Kidney-sparing Management Versus Nephroureterectomy for Upper Tract Urothelial Carcinoma: a Systematic Review and Meta-analysis

Luo, Yilun; She, Dong-Li; Xiong, Hu; Fu, Shengjun; Yang, Li

doi:10.7314/apjcp.2015.16.14.5907

Cited by 10 publications

(2 citation statements)

References 45 publications

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“…In keeping with that, the indications for PU might be extended to selected cases of high-grade or invasive UTUC tumors. As the top-level clinical evidence, another two papers include a systematic review and a meta-analysis comparing PU with RNU [ 27 , 30 ]. As a result, these studies collectively suggest that kidney-sparing management had similar effects on prognosis on UTUC as the standard nephroureterectomy.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma

Zhang

Yang

Wang

et al. 2018

BioMed Research International

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This study aimed to compare the oncological and renal outcomes of partial ureterectomy (PU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). UTUC patients' clinical information was reviewed, and progression-free survival (PFS), overall survival (OS), and kidney function were collected. The mean follow-up period was 59 (6–135) months in the RNU group and 34.5 (5–135) months in the PU group. The mean operation time in the PU group was 141 (64–340) min, which is significantly shorter than the RNU group (P < 0.01). Regarding kidney function at one year or two years after operation, the PU group had significantly improved mean estimated glomerular filtration rate (eGFR) levels and a remarkably decreased constitution of patients with chronic kidney disease (CKD) III or higher group (P < 0.05). There was no significant difference in PFS and OS between the RNU group and the PU group (P > 0.05). Multifactor Cox regression analysis indicated that age and the preoperative CKD stages were independent risk factors for poor kidney functions of UTUC patients. Compared to patients in RNU group, patients in PU have no significant difference in survival time but have shorter operation time, shorter hospital stay, and improved kidney functions.

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Section: Discussionmentioning

confidence: 99%

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma

Zhang

Yang

Wang

et al. 2018

BioMed Research International

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“…While the standard therapy for UTUC used to be radical nephroureterectomy (RNU), kidney-sparing surgeries (KSS) have emerged as an alternative and are increasingly being utilized. KSS includes endoscopic management, such as ureteroscopy or a percu-taneous approach, as well as segmental ureterectomy that preserves the ipsilateral renal unit [2].…”

Section: Introductionmentioning

confidence: 99%

Upper Tract Urothelial Carcinoma (UTUC) Diagnosis and Risk Stratification: A Comprehensive Review

Bitaraf,

Ghafoori Yazdi,

Amini

2023

Cancers

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Diagnosis and risk stratification are cornerstones of therapeutic decisions in the management of patients with upper tract urothelial carcinoma (UTUC). Diagnostic modalities provide data that can be integrated, to provide nomograms and stratification tools to predict survival and adverse outcomes. This study reviews cytology, ureterorenoscopy and the novel tools and techniques used with it (including photodynamic diagnosis, narrow-band imaging, optical coherence tomography, and confocal laser endomicroscopy), and biopsy. Imaging modalities and novel biomarkers are discussed in another article. Patient- and tumor-related prognostic factors, their association with survival indices, and their roles in different scores and predictive tools are discussed. Patient-related factors include age, sex, ethnicity, tobacco consumption, surgical delay, sarcopenia, nutritional status, and several blood-based markers. Tumor-related prognosticators comprise stage, grade, presentation, location, multifocality, size, lymphovascular invasion, surgical margins, lymph node status, mutational landscape, architecture, histologic variants, and tumor-stroma ratio. The accuracy and validation of pre-operative predictive tools, which incorporate various prognosticators to predict the risk of muscle-invasive or non-organ confined disease, and help to decide on the surgery type (radical nephroureterectomy, or kidney-sparing procedures) are also investigated. Post-operative nomograms, which help decide on adjuvant chemotherapy and plan follow-up are explored. Finally, a revision of the current stratification of UTUC patients is endorsed.

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Risk Stratification of Upper Tract Urothelial Carcinoma for Kidney-Sparing Surgery

2021

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Kidney-sparing Management Versus Nephroureterectomy for Upper Tract Urothelial Carcinoma: a Systematic Review and Meta-analysis

Cited by 10 publications

References 45 publications

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma

Upper Tract Urothelial Carcinoma (UTUC) Diagnosis and Risk Stratification: A Comprehensive Review

Risk Stratification of Upper Tract Urothelial Carcinoma for Kidney-Sparing Surgery

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