Kidney Transplantation in Children With Augmentation Cystoplasty

Basiri, Abbas; Otoukesh, Hassan; Simforoosh, Nasser; Hosseini, Rozita; Farrokhi, Farhat

doi:10.1016/j.juro.2007.03.049

Cited by 28 publications

(32 citation statements)

References 16 publications

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“…These patients often need some form of urinary diversion (conduit or reservoir), which is associated with a higher risk for chronic and potentially invasive infections, an increased risk for malignancies, and a less favorable outcome after renal transplantation (25,26). In addition, these patients may have various neurologic comorbid conditions and complications that could affect their long-term survival.…”

Section: Discussionmentioning

confidence: 99%

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Timing and Outcome of Renal Replacement Therapy in Patients with Congenital Malformations of the Kidney and Urinary Tract

Wühl¹,

Stralen²,

Verrina³

et al. 2013

Clinical Journal of the American Society of Nephrology

198

108

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SummaryBackground and objectives Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of ESRD in children, but the proportion of patients with individual CAKUT entities progressing to ESRD during adulthood and their long-term clinical outcomes are unknown. This study assessed the age at onset of renal replacement therapy (RRT) and patient and renal graft survival in patients with CAKUT across the entire age range.Design, setting, participants, & measurements Patients with CAKUT were compared with age-matched patients who were undergoing RRT for other renal disorders on the basis of data from the European Renal AssociationEuropean Dialysis and Transplant Association Registry. Competing risk and Cox regression analyses were conducted.Results Of 212,930 patients commencing RRT from 1990 to 2009, 4765 (2.2%) had renal diagnoses consistent with CAKUT. The proportion of incident RRT patients with CAKUT decreased from infancy to childhood and then increased until age 15-19 years, followed by a gradual decline throughout adulthood. Median age at RRT start was 31 years in the CAKUT cohort and 61 years in the non-CAKUT cohort (P,0.001). RRT was started earlier (median, 16 years) in patients with isolated renal dysplasia than in those with renal hypoplasia and associated urinary tract disorders (median, 29.5-39.5 years). Patients with CAKUT survived longer than age-and sex-matched non-CAKUT controls because of lower cardiovascular mortality (10-year survival rate, 76.4% versus 70.7%; P,0.001).Conclusions CAKUT leads to ESRD more often at adult than pediatric age. Treatment outcomes differ from those of acquired kidney diseases and vary within CAKUT subcategories.

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Section: Discussionmentioning

confidence: 99%

“…Patients with "pyelonephritis cause not specified" (code 20), "pyelonephritis due to acquired obstructive uropathy" (code 23), "pyelonephritis due to urolithiasis" (code 25), and "pyelonephritis due to other cause" (code 29) were not included in the analysis.…”

Section: Introductionmentioning

confidence: 99%

Timing and Outcome of Renal Replacement Therapy in Patients with Congenital Malformations of the Kidney and Urinary Tract

Wühl¹,

Stralen²,

Verrina³

et al. 2013

Clinical Journal of the American Society of Nephrology

198

108

View full text Add to dashboard Cite

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“…Especially, the immunosuppressive agents administered during transplantation have a particular impact on the patient immunity [6,7]. Therefore, we focused on the management of UTI before and after transplantation.…”

Section: Discussionmentioning

confidence: 99%

A Study of Renal Transplant for Patients with Neurogenic Bladder

Matsuda¹,

Kobayashi²,

Nanmoku³

et al. 2014

UCMS

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Abstract:In our hospital, we performed renal transplants on 12 patients with neurogenic bladder between 1992 and 2010. Three patients with bladder dysfunction had undergone pre-operative cystoplasties for the improvement of their bladder compliance. Patients were divided into high-risk and low-risk groups according to risk of urinary tract complications and infections after renal transplants. The levels of risk were determined on the basis the patients' pre-operative bladder functions and urination states, and the two groups were compared with respect to the incidence of post-operative UTIs (urinary tract infections) and level of renal function. All patients, except a female who could not perform regular CIC (clean intermittent catheterizations) to maintain adequate urine output, were able to maintain renal function. A recipient was able to deliver a baby safely. In addition, we were able to treat post-operative UTIs by increasing the frequency of CICs and by adding a night balloon.

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“…Bladder augmentation before renal transplantation has the benefit of preventing the neuropathic bladder-induced renal transplant damage. 37,38 Concerns have been raised that bladder augmentation may increase the technical difficulty of subsequent renal transplantation, reduce the success of peritoneal dialysis before transplantation, increase the risk of UTI, and hasten the progression to ESRD. However, recent studies have reported equivalent infection rates and no evidence of an accelerated progression to ESRD.…”

Section: Renal Transplantationmentioning

confidence: 99%