Kidney Preservation: Review of Present and Future Perspective

Catena, Fausto; Catena, Fausto; Montori, Giulia; Vallicelli, Carlo; Amaduzzi, A.; Ercolani, Giorgio; Ravaioli, Matteo; Gaudio, Massimo Del; Schiavina, R.; Brunocilla, Eugenio; Liviano, G.; Feliciangeli, G.; Pinna, Antonio D.

doi:10.1016/j.transproceed.2013.02.145

Cited by 24 publications

(19 citation statements)

References 45 publications

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“…In addition, other factors that cannot be disregarded are the concomitant use of MP with a perfusion solution, which is well recognized as more efficient than Euro Collins, such as KPS‐1, the control group used Euro Collins solution for preservation, which is associated with higher DGF rate . The Euro Collins solution is used even less in US and European centers, but it is still commonly used in Brazil because of its lower cost . The use of this solution is considered another reason that may contribute to our high rates of DGF.…”

Section: Discussionmentioning

confidence: 99%

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Impact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital discharge

Matos

Requião-Moura

Borrelli

et al. 2017

Clinical Transplantation

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Delayed graft function (DGF) is very high in our center (70%-80%), and we usually receive a kidney for transplant after more than 22 hours of static cold ischemia time (CIT). Also, there is an inadequate care of the donors, contributing to a high rate of DGF. We decided to test whether machine perfusion (MP) after a CIT improved the outcome of our transplant patients. We analyzed the incidence of DGF, its duration, and the length of hospital stay (LOS) in patients who received a kidney preserved with MP after a CIT (hybrid perfusion-HP). We included 54 deceased donors kidneys preserved with HP transplanted from Feb/13 to Jul/14, and compared them to 101 kidney transplants preserved by static cold storage (CS) from Nov/08 to May/12. The median pumping time was 11 hours. DGF incidence was 61.1% vs 79.2% (P = .02), median DGF duration was 5 vs 11 days (P < .001), and median LOS was 13 vs 18 days (P < .011), for the HP compared to CS group. The observed reduction of DGF with machine perfusion did not occur in donors over 50 years old. In the multivariate analysis, risk factors for DGF, adjusted for CIT, were donor age (OR, 1.04; P = .005) and the absence of use of MP (OR, 1.54; P = .051). In conclusion, the use of HP contributed to faster recovery of renal function and to a shorter length of hospital stay. K E Y W O R D Sdelayed graft function, kidney (allograft) function/dysfunction, organ perfusion and preservation

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Section: Discussionmentioning

confidence: 99%

“…[31][32][33] The Euro Collins solution is used even less in US and European centers, but it is still commonly used in Brazil because of its lower cost. 34 The use of this solution is considered another reason that may contribute to our high rates of DGF.…”

Section: Discussionmentioning

confidence: 99%

Impact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital discharge

Matos

Requião-Moura

Borrelli

et al. 2017

Clinical Transplantation

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“…It is observed that UW produced results similar to those of HTK (Salehi et al 2006) and better outcomes than Celsior solution (Hubert et al 2007). For kidney transplantation, the UW solution provides good results in short-and longterm tissue preservation (Xiaodong & Ashok 2010, Catena et al 2013. IGL1 exhibits similar positive outcomes as UW (Codas et al 2009) or even better (Badet et al 2005).…”

Section: Preservation Solutionsmentioning

confidence: 99%

Potential benefits of melatonin in organ transplantation: a review

Esteban‐Zubero

García-Gil

López-Pingarrón

et al. 2016

Journal of Endocrinology

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Organ transplantation is a useful therapeutic tool for patients with end-stage organ failure; however, graft rejection is a major obstacle in terms of a successful treatment. Rejection is usually a consequence of a complex immunological and nonimmunological antigen-independent cascade of events, including free radical-mediated ischemia-reperfusion injury (IRI). To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. Melatonin (N-acetyl-5-methoxytryptamine) is a powerful antioxidant and ant-inflammatory agent synthesized from the essential amino acidl-tryptophan; it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. Melatonin has proven to be a potentially useful therapeutic tool in the reduction of graft rejection. Its benefits are based on its direct actions as a free radical scavenger as well as its indirect antioxidative actions in the stimulation of the cellular antioxidant defense system. Moreover, it has significant anti-inflammatory activity. Melatonin has been found to improve the beneficial effects of preservation fluids when they are enriched with the indoleamine. This article reviews the experimental evidence that melatonin is useful in reducing graft failure, especially in cardiac, bone, otolaryngology, ovarian, testicular, lung, pancreas, kidney, and liver transplantation.

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“…Static cold storage with University of Wisconsin solution remains the most common practice worldwide for limiting ischemia and reperfusion injury before deceased-donor kidney transplantation [27]. A recent meta-analysis of 15 trials examining 3584 kidney transplants systematically examined only comparative prospective studies for deceased-donor renal allografts [28 & ].…”

Section: Kidneymentioning

confidence: 99%