Kikuchi disease during pregnancy

Phupong, Vorapong; Poomtavorn, Yenrudee

doi:10.1007/s00404-006-0197-0

Cited by 7 publications

(12 citation statements)

References 14 publications

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“… 2–9 In these cases, no miscarriages were communicated. In some cases 2,6,9 KFD was diagnosed before pregnancy and it recurred during the next pregnancy. In our case, KFD was diagnosed outside of pregnancy and the patient suffered a new bout during the first trimester of her third pregnancy.…”

Section: Discussionmentioning

confidence: 88%

“…Recurrences during pregnancy have been described in four cases with good maternal and fetal outcomes 2,6,8,9 . There are scarce data concerning therapeutic requirements for this disease during pregnancy 5,6,9 . Recommended treatment is generally symptomatic, beginning with non‐steroidal anti‐inflammatory drugs (NSAIDs).…”

Section: Discussionmentioning

confidence: 99%

“…Although KFD affects young women of reproductive age, only few cases have been reported during pregnancy 2–9 . It has a self‐limiting clinical course, but recurrence has been described 2,6,9 . Some cases of KFD have evolved into systemic lupus erythematosus (SLE) during follow up 10 .…”

Section: Introductionmentioning

confidence: 99%

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Recurrent Kikuchi–Fujimoto disease during pregnancy: Report of case evolving into systemic lupus erythematosus and review of published work

Alijotas‐Reig

Casellas-Caro

Ferrer‐Oliveras

et al. 2008

J of Obstet and Gynaecol

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Kikuchi-Fujimoto disease (KFD) is a distinctive, benign type of necrotizing lymphadenitis. KFD is a rare entity, especially during pregnancy. Although first described in Japan, subsequently it has been reported in the West. We communicate herein a case of KFD in African women with bouts during pregnancy. Diagnosis was difficult because peripheral enlarged lymph nodes were absent and an extended differential diagnosis and adequate work-up was necessary. The patient suffered a miscarriage coinciding with a KFD bout. Further pregnancies were uneventful. Follow up showed that KFD evolved into a systemic lupus erythematosus-like syndrome.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Recurrent Kikuchi–Fujimoto disease during pregnancy: Report of case evolving into systemic lupus erythematosus and review of published work

Alijotas‐Reig

Casellas-Caro

Ferrer‐Oliveras

et al. 2008

J of Obstet and Gynaecol

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“…In addition, KFD is difficult to diagnose with fine-needle aspiration (13,54–57). Although recurrent lymphadenopathy suggests a diagnosis of KFD on clinical grounds, this may not be confirmed by pathological examination following LN excision (13,51), and some studies have reported a diagnosis of recurrent KFD based on clinical findings alone, without rebiopsy (3,13,42,51,58). The diagnostic criteria for recurrent KFD are therefore obscure.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease in the regional lymph nodes with node metastasis in a patient with tongue cancer: A case report and literature review

et al. 2017

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Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare self-limiting disorder typically affecting the cervical lymph nodes (LNs), which is often misdiagnosed as other LN-associated diseases. KFD frequently presents with necrotic lesions and recurrences, which are also features of metastatic LNs. Clinicians may thus suspect LN metastasis when they encounter ipsilateral cervical lymphadenopathy in a patient with head and neck cancer. The present study reports the case of a 48-year-old man with tongue cancer and KFD affecting the right edge of his tongue and ipsilateral cervical LNs. LN metastasis was initially suspected, but pathological examination of the dissected LNs revealed one necrotic metastatic lesion and two necrotic KFD lesions. Ipsilateral cervical lymphadenopathy recurred 6 years after the initial surgery, and it was not possible to differentiate clinically between a second primary tumor and recurrent KFD prior to treatment. To the best of our knowledge, this is the first reported case of simultaneous tongue cancer, regional LN metastasis and KFD. This highlights the requirement to consider KFD in the event of LNs with necrotic lesions but no cancerous cells. A combination of clinical and pathological approaches may aid in the diagnosis of KFD, in addition to ruling out LN metastasis in initial and recurrent lymphadenopathies. The present study indicate that a diagnosis of KFD should be considered in patients with head and neck cancer that exhibit necrotic LNs lacking cancerous cells. This is important, as misdiagnosis of KFD as LN metastasis may lead to unnecessary adjuvant therapy.

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“…The diagnosis is confirmed by lymph node biopsy, when histopathology reveals necrotizing lymphadenitis restricted to the cortical and paracortical areas, with partial or complete loss of follicular architecture, marked karyorrhexis and absence of neutrophils, granulomatous reaction or lymphoma cells [5]. Most KFD cases improve within a six-month period [3], and a wide range of recurrence rates have been reported, from 4% to 27% [10-12]. …”

Section: Discussionmentioning

confidence: 99%

Bilateral pleural effusion and interstitial lung disease as unusual manifestations of kikuchi-fujimoto disease: case report and literature review

Garcia-Zamalloa¹,

Taboada-Gómez²,

Bernardo-Galán³

et al. 2010

BMC Pulm Med

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BackgroundKikuchi-Fujimoto's disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare, idiopathic and self-limited condition usually characterized by cervical lymphadenopathy and fever, most often affecting young patients. Aetiology is unknown. Differential diagnosis includes mainly malignant lymphoma, tuberculous lymphadenitis and systemic lupus erythematosus (SLE), so early diagnosis is crucial. Pleuropulmonary involvement due to isolated KFD has been seldom reported.Case Presentationa 32-year-old man, on treatment for iatrogenic hypothyroidism, was admitted due to high grade fever and painful cervical lymphadenopathies. KFD was diagnosed by lymph node biopsy. Some days after admission the patient got worse, he developed generalized lymphadenopathy, bilateral pleural effusion and interstitial lung disease. All of them resolved with prednisone and after two years of following up he remains asymptomatic and without evidence of any other associated disease.ConclusionPleural effusion and interstitial lung disease are very uncommon manifestations of KFD. In our experience, treatment with oral prednisone was effective.

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Kikuchi disease during pregnancy

Abstract: This is the fourth reported case of Kikuchi disease developing during pregnancy. When Kikuchi disease occurs in a pregnant woman, there is neither any effect of disease on the pregnant woman nor the fetus.

Cited by 7 publications

References 14 publications

Recurrent Kikuchi–Fujimoto disease during pregnancy: Report of case evolving into systemic lupus erythematosus and review of published work

Recurrent Kikuchi–Fujimoto disease during pregnancy: Report of case evolving into systemic lupus erythematosus and review of published work

Kikuchi-Fujimoto disease in the regional lymph nodes with node metastasis in a patient with tongue cancer: A case report and literature review

Bilateral pleural effusion and interstitial lung disease as unusual manifestations of kikuchi-fujimoto disease: case report and literature review

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