Kidney Transplants in Controlled Donation Following Circulatory Death, or Maastricht Type III Donors, With Abdominal Normothermic Regional Perfusion, Optimizing Functional Outcomes

Ramírez, Patricia; Vázquez, Diego García-Germán; Rodriguez, Gabriel A.; Rubio, Juan José Álvarez; Pérez, M.; Pórtoles, José; Carballido, Joaquı́n

doi:10.1097/txd.0000000000001174

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…However, these studies did not compare the use of NRP with the widespread SRR. Ramirez et al found that DCD kidneys treated with NRP had a lower rate of DGF than those with SRR 27 . In a recent Spanish nationwide propensity score analysis, Padilla et al have found that NRP was associated with improved rates of DGF and 1-year graft loss compared to SRR 28 .…”

Section: Results Of Kts With Nrpmentioning

confidence: 99%

Abdominal Normothermic Regional Perfusion in Donation After Circulatory Death: Organ Viability or Organ Preservation?

Carlis

Centonze

Migliorini

et al. 2023

EJT

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Transplants from donation after circulatory death (DCD) provide a viable means to deal with the ever-growing shortage of donors but are burdened by a higher rate of complications and graft loss. Dismal results have prompted the application of stricter donor and graft selection criteria and the use of machine perfusion technologies, such as normothermic regional perfusion (NRP). In this review, we first describe the diffusion of NRP worldwide. Next, the role of NRP in liver transplantation is discussed, with a particular focus on graft selection during perfusion and posttransplant outcomes. Finally, we review the clinical studies reporting on NRP in kidney transplantation. The emerging use of NRP with complementary ex-situ machine perfusion is also described. NRP improves organ quality and maintenance before cold preservation, turns the DCD procedure into a more unhurried one, and allows the assessment of organ function following the warm ischemic injury. Moreover, it is beneficial for both the liver and the kidneys from the same donor.

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Section: Results Of Kts With Nrpmentioning

confidence: 99%