KiGGS—the German survey on children's health as data base for reference intervals

Kohse, Klaus P.; Thamm, Michael

doi:10.1016/j.clinbiochem.2011.02.016

Cited by 17 publications

(6 citation statements)

References 2 publications

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“…Recently, the CALIPER study demonstrated the relationship between Abbott Architect assays and four other commonly used assays (Beckman Coulter, Ortho Vitros, Roche Cobas, and Siemens Vista) for a wide spectrum of biochemical markers ( 71 ). The pediatric health survey in Germany (KiGGS) is an another excellent example in this area ( 72 ). As these direct studies were well conducted and of large sample size, the current problems in pediatric RIs could be resolved through evaluation and application of the findings.…”

Section: Pediatric and Geriatric Reference Intervalsmentioning

confidence: 99%

Reference intervals: current status, recent developments and future considerations

2016

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Reliable and accurate reference intervals (RIs) for laboratory analyses are an integral part of the process of correct interpretation of clinical laboratory test results. RIs given in laboratory reports have an important role in aiding the clinician in interpreting test results in reference to values for healthy populations. Since the 1980s, the International Federation of Clinical Chemistry (IFCC) has been proactive in establishing recommendations to clarify the true significance of the term ‘RIs, to select the appropriate reference population and statistically analyse the data. The C28-A3 guideline published by the Clinical and Laboratory Standards Institute (CLSI) and IFCC is still the most widely-used source of reference in this area. In recent years, protocols additional to the Guideline have been published by the IFCC, Committee on Reference Intervals and Decision Limits (C-RIDL), including all details of multicenter studies on RIs to meet the requirements in this area. Multicentric RIs studies are the most important development in the area of RIs. Recently, the C-RIDL has performed many multicentric studies to obtain common RIs. Confusion of RIs and clinical decision limits (CDLs) remains an issue and pediatric and geriatric age groups are a significant problem. For future studies of RIs, the genetic effect would seem to be the most challenging area. The aim of the review is to present the current theory and practice of RIs, with special emphasis given to multicenter RIs studies, RIs studies for pediatric and geriatric age groups, clinical decision limits and partitioning by genetic effects on RIs.

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Section: Pediatric and Geriatric Reference Intervalsmentioning

confidence: 99%

Reference intervals: current status, recent developments and future considerations

2016

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“…Between 2003 and 2006, 17 641 children and adolescents aged between 0 and 17 years were examined as part of the German nationwide KiGGS study. The design, conduct, and findings of this study have been published in several places (23)(24)(25)(26)(27).…”

Section: Study Populationmentioning

confidence: 99%

The Prevalence of Celiac Disease in Children and Adolescents in Germany

Laaß

Schmitz²,

Uhlig³

et al. 2015

Deutsches Ärzteblatt International

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The 0.9% prevalence of celiac disease in Germany, as determined from a combination of serological findings and clinical histories, is similar to reported prevalences elsewhere in Europe and North America. Pediatricians, primary care physicians, internists, and other specialists should be aware of the broad spectrum of clinical manifestations of this disease. Children who have symptoms suggestive of celiac disease or belong to a group at risk for it should be tested for antibodies against tissue transglutaminase, as should symptomatic adults after the exclusion of other possible causes. It is not yet clear whether asymptomatic adults from high-risk groups should be tested.

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“…Separation into age groups with significant differences, however, invariably leads to a discontinuous representation of change with age. In the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), continuous reference intervals are reported for 28 analytes on the basis of a representative German cohort of 14 255 children (16,17 ). However, the critical age group of newborns and infants was excluded from blood sampling in the KiGGS survey for the ethical and practical reasons mentioned above.…”

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confidence: 99%

Age- and Sex-Specific Dynamics in 22 Hematologic and Biochemical Analytes from Birth to Adolescence

et al. 2015

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BACKGROUND Pediatric laboratory test results must be interpreted in the context of interindividual variation and age- and sex-dependent dynamics. Reference intervals as presently defined for separate age groups can only approximate the age-related dynamics encountered in pediatrics. Continuous reference intervals from birth to adulthood are not available for most laboratory analytes because of the ethical and practical constraints of defining reference intervals using a population of healthy community children. We applied an indirect method to generate continuous reference intervals for 22 hematologic and biochemical analytes by analyzing clinical laboratory data from blood samples taken during clinical care of patients. METHODS We included samples from 32 000 different inpatients and outpatients (167 000 samples per analyte) from a German pediatric tertiary care center. Measurements were performed on a Sysmex-XE 2100 and a Cobas Integra 800 during clinical care over a 6-year period. The distribution of samples considered normal was estimated with an established indirect statistical approach and used for the calculation of reference intervals. RESULTS We provide continuous reference intervals from birth to adulthood for 9 hematology analytes (hemoglobin, hematocrit, red cell indices, red cell count, red cell distribution width, white cell count, and platelet count) and 13 biochemical analytes (sodium, chloride, potassium, calcium, magnesium, phosphate, creatinine, aspartate transaminase, alanine transaminase, γ-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase, and total protein). CONCLUSIONS Continuous reference intervals capture the population changes in laboratory analytes during pediatric development more accurately than age groups. After local validation, the reference intervals provided should allow a more precise consideration of these dynamics in clinical decision making.

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KiGGS—the German survey on children's health as data base for reference intervals

Cited by 17 publications

References 2 publications

Reference intervals: current status, recent developments and future considerations

Reference intervals: current status, recent developments and future considerations

The Prevalence of Celiac Disease in Children and Adolescents in Germany

Age- and Sex-Specific Dynamics in 22 Hematologic and Biochemical Analytes from Birth to Adolescence

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