Kidney stone proteomics: an update and perspectives

Peerapen, Paleerath; Thongboonkerd, Visith

doi:10.1080/14789450.2021.1962301

Cited by 20 publications

(15 citation statements)

References 114 publications

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“…More than a thousand of proteins have been identified from urine of the stone formers [ 6 ] and kidney stone matrices [ 7 ]. Additionally, alterations of protein expression in renal tubular epithelial cells (RTECs) by COM crystals have been identified via proteomics approach [ 8 – 17 ]. Interestingly, functional analyses have demonstrated that some of such altered proteins play roles as modulators (promoters or inhibitors) [ 18 , 19 ] and COM crystal receptors [ 20 – 22 ] during the stone-forming processes.…”

Section: Introductionmentioning

confidence: 99%

Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes

Yoodee

Peerapen

Plumworasawat

et al. 2022

Cell. Mol. Life Sci.

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Human heat-shock protein 90 (HSP90) has four functional domains, including NH 2 -terminal (N), charged linker region (LR), middle (M) and COOH-terminal (C) domains. In kidney stone disease (or nephrolithiasis/urolithiasis), HSP90 serves as a receptor for calcium oxalate monohydrate (COM), which is the most common crystal to form kidney stones. Nevertheless, roles of HSP90 and its four domains in kidney stone formation remained unclear and under-investigated. We thus examined and compared their effects on COM crystals during physical (crystallization, growth and aggregation) and biological (crystal–cell adhesion and crystal invasion through extracellular matrix (ECM)) pathogenic processes of kidney stone formation. The analyses revealed that full-length (FL) HSP90 obviously increased COM crystal size and abundance during crystallization and markedly promoted crystal growth, aggregation, adhesion onto renal cells and ECM invasion. Comparing among four individual domains, N and C domains exhibited the strongest promoting effects, whereas LR domain had the weakest promoting effects on COM crystals. In summary, our findings indicate that FL-HSP90 and its four domains (N, LR, M and C) promote COM crystallization, crystal growth, aggregation, adhesion onto renal cells and invasion through the ECM, all of which are the important physical and biological pathogenic processes of kidney stone formation. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s00018-022-04483-z.

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Section: Introductionmentioning

confidence: 99%

Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes

Yoodee

Peerapen

Plumworasawat

et al. 2022

Cell. Mol. Life Sci.

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“…They often wait until the accumulation of kidney stones is too large, and the patients feel obviously uncomfortable [ 3 , 4 ]. The main incidence group of kidney stone is young and middle-aged male [ 5 ]. However, the incidence of kidney stone in male group is much higher than that in female group [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

Ai¹,

Dong²,

Li³

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. A case-control study was conducted to determine the effectiveness of laparoscopic surgery and traditional open surgery on stone clearance, laboratory indexes, and life quality in patients with renal calculi. Methods. During March 2017 to March 2022, 272 patients with complex renal calculi (CRC) cured in our hospital were assigned into control group ( n = 136 ) and research group ( n = 136 ) arbitrarily. The former accepted traditional open surgery, while the latter accepted laparoscopic surgery. The operation time, intraoperative blood loss, hospital stay, and time of getting out of bed were compared. The degree of postoperative incision pain was assessed by visual analogue scale (VAS). The life quality was assessed by the Comprehensive Assessment Questionnaire-74 (GQOL-74). The indexes of renal function and urine metabolism were measured. Then, the postoperative stone clearance rate and complications were calculated. Results. Operation time, blood loss intraoperatively, time out of bed, and hospitalization were all remarkably reduced in the research group, and the difference was statistically significant ( P < 0.05 ). The complete stone clearance rates in study and control cohorts were 75.73% and 63.24%, respectively. The VAS scores were lessened after the operation. Compared with the two groups, the VAS scores of the research group were remarkably lower at 1 to 2 weeks and 1 and 3 months after the operation, and the difference was statistically significant ( P < 0.05 ). One week after operation, the levels of β 2-microglobulin (β 2-MG), N-acetyl-β-glucosaminidase (NAG), and renal injury molecule-1 (kidney injury molecule-1, Kim-1) in the research group were remarkably lower. The levels of urinary β 2-MG, NAG, and KIM-1 in the research group were remarkably lower, and the difference was statistically significant ( P < 0.05 ). One week after operation, the levels of urinary oxalic acid, uric acid, and urinary calcium lessened averagely. The levels of urinary oxalic acid, uric acid, and urinary calcium in the research group were lower, and the difference was statistically significant ( P < 0.05 ). The quality-of-life scores were compared. One week after the operation, the scores of physical function, psychological function, social function, and material function were all augmented, and the difference was statistically significant ( P < 0.05 ). The incidence of complications was 9.56% and 2.21%, respectively. The incidence of complications in the research group was lower, and the difference was statistically significant ( P < 0.05 ). Conclusion. Laparoscopic surgery is successful when treating CRC, which is superior to invasive surgery in postoperative complications, stone clearance rate, improvement of postoperative renal function, and life quality. It is one of the ideal treatment methods for CRC. However, the role of open surgery when treating CRC cannot be ignored. This needs to be further confirmed by large samples of randomized controlled trials.

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“…Remarkably, both EVs and mitochondria are acknowledged to be the crucial players in kidney stone formation [ 25 , 130 , 131 , 148 , 159 – 161 ]. As such, using anti-oxidants and/or other means of preservation of mitochondrial functions are expected to be one of the ideal strategies for KSD prevention [ 129 , 162 – 166 ].…”

Section: Potential Roles Of Mdvs In Ksdmentioning

confidence: 99%

Mitochondria-derived vesicles and their potential roles in kidney stone disease

Chaiyarit

Thongboonkerd

2023

J Transl Med

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Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.

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Kidney stone proteomics: an update and perspectives

Cited by 20 publications

References 114 publications

Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes

Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

Mitochondria-derived vesicles and their potential roles in kidney stone disease

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