Kidney Preservation With University of Wisconsin and Celsior Solution: A Prospective Multicenter Randomized Study

Faenza, Alessandro; Catena, Fausto; Nardo, Bruno; Montalti, Roberto; Capocasale, E.; Busi, N.; Boggi, Ugo; Vistoli, Fabio; Naro, A Di; Albertazzi, A; Mosca, Franco; Cavallari, Antonino

doi:10.1097/00007890-200110150-00016

Cited by 79 publications

(52 citation statements)

References 16 publications

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“…At the same time, the need to extend donor criteria in light of organ shortage further increases the risk for delayed graft function. Several approaches have already been taken to reduce early graft dysfunction, including optimization of the perfusion fluid (7,8) and the use of pharmaceuticals that interact with single steps in the pathogenesis of ischemia reperfusion injury (9). We reasoned that an effective way to improve early and possibly late graft function could be the induction of an array of endogenous protective mechanisms before the initiation of the acute injury associated with transplantation.…”

mentioning

confidence: 99%

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Bernhardt

Göttmann

Doyon

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

133

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mentioning

confidence: 99%

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Bernhardt

Göttmann

Doyon

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

133

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“…In accordance with other authors, we did not find any differences in the rates of immediate graft function, acute rejection, or graft function in the short-and long-term. 2,7,8 Graft and patient survivals were also similar, letting us conclude that UW and Celsior solutions have the same profile of efficacy in cold storage and kidney preservation. Celsior has the advantage of being an appropriate solution for intrathoracic and liver preservation, organs that we routinely harvest in our hospital.…”

Section: Discussionmentioning

confidence: 57%

Efficacy of Renal Preservation: Comparative Study of Celsior and University of Wisconsin Solutions

Nunes

Mota

Figueiredo

et al. 2007

Transplantation Proceedings

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Objective. We sought to compare the efficacy of Celsior and University of Wisconsin (UW) solutions on the perfusion and cold storage of renal grafts for human transplantation. Patients and Methods. Retrospective analyses of 313 kidney transplants were performed between 2002 and 2005; group A (n ϭ 160), UW solution and group B (n ϭ 153), Celsior solution were used in the preservation of the organs. The mean donor age was lower in group B (group A ϭ 42.67 years vs group B ϭ 38.96 years; P Ͻ .05), living donors were more frequent in the UW group (group A ϭ 10% vs group B ϭ 0.9%; P Ͻ .001). Multiorgan procurement procedures were more common in the Celsior group (group A ϭ 75% vs group B ϭ 81.7%; P Ͻ .001). Recipients with no associated comorbidities were more frequent in the UW group (group A ϭ 50% vs group B ϭ 36%; P Ͻ .001). Recipient mean age, cold ischemia time, and HLA matches were comparable. Results. Delayed graft function (group A ϭ 22.7% vs group B ϭ 20.6%), acute rejections (group A ϭ 21.4% vs group B ϭ 18.4%), and serum creatinine at 6 months (group A ϭ 1.75 vs group B ϭ 1.67 mg/dL), 1 year (group A ϭ 1.47 vs group B ϭ 1.74 mg/dL), and 2 years (group A ϭ 1.43 vs group B ϭ 1.58 mg/dL) showed no differences (P ϭ NS). Graft (group A ϭ 82.23% vs group B ϭ 84.11%) and patient (group A ϭ 93% vs group B ϭ 93.69%) survivals at 3 years were similar (P ϭ NS). There were no differences in the causes of graft loss. Conclusion. The efficacy of UW and Celsior solutions is equivalent in the cold storage and renal preservation for transplantation.

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“…Furthermore, peak lipase on postoperative day 1, serum amylase and C-reactive protein were not significantly different between the two groups. Some reports, including the one by Becker et al Celsior, an extracellular, low-viscosity preservation solution originally designed for heart transplantation has also been used for experimental pancreas [23][24][25] and other organ preservation [26][27][28][29][30][31][32]. For whole-pancreas transplantation, the use of Celsior has been controversial [23][24][25].…”

Section: Pancreas Preservation For Pancreas Transplantationmentioning

confidence: 99%

Pancreas preservation for pancreas and islet transplantation

Iwanaga

Sutherland

Harmon

et al. 2008

Current Opinion in Organ Transplantation

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Purpose of review-To summarize advances and limitations in pancreas procurement and preservation for pancreas and islet transplantation, and review advances in islet protection and preservation.Recent findings-Pancreases procured after cardiac death, with in-situ regional organ cooling, have been successfully used for islet transplantation. Colloid-free Celsior and histidinetryptophan-ketoglutarate preservation solutions are comparable to University of Wisconsin solution when used for cold storage before pancreas transplantation. Colloid-free preservation solutions are inferior to University of Wisconsin solution for pancreas preservation prior to islet isolation and transplantation. Clinical reports on pancreas and islet transplants suggest that the two-layer method may not offer significant benefits over cold storage with the University of Wisconsin solution: improved oxygenation may depend on the graft size; benefits in experimental models may not translate to human organs. Improvements in islet yield and quality occurred from pancreases treated with inhibitors of stress-induced apoptosis during procurement, storage, isolation or culture. Pancreas perfusion may be desirable before islet isolation and transplantation and may improve islet yields and quality. Methods for real-time, noninvasive assessment of pancreas quality during preservation have been implemented and objective islet potency assays have been developed and validated. These innovations should contribute to objective evaluation and establishment of improved pancreas preservation and islet isolation strategies.Summary-Cold storage may be adequate for preservation before pancreas transplants, but insufficient when pancreases are processed for islets or when expanded donors are used. Supplementation of cold storage solutions with cytoprotective agents and perfusion may improve pancreas and islet transplant outcomes.

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Kidney Preservation With University of Wisconsin and Celsior Solution: A Prospective Multicenter Randomized Study

Cited by 79 publications

References 16 publications

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Efficacy of Renal Preservation: Comparative Study of Celsior and University of Wisconsin Solutions

Pancreas preservation for pancreas and islet transplantation

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