 ; Tomaszewski et al, 2022 ). CSK has been shown to engage in blood pressure regulation and CSK depletion has been identified as a possible trigger for hypertension ( Lee et al, 2016 ; Oh et al, 2018 ).…”

Section: Clinical Importance Of Tyrosine-protein Kinase Cskmentioning

confidence: 99%

Apoptosis regulation by the tyrosine-protein kinase CSK

Fortner

Chera

Tanca

et al. 2022

Front. Cell Dev. Biol.

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C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. Current knowledge on the CSK mechanisms of action, regulation and functions is still at an early stage, most of CSK’s known actions and functions being mediated by the negative regulation of the SRC family of tyrosine kinases (SFKs) through phosphorylation. As SFKs play a vital role in apoptosis, cell proliferation and survival regulation, SFK inhibition by CSK has a pro-apoptotic effect, which is mediated by the inhibition of cellular signaling cascades controlled by SFKs, such as the MAPK/ERK, STAT3 and PI3K/AKT signaling pathways. Abnormal functioning of CSK and SFK activation can lead to diseases such as cancer, cardiovascular and neurological manifestations. This review describes apoptosis regulation by CSK, CSK inhibition of the SFKs and further explores the clinical relevance of CSK in important pathologies, such as cancer, autoimmune, autoinflammatory, neurologic diseases, hypertension and HIV/AIDS.

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“…Due to the cellular heterogeneity of the focal organs, single cell resolution research is needed. Using the single-cell omic methodology, scientists could map disease-associated SNPs or genes to cell types at the single-cell level, reveal the heterogeneity among cells at multiple omic levels and elucidate their different omic associations or variations, which would provide new directions for functional genetic research in human diseases and animal models ( Timshel et al, 2020 ; Tomaszewski et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Single-cell omics: A new direction for functional genetic research in human diseases and animal models

Kong

Tian

et al. 2023

Front. Genet.

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Over the past decade, with the development of high-throughput single-cell sequencing technology, single-cell omics has been emerged as a powerful tool to understand the molecular basis of cellular mechanisms and refine our knowledge of diverse cell states. They can reveal the heterogeneity at different genetic layers and elucidate their associations by multiple omics analysis, providing a more comprehensive genetic map of biological regulatory networks. In the post-GWAS era, the molecular biological mechanisms influencing human diseases will be further elucidated by single-cell omics. This review mainly summarizes the development and trend of single-cell omics. This involves single-cell omics technologies, single-cell multi-omics technologies, multiple omics data integration methods, applications in various human organs and diseases, classic laboratory cell lines, and animal disease models. The review will reveal some perspectives for elucidating human diseases and constructing animal models.

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Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications

Cited by 18 publications

References 119 publications

Decoding psychosis: from national genome project to national brain project

Decoding psychosis: from national genome project to national brain project

Apoptosis regulation by the tyrosine-protein kinase CSK

Single-cell omics: A new direction for functional genetic research in human diseases and animal models

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