Kidney tubular-cell secretion of osteoblast growth factor is increased by kaempferol: A scientific basis for “The Kidney Controlling the Bone” theory of chinese medicine

Long, Mian; Li, Shunxiang; Xiao, Jiang-feng; Wang, Jian; Lozanoff, Scott; Zhang, Zhiguang; Luft, Benjamin J.; Johnson, Francis

doi:10.1007/s11655-014-1336-z

Cited by 1 publication

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“…The authors found that kaempferol increased cell growth, secretion of osteoblast growth factor and level of BMPR II in opossum kidney cells. Findings from this study implied that kaempferol stimulated kidney repair which indirectly stimulates bone formation 57…”

Section: In Vitro Studies and Mechanism Of Action Of Kaempferol As A mentioning

confidence: 59%

“…Treatment with noggin (a BMP-2 antagonist) blocked BMP-2-induced ALP activity, phosphorylation of SMAD1/5/8 and p38, thus suggesting that BMP-2 signaling was implicated in the osteogenic action of 8-prenylkaempferol 56. Apart from the protecting action of BMP-2 produced in osteoblasts, bone morphogenetic protein receptor II (BMPR II) was identified in opossum kidney cells 57. The authors found that kaempferol increased cell growth, secretion of osteoblast growth factor and level of BMPR II in opossum kidney cells.…”

Section: In Vitro Studies and Mechanism Of Action Of Kaempferol As A mentioning

confidence: 99%

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<p>The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies</p>

Wong

Chin

2019

DDDT

126

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Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementation showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.

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Section: In Vitro Studies and Mechanism Of Action Of Kaempferol As A mentioning

confidence: 59%

Section: In Vitro Studies and Mechanism Of Action Of Kaempferol As A mentioning

confidence: 99%

<p>The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies</p>

Wong

Chin

2019

DDDT

126

View full text Add to dashboard Cite

show abstract

Kidney tubular-cell secretion of osteoblast growth factor is increased by kaempferol: A scientific basis for “The Kidney Controlling the Bone” theory of chinese medicine

Abstract: This lends strong support to the original idea that the Kidney has a significant influence over bone-formation, as suggested by some long-standing Chinese medical beliefs, kaempferol may also serve to stimulate kidney repair and indirectly stimulate bone formation.

Cited by 1 publication

References 19 publications

<p>The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies</p>

<p>The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies</p>

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