Kidney Preservation

Jochmans, Ina; O’Callaghan, John; Ploeg, Rutger J.; Pirenne, Jacques

doi:10.1016/b978-0-12-801734-0.00007-2

Cited by 2 publications

(2 citation statements)

References 121 publications

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“…Organ preservation solutions have been developed to counteract the detrimental consequences of hypothermia and anoxia, namely interstitial and cellular edema, acidosis, and reactive oxygen species (ROS) production at reperfusion. The most defining characteristics of these solutions are their impermeants (usually colloids, saccharides, or anions) and electrolyte composition (either an intracellular [low Na + , high K + ] or an extracellular electrolyte composition [high Na + , low K + ]) 1 …”

Section: Introductionmentioning

confidence: 99%

The effect of IGL-1 preservation solution on outcome after kidney transplantation: A retrospective single-center analysis

Beule

Fieuws

Monbaliu

et al. 2021

American Journal of Transplantation

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Institut Georges Lopez‐1 (IGL‐1) solution is increasingly used for kidney preservation, although little information on outcomes is available. Outcomes of all deceased donor kidneys preserved by IGL‐1, University of Wisconsin solution (UW), or histidine‐tryptophan‐ketoglutarate (HTK) and transplanted in our center (2000‐2018) were analyzed. Multivariable analysis for delayed graft function (DGF), functional DGF, estimated glomerular filtration rate (eGFR, CKD‐EPI equation), proteinuria, acute rejection, death‐censored graft loss, and patient survival were performed. A double robust approach, consisting of propensity score weighting and correction for confounders, minimized the risk of bias. In total, 1943 transplants were included: 234 with IGL‐1, 1046 with UW, and 663 with HTK. As IGL‐1 was only introduced in 2014, a prespecified sensitivity analysis of 917 kidneys (2010‐2018) was performed using the same statistical approach. After weighting, IGL‐1 retained a higher proportion of kidneys donated after circulatory death (DCD). IGL‐1 was not independently associated with any of the outcomes when compared to UW or HTK. Sensitivity analysis between 2010 and 2018 showed similar results. In this retrospective analysis, using robust methodology to reduce the risk of bias, IGL‐1 preservation results in equal outcomes compared to UW or HTK, despite more DCD transplants in the IGL‐1 group.

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Section: Introductionmentioning

confidence: 99%

The effect of IGL-1 preservation solution on outcome after kidney transplantation: A retrospective single-center analysis

Beule

Fieuws

Monbaliu

et al. 2021

American Journal of Transplantation

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“…[4] Each preservation solution has its own unique mix of components that counteract interstitial and cellular edema, cellular acidosis and production of reactive oxygen species. [5] To the current day, the University of Wisconsin (UW) solution remains the gold standard solution against which all others are measured.…”

Section: Introductionmentioning

confidence: 99%

IGL-1 preservation solution in kidney and pancreas transplantation: A systematic review

2020

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We aimed to systematically review published data on the effectiveness of Institut Georges Lopez-1 (IGL-1) as a preservation solution for kidney and pancreas grafts. A systematic literature search of PubMed, Embase, Web of Science, and the Cochrane Library databases was performed. Human studies evaluating the effects of IGL-1 preservation solution in kidney and/or pancreas transplantation were included. Outcome data on kidney and pancreas graft function were extracted. Of 1513 unique articles identified via the search strategy, four articles could be included in the systematic review. Of these, two retrospective studies reported on the outcome of IGL-1 compared to University of Wisconsin (UW) solution in kidney transplantation. These show kidneys preserved in IGL-1 had improved early function (2 weeks post-transplant) compared to UW. Follow-up was limited to 1 year and showed similar graft and patient survival rates when reported. Two case series described acceptable early outcomes (up to 1 month) of simultaneous kidney pancreas transplantation after storage in IGL-1. As only four clinical papers were identified, we widened our search to include four eligible large animal studies. Three compared IGL-1 with UW in pig kidney transplant models with inconclusive or mildly positive results. One pig pancreas transplant study suggested better early outcome with IGL-1 compared to UW. Too few published data are available to allow any firm conclusions to be drawn on the effectiveness of IGL-1 as a preservation solution of kidney and pancreas grafts. The limited available data show satisfactory early outcomes though no medium to long-term outcomes have been described. Further well-designed clinical studies are needed.

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Kidney Preservation

Cited by 2 publications

References 121 publications

The effect of IGL-1 preservation solution on outcome after kidney transplantation: A retrospective single-center analysis

The effect of IGL-1 preservation solution on outcome after kidney transplantation: A retrospective single-center analysis

IGL-1 preservation solution in kidney and pancreas transplantation: A systematic review

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