Kidney Transplant Recipients Show an Increase in the Ratio of T-Cell Effector Memory/Central Memory as Compared to Nontransplant Recipients on the Waiting List

Segundo, David San; Fernández‐Fresnedo, Gema; Gago, M.; Beares, Iñaki; Ruiz-Criado, Jorge; González, M.; Ruiz, Julio C.; Gómez-Alamillo, C.; López-Hoyos, Marcos; Arias, Manuel

doi:10.1016/j.transproceed.2010.07.072

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…22 This is indirectly in agreement with previous data from our group showing decreased number of T CM CD3 + cells in patients with long-term failed grafts and reintroduced in the waiting list. 23 In the present study, we observed that even several months after diagnosis, those patients suffering with an AR episode maintained increased percentages of CD4 + T EM and CD8 + T EM cells (Figure 3), although it did not affect graft survival. This is in contrast with the apparent decrease of both T EM subsets in the short-term follow-up of those patients suffering AR (Figure 1a and b).…”

Section: Resultssupporting

confidence: 48%

Changes in the number of circulating TCM and TEM subsets in renal transplantation: relationship with acute rejection and induction therapy

Segundo

Fernández‐Fresnedo

Gago

et al. 2011

Kidney International Supplements

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Effector (TEM) and central memory (TCM) T cells have been recently described as the main memory T-cell subsets generated after primary immune response, with a potential role in graft rejection after rechallenge with alloantigen. Because of their effector function, they could be involved in driving the response against the allograft, leading to rejection. In this study, we sought to investigate the different memory T-cell subpopulations in peripheral blood from a cohort of 90 patients who underwent consecutive renal transplant, and their association with acute rejection (AR) episodes and induction therapy. Twenty-one of them were monitored in the short term during the first 2 months after transplantation. Three of them suffered an AR but no changes in the circulating levels of either CD4+ or CD8+ TEM were observed as compared with rejection-free renal transplant patients. In total, 69 patients out of 90 were monitored in the long term. Even 2 years after transplantation, maintained increased numbers of peripheral blood CD4+ TEM were observed in patients suffering with AR. Interestingly, induction therapy with thymoglobulin, but not with basiliximab, produced an increase in circulating CD4+ TEM cells at 6 months after transplantation. In conclusion, our data suggest that AR episodes favor the induction of TEM cells in the periphery of renal transplant patients in the long term. It remains to be determined whether such an effect has any impact on long-term renal transplantation.

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Section: Resultssupporting

confidence: 48%

Changes in the number of circulating TCM and TEM subsets in renal transplantation: relationship with acute rejection and induction therapy

Segundo

Fernández‐Fresnedo

Gago

et al. 2011

Kidney International Supplements

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“…However, in our study, both CD4+ and CD8+ EM T cells showed a lower frequency in the ESRD group. Although this finding was not consistent with Chung’s observation, the ratio of EM/CM T cells was decreased in the ESRD group, which was identical to the conclusion of Segundo’s study (Segundo et al, 2010). Taken together, an impact of previous renal disease and dialysis indeed existed in some T cell subsets.…”

Section: Discussioncontrasting

confidence: 72%

The detailed distribution of T cell subpopulations in immune-stable renal allograft recipients: a single center study

Zhuang

Peng

Wei

et al. 2019

PeerJ

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BackgroundMost renal allograft recipients reach a stable immune state (neither rejection nor infection) after transplantation. However, the detailed distribution of overall T lymphocyte subsets in the peripheral blood of these immune-stable renal transplant recipients remains unclear. We aim to identify differences between this stable immune state and a healthy immune state.MethodsIn total, 103 recipients underwent renal transplantation from 2012 to 2016 and received regular follow-up in our clinic. A total of 88 of these 103 recipients were enrolled in our study according to the inclusion and exclusion criteria. A total of 47 patients were 1 year post-transplantation, and 41 were 5 years post-transplantation. In addition, 41 healthy volunteers were recruited from our physical examination clinic. Detailed T cell subpopulations from the peripheral blood were assessed via flow cytometry. The parental frequency of each subset was calculated and compared among the diverse groups.ResultsThe demographics and baseline characteristics of every group were analyzed. The frequency of total T cells (CD3+) was decreased in the renal allograft recipients. No difference in the variation of the CD4+, CD8+, and activated (HLA-DR+) T cell subsets was noted among the diverse groups. Regarding T cell receptor (TCR) markers, significant reductions were found in the proportion of γδ T cells and their Vδ2 subset in the renal allograft recipients. The proportions of both CD4+ and CD8+ programmed cell death protein (PD) 1+ T cell subsets were increased in the renal allograft recipients. The CD27+CD28+ T cell proportions in both the CD4+ and CD8+ populations were significantly decreased in the allograft recipients, but the opposite results were found for both CD4+ and CD8+ CD27-CD28- T cells. An increased percentage of CD4+ effector memory T cells and a declined fraction of CD8+ central memory T cells were found in the renal allograft recipients.ConclusionLimited differences in general T cell subsets (CD4+, CD8+, and HLA-DR+) were noted. However, obvious differences between renal allograft recipients and healthy volunteers were identified with TCR, PD1, costimulatory molecules, and memory T cell markers.

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“…T regs are a very heterogeneous population of cells and many methodological problems arise in the course of their study. Different gating strategies used for quantification of T regs (CD4 + CD25 + [38], CD4 + CD25 high [30], CD4 + CD25 high CD127 low [22], CD4 + CD25 high FoxP3 + [39], CD4 + CD25 high CD127 low FoxP3 + [40] or the gating we chose, based on the intercept of three different gates on CD4 subpopulation (as indicated in Fig. 1), can give quite different results leading to controversial conclusions.…”

Section: Discussionmentioning

confidence: 99%

Impaired function of regulatory T cells in cord blood of children of allergic mothers

Hrdý

Kocourková

Prokešová

2012

Clinical and Experimental Immunology

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SummaryAllergy is one of the most common diseases with constantly increasing incidence. The identification of prognostic markers pointing to increased risk of allergy development is of importance. Cord blood represents a suitable source of cells for searching for such prognostic markers. In our previous work, we described the increased reactivity of cord blood cells of newborns of allergic mothers in comparison to newborns of healthy mothers, which raised the question of whether or not this was due to the impaired function of regulatory T cells (

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Kidney Transplant Recipients Show an Increase in the Ratio of T-Cell Effector Memory/Central Memory as Compared to Nontransplant Recipients on the Waiting List

Cited by 7 publications

References 7 publications

Changes in the number of circulating TCM and TEM subsets in renal transplantation: relationship with acute rejection and induction therapy

Changes in the number of circulating TCM and TEM subsets in renal transplantation: relationship with acute rejection and induction therapy

The detailed distribution of T cell subpopulations in immune-stable renal allograft recipients: a single center study

Impaired function of regulatory T cells in cord blood of children of allergic mothers

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