Kidney Tubules — Scientific and Applied Value

Levitskaya, E. S.; Batiushin, M. M.

doi:10.20514/2226-6704-2022-12-6-405-421

Cited by 3 publications

(1 citation statement)

References 89 publications

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“…Эти два метаболита являются конечными продук-тами метаболизма белка и выводятся из крови в клубочках почек, однако в проксимальных канальцах мочевина подвергается реабсорбции, а всасывание креатинина минимальное. Поэтому, при нарушении клубочковой фильтрации нарушается соотношение азота мочевины и креатинина [10,11]. В нашем опыте у рыб из лотка №1 отмеченное соотношение увеличилось с 52,2 до 60,5, а в №2 с 50,8 до 52,6.…”

Section: введение / Introductionunclassified

Production tests of a sorption feed additive for rainbow trout

Popova,

Alеkhin

2024

jour

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Against the backdrop of intensification of aquaculture technologies, the severity of deterrent factors is increasing; among the most relevant in this issue, the quality of feed should be noted, the low level of which creates the risks of feed poisoning, metabolic disorders and the initiation of disease development. In the conditions of fish farms, research was carried out to study the safety and effectiveness of using a sorptionmetabolic feed additive for fish, developed by employees of the Federal State Budgetary Educational Institution of Higher Education of St. Petersburg State University of Internal Affairs and EcoGroup LLC (Russia). The object of the study was rainbow trout, which during the growing period for 60 days received feed with the specified additive. Statistical processing of the results obtained using the Statistica 8.0 program included the calculation of the arithmetic mean and its standard error (M±m), and the intergroup difference (p) was assessed using the student’s t test. The results of the study showed that the developed feed additive does not have a negative effect on the fish body, and its use eliminates the occurrence of metabolic disorders and the development of liver and kidney pathologies, the risk of which increases with the intensification of aquaculture technology. Against the backdrop of giving a new feed additive, not only does the weight and body size of the fish increase, but its growth potential during periods of further cultivation increases. Thus, the developed sorption-metabolic feed additive is harmless to fish, has a positive effect on their growth and development, and reduces the risks of metabolic disorders and the development of pathologies. All this provides grounds for the use of this feed additive in aquaculture.

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Section: введение / Introductionunclassified

Production tests of a sorption feed additive for rainbow trout

Popova,

Alеkhin

2024

jour

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Cardiorenal continuum: clinical and pathogenetic relationships between heart failure with preserved ejection fraction and renal tubular dysfunction

Levitskaya,

Batyushin,

Zakusilov

et al. 2024

Cardiovasc Ther Prev

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The article presents data on the high relevance of studying a renal tubular injury in heart failure with preserved ejection fraction (HFpEF). The available research data and prerequisites for HFpEF development and renal tubular injury in detail. Markers of tubulopathy are presented. The main paradigm of cardiorenal syndrome in HFpEF with renal tubular injury is discussed — the unity of risk factors and pathogenetic mechanisms (low-intensity chronic inflammation, endothelial dysfunction, profibrotic hyperactivity). The need to identify markers of tubular dysfunction is due to expanding preventive capabilities to slow down the cardiorenal continuum stages — a decrease in filtration function and further remodeling of the myocardium and vascular bed. The review presents the analysis of available Russian and foreign data and analytical portals.

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Role of beta 2 microglobulin in chronic kidney disease

Murkamilov,

Aitbaev,

Murkamilova

et al. 2023

Nefrologiâ (St.-Peterbg.)

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The aim: to study the relationship of beta-2-microglobulin (beta-2 MG) with clinical and laboratory manifestations of chronic kidney disease (CKD).Patients and Methods. The results of a comprehensive examination of 284 people (118 males and 166 females) aged 18 to 86 years with various types of socially significant diseases were studied. All patients underwent thorough collection of clinical and anamnestic data, laboratory monitoring with the determination of the level of systolic and diastolic blood pressure (BP), body mass index, red blood, beta-2-microglobulin (B2M), lipid profile and proteinuria. Kidney function was assessed according to the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula using serum creatinine. The main group included 113 patients (55 men and 58 women, mean age 50.9±15.8 years), diagnosed with chronic kidney disease (CKD). The control group consisted of 171 people (63 men and 108 women) with various forms of socially significant diseases, but without signs of CKD. Statistical analysis was carried out using the programs Statistica 10.0 (StatSoft Inc., USA) and Microsoft Office Excel 2010 (Microsoft Corp., USA).Results. In the subgroup of patients with CKD, signs of renal failure were observed in 46 people in 40.7 % of cases. As CKD progressed, the signs of impaired metabolism of B2M were more severe: its serum level was 8.646 (7.892; 12.231) mg/l at C4 and 18.444 (11.225; 23.717) mg/l at C5 stages of CKD, and urinary excretion was 2.502 (0.305; 6.313) mg/l at C4 and 2.614 (1.535; 25.812) mg/l at C5 stages of CKD. Regardless of renal dysfunction, the median serum B2M level was clinically significantly higher in females (p>0.05). Single-factor one-way correlation analysis showed statistically highly significant relationship was between serum B2M and creatinine levels both in the subgroup of patients with CKD (r = 0.905; p = 0.001) and in the total sample (r = 0.749; p = 0.001). There was a strong negative relationship between serum B2M levels and estimated glomerular filtration rate (GFR) (r = -0.717; p = 0.001). In individuals without CKD, an increase in serum creatinine was closely associated with an increase in urinary excretion of B2M (r=0.252; p=0.005). Simultaneously, in this category of patients, there was a close correlation between estimated GFR with serum B2M level (r= -0.433; p=0.002) and its urinary excretion (r= -0.247; p=0.005). A direct relationship between an increase in serum B2M and an increase in diastolic blood pressure (r=0.274; p=0.034) among CKD patients was established. In the total sample, a direct relationship between the value of systolic BP and serum B2M level (r= 0.223; p=0.01) was registered, as well as between diastolic BP (r= 0.268; p=0.01) and urinary excretion of B2M.Conclusion. As a result of the study, metabolism of B2M and its relationship with the clinical and laboratory manifestations of CKD were evaluated. The data obtained show high prognostic potential of changes in metabolism of B2M in the population of patients with various forms of socially significant diseases, as well as CKD, which allows to identify among them groups of patients with high and/or very high renal and cardiovascular risk, in order to take timely targeted therapy.

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Kidney Tubules — Scientific and Applied Value

Cited by 3 publications

References 89 publications

Production tests of a sorption feed additive for rainbow trout

Production tests of a sorption feed additive for rainbow trout

Cardiorenal continuum: clinical and pathogenetic relationships between heart failure with preserved ejection fraction and renal tubular dysfunction

Role of beta 2 microglobulin in chronic kidney disease

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