Kidney transplantation from uncontrolled donation after circulatory death (IIa): Organ procurement and renal harvested over a ten year period

Polo, J. Medina; Justo-Quintas, J.; Gil-Moradillo, J.; Rosa-Kehrmann, Federico de la; Pamplona-Casamayor, M.; Rodrı́guez-Antolı́n, A.; Duarte-Ojeda, J.M.; Tejido-Sánchez, Á.; Villacampa-Aubá, F.; Sopeña-Sutil, R.; Benítez-Sala, R.; Guerrero-Ramos, F.; Andrés-Belmonte, Amado; Passas-Martínez, J.B.

doi:10.1016/s1569-9056(17)31063-1

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“…Although there are logistical and ethical concerns around using kidneys from uDCD donors, 5,6 there is growing evidence demonstrating that uDCD kidney grafts have comparable short-term allograft survival to controlled DCD (cDCD). 5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20] However, the long-term outcomes from uDCD kidney transplantation are not clearly defined. Therefore, the aim of this review was to summarize the available evidence on the short-and long-term outcomes from uDCD kidney transplantation and to compare these to cDCD and donation after brain death (DBD) outcomes.…”

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confidence: 99%

Kidney Transplantation Outcomes From Uncontrolled Donation After Circulatory Death: A Systematic Review and Meta-analysis

Vijayan,

Schroder,

Hameed

et al. 2024

Transplantation

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Background. Uncontrolled donation after circulatory death (uDCD) is a potential additional source of donor kidneys. This study reviewed uDCD kidney transplant outcomes to determine if these are comparable to controlled donation after circulatory death (cDCD). Methods. MEDLINE, Cochrane, and Embase databases were searched. Data on demographic information and transplant outcomes were extracted from included studies. Meta-analyses were performed, and risk ratios (RR) were estimated to compare transplant outcomes from uDCD to cDCD. Results. Nine cohort studies were included, from 2178 uDCD kidney transplants. There was a moderate degree of bias, as 4 studies did not account for potential confounding factors. The median incidence of primary nonfunction in uDCD was 12.3% versus 5.7% for cDCD (RR, 1.85; 95% confidence intervals, 1.06-3.23; P = 0.03, I2 = 75). The median rate of delayed graft function was 65.1% for uDCD and 52.0% for cDCD. The median 1-y graft survival for uDCD was 82.7% compared with 87.5% for cDCD (RR, 1.43; 95% confidence intervals, 1.02-2.01; P = 0.04; I2 = 71%). The median 5-y graft survival for uDCD and cDCD was 70% each. Notably, the use of normothermic regional perfusion improved primary nonfunction rates in uDCD grafts. Conclusions. Although uDCD outcomes may be inferior in the short-term, the long-term outcomes are comparable to cDCD.

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