Kidney transplant outcomes among recipients with post‐transplant hip or knee joint replacement surgery

Abstract

Introduction:Patients with end-stage renal disease (ESRD) are at a higher risk of needing hip or knee replacement (joint replacement) surgery due to the high prevalence of degenerative joint disease and other conditions. However, there remains a large debate about the timing of joint replacement surgery and whether it should be pre-vs posttransplant. Methods:We conducted a retrospective study analyzing all adult kidney transplant recipients (KTRs) at our university hospital who had undergone subsequent joint replacement between 2001 and 2017. Transplant-specific outcomes of acute rejection, death censored graft failure (DCGF), and patient death post-joint replacement surgery were outcomes of interest. Controls were selected at a 1:3 ratio based on the incidence density sampling of post-transplant interval.Results: There were 101 KTRs in the joint replacement group and were compared with 281 controls. In the multivariate analysis, the need for joint replacement was not asso-

Avascular Necrosis in Kidney Transplant Recipients is Associated With an Increased Risk of Patient Death

“…Recently, in one report among 101 kidney transplant recipients, 23% had joint replacement surgery attributed to avascular necrosis. 8 Similar to the previous studies, the overall incidence of avascular necrosis has decreased in the modern era and in this cohort, <2% had this debilitating condition. 1 Although not statistically significant, similar to the previous reports, calcineurin inhibitor-based immunosuppressive agents were protective against avascular necrosis.…”

“…Recently, in one report among 101 kidney transplant recipients, 23% had joint replacement surgery attributed to avascular necrosis. 8…”