Kidney transplantation

Barlow, Adam D.; Ghoneima, Ahmed S.

doi:10.1016/j.mpsur.2020.04.009

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Particularly at risk of this complication are immunised recipients who, to a greater extent than non-immunised recipients, are exposed to the risk of rejection associated with the activation of humoral immunological factors, i.e. specific anti-HLA antibodies and complement activation [5,6,13,14]. Therefore, significant factors associated with graft rejection include HLA antigen mismatch in the donor-recipient system, and prior sensitisation of potential recipients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the level of alloantibodies and selected cytokines in kidney recipients

Wojciechowska‐Koszko¹,

Nowosiad-Magda²,

Krasnodębska-Szponder³

et al. 2022

J Pre Clin Clin Res.

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Introduction and Objective. Anti-HLA antibodies, especially anti-DSA, are believed to be potentially involved in acute and chronic rejection. New techniques, e.g. flow fluorimetry, can be an excellent supplement to the lymphocytotoxic tests currently used in pre-transplantation practice, and become a tool for monitoring post-transplant immunisation. The aim of the study was to assess the level of cytokines and alloimmunisation in kidney recipients, with the histopathological evaluation of the transplanted kidney biopsy. Materials and method. The study included 62 graft recipients six months after transplant. The level of anti-HLA antibodies was assessed using the x-Map Luminex technique, and the level of cytokines (IFN-γ, IL-4, IL-10, IL-17) was determined using the ELISA test. Results. Histopathological analysis showed that more than 45.2% of patients had changes in the biopsy material. Analysis of the level of alloimmunisation showed that in over 75.8%, the presence was detected of anti-HLA IgM class I antibodies, while anti-HLA IgM class II antibodies were found less often -17.8%. The level of anti-HLA IgG antibodies, depending on the type of the assessed class, respectively, was: class I -43.5% and class II -50%. More than half of the subjects also had anti-MICA antibodies. The level of analysed cytokines was low. Conclusions. The results indicate significant alloimmunisation of kidney recipients, although they do not answer the question whether these are antibodies that appeared de novo after transplantation, and whether anti-DSA antibodies were present among them. For this purpose, the diagnostics should be expanded to include anti-HLA monitoring in the pre-and post-transplant period, using screening tests and tests to identify their specificity. The protocol biopsy and examination of level cytokine can also be a helpful tool in post-transplant diagnosis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the level of alloantibodies and selected cytokines in kidney recipients

Wojciechowska‐Koszko¹,

Nowosiad-Magda²,

Krasnodębska-Szponder³

et al. 2022

J Pre Clin Clin Res.

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“…Por este motivo, os doadores são também avaliados psicologicamente quanto às motivações do ato de doação, a fim de excluir coerção externa ou emocional. Além disso os programas de doação intervivos são realizados com extremo cuidado, priorizando a saúde e bem-estar dos doadores em relação ao benefício esperado para o receptor, não sendo portanto, aceitáveis índices de complicação ou riscos elevados para o doador65,66 . a) A conformação de trajeto mais frequente do tronco celíaco em sagital, consiste em angulação caudal após sua origem, seguida de desvio cranial antes de sua primeira ramificação.…”

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Avaliação quantitativa da compressão do tronco celíaco pelo ligamento arqueado mediano e da anatomia normal da origem do tronco celíaco em angiotomografias de pacientes assintomáticos

Petnys¹

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Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation

Cooper

Hurst

2022

Xenotransplantation

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Mathieu Jaboulay was a professor of clinical surgery in Lyon, France who is best known for his development of vascular anastomosis and for conducting the first reported renal xenotransplantation experiments on humans, using pig and goat kidneys to treat end-stage renal failure in 1906. His insights and pioneering techniques contributed significantly to allotransplantation and contemporary attempts at xenotransplantation. He is also credited with inventing several surgical instruments and novel surgical techniques that continue to influence vascular, general, and urological surgery to this day. However, this article will focus specifically on his notable contributions to xenotransplantation research and surgery.

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Kidney transplantation

Cited by 3 publications

References 5 publications

Evaluation of the level of alloantibodies and selected cytokines in kidney recipients

Evaluation of the level of alloantibodies and selected cytokines in kidney recipients

Avaliação quantitativa da compressão do tronco celíaco pelo ligamento arqueado mediano e da anatomia normal da origem do tronco celíaco em angiotomografias de pacientes assintomáticos

Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation

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