2014
DOI: 10.1186/1476-4598-13-176
|View full text |Cite|
|
Sign up to set email alerts
|

KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer

Abstract: BackgroundLung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways for cellular transformation. We aimed to provide a basis for the further development of the therapy for KIF5B-RET positive lung cancer patients.MethodsRT-PCR was used to screen for KIF5B-RET fusi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
37
2

Year Published

2014
2014
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 52 publications
(39 citation statements)
references
References 35 publications
0
37
2
Order By: Relevance
“…ALK -fusions induce the activation of downstream canonical PI3K/AKT as well as MAPK/ERK pathways [ 29 ]. RET promotes cell growth through multilevel activation of STAT3 signaling [ 30 ]. Patients with ALK or RET fusion genes share many clinical characteristics, including lymphatic metastasis and subsequently worse prognoses [ 31 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…ALK -fusions induce the activation of downstream canonical PI3K/AKT as well as MAPK/ERK pathways [ 29 ]. RET promotes cell growth through multilevel activation of STAT3 signaling [ 30 ]. Patients with ALK or RET fusion genes share many clinical characteristics, including lymphatic metastasis and subsequently worse prognoses [ 31 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…1A). [26][27][28][29][30] RET is expressed in neurons, sympathetic and parasympathetic ganglia, thyroid C cells, adrenal medullary cells, urogenital tract cells, and testis germ cells. 31,32 It plays an important role in organogenesis and development of the enteric nervous system.…”
Section: Biology and Fusion Partnersmentioning
confidence: 99%
“…44 Among the downstream signals activated, preclinical models showed that RET fusion oncogenes (KIF5B-RET and CCDC6-RET) enhanced cell proliferation and survival through direct phosphorylation of signal transducer and activator of transcription 3 (STAT3) or activation of JAK/STAT3 and RAS/RAF/ MEK/ERK signaling pathways. 29 Figure 1B represents RET-KIF5B fusion protein activation and some triggered downstream pathways (RAS/MAPK, PI3K/AKT, and JAK/STAT) associated with cell survival, proliferation, migration, and differentiation.…”
Section: Biology and Fusion Partnersmentioning
confidence: 99%
“…The downstream targets of RET activation are thought to be the Ras/Raf/MEK and JAK/STAT pathways [23]. There are at least four FDA-approved tyrosine kinase inhibitors that have activity on the RET tyrosine kinase, ponatinib, sunitinib, vandetanib, and cabozantinib [2426].…”
Section: Ret Fusionsmentioning
confidence: 99%