Kidney Transplantation in COVID Pandemic—A Review of Guidelines

Gut, Gabriela; Góral, Agata; Canton, Zofia Dal; Poznański, Paweł; Krajewska, Magdalena; Kusztal, Mariusz

doi:10.3390/jcm10132877

Cited by 7 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many indications that the adoption of the vaccine will change a lot in the peritransplant procedure and allow transplantation programs to be reopened. A few basic rules and timing of vaccination against COVID-19 in transplant recipients and candidates were proposed [ 132 ]. Due to quicker lowering of post-vaccination antibodies post-transplantation, it is anticipated that, in the case of the COVID-19 vaccine, an additional shot (or schedule) will be required.…”

Section: Vaccinationmentioning

confidence: 99%

See 1 more Smart Citation

The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients

Dęborska−Materkowska

Kamińska

2021

Viruses

View full text Add to dashboard Cite

Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an enormous rise in scientific response with an excess of COVID-19-related studies on the pathogenesis and potential therapeutic approaches. Solid organ transplant (SOT) recipients are a heterogeneous population with long-lasting immunosuppression as a joining element. Immunocompromised patients are a vulnerable population with a high risk of severe infections and an increased infection-related mortality rate. It was postulated that the hyperinflammatory state due to cytokine release syndrome during severe COVID-19 could be alleviated by immunosuppressive therapy in SOT patients. On the other hand, it was previously established that T cell-mediated immunity, which is significantly weakened in SOT recipients, is the main component of antiviral immune responses. In this paper, we present the current state of science on COVID-19 immunology in relation to solid organ transplantation with prospective therapeutic and vaccination strategies in this population.

show abstract

Section: Vaccinationmentioning

confidence: 99%

“…Based on accumulating evidence, the adjustment of immunosuppression was less common during the second COVID-19 wave in Spain [131]. Various transplant society recommendations usually suggest stopping antiproliferative agents or continuing the use of standard immunosuppression [132].…”

Section: Adjustment Of Immunosuppressionmentioning

confidence: 99%

The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients

Dęborska−Materkowska

Kamińska

2021

Viruses

View full text Add to dashboard Cite

show abstract

“…No patient from the ASTREGO cohort received immunotherapies or convalescent plasma, but this was administered to 2%–6% of patients in other regions. These observations show that there is no consistent approach to the management of COVID-19 in solid organ transplant recipients, but some countries have developed national COVID-19 management protocols to standardize treatments [ 24 ]. As a result, this diversity in therapeutic approaches hampers the interpretation of treatment and outcome data.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report

Kee

Jeong

Rashid

et al. 2021

Korean J Transplant

View full text Add to dashboard Cite

Background: Asia is the global epicenter of the coronavirus disease 2019 (COVID-19) pandemic; however, COVID-19-related mortality in Asia remains lower than in other parts of the world. It is uncertain whether the mortality of COVID-19-infected kidney transplant recipients (KTXs) from Asia follows the lower mortality trends of the younger Asian population. Methods: Specific transplant centers from countries in the Asian Society of Transplantation were invited to participate in a study to examine the epidemiology, clinical features, natural history, and outcomes of COVID-19 infections in KTXs. Data were analyzed and compared with those of large cohort studies from other countries. Results: The study population was 87 KTXs from nine hospitals in seven Asian countries. Within the study population, 9% were aged 60 years and older, and 79% had at least one comorbidity. The majority of patients (69%) presented with mild-to-moderate COVID-19 severity. Disease progression was more frequently encountered among those with moderate or severe infection (23%) and non-survivors (55%). The mortality rate was 23% (n=20) and differed according to the level of care: 12% (n=1/8), 15% (n=10/67), and 100% (n=9/9) of patients managed as outpatients, in the general ward, and in the intensive care unit, respectively. Disease severity at the time of presentation was an independent predictor of mortality. Compared with the mortality rates in other studies worldwide, mortality rates in the current study were comparable. Conclusions: Mortality in Asian KTXs who were infected with COVID-19 remains high and could be related to comorbidity burden and the constraints of the general healthcare system when the COVID-19 caseload is high.

show abstract

“…Staff in the blood collection agencies have SARS-CoV-2 nucleic acid tests (NAT) regularly, and isolation should be taken immediately once fever and other SARS-CoV-2-related symptoms appeared. In addition, donation by appointment helps to reasonably control the number of blood donors to avoid being overcrowding [39].…”

Section: Preventive Measures Adopted To Ensure Blood Safety During Th...mentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Blood Safety

He¹,

Shi

Li³

et al. 2022

Acta Haematol

View full text Add to dashboard Cite

Since the outbreak of SARS-CoV-2, it has spread rapidly around the world and caused a serious global social crisis. During the epidemic, the blood collection and supply industry have been greatly impacted, due to the sharply dropped blood donors and transfusion transmission risk of SARS-CoV-2. Many infected individuals are asymptomatic and they may donate blood without awareness of the infection or before symptoms appear. In addition, viral RNAs have been detected in the blood of some patients infected with SARS-CoV-2. Although no infectious SARS-CoV-2 virus was found in the blood nor the blood components, there is a risk of transmission through blood transfusion which may endanger blood safety, especially during the pandemic period. This review briefly introduces the biological characteristics, epidemiology of SARS-CoV-2, with a particular focus on SARS-CoV-2 infection and blood safety.

show abstract

Kidney Transplantation in COVID Pandemic—A Review of Guidelines

Cited by 7 publications

References 12 publications

The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients

The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients

Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report

Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Blood Safety

Contact Info

Product

Resources

About