Kikuchi-Fujimoto disease: an unusual cause of neck swelling in pregnancy

Mayooran, Nithiananthan; O’Cathain, Eadaoin; Bresnihan, Mary; Patil, Naishadh

doi:10.1136/bcr-2014-206505

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…It is essential to exclude the following conditions from the differential diagnosis of lymphadenopathy during pregnancy [ 31 , 32 ]. Studies have shown that flare-ups of SLE are more likely to occur during pregnancy [ 33 ].…”

Section: Reviewmentioning

confidence: 99%

The Evaluation of Lymphadenopathy in a Resource-Limited Setting

Ali¹,

Elhatw²,

Hegazy³

et al. 2022

Cureus

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Lymphadenopathy (LAP) refers to abnormalities in the size or consistency of lymph nodes. A wide range of etiologies contributes to the difficulty in diagnosing LAP, from mild self-limited viral infections to grave autoimmune diseases and malignancies. Detailed history-taking and a thorough physical examination are essential. Some physicians in developing countries may consider therapeutic testing. Certain groups may require additional evaluations and special treatment. When treating LAP, the etiology is targeted, but corticosteroids should not be administered before a complete diagnosis has been established due to their ability to mask the histological diagnosis of lymphoma and malignancy. This review aims to provide more straightforward and affordable methods available in almost all healthcare settings, especially those with limited resources.

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Section: Reviewmentioning

confidence: 99%

The Evaluation of Lymphadenopathy in a Resource-Limited Setting

Ali¹,

Elhatw²,

Hegazy³

et al. 2022

Cureus

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“…Only a small number of cases have been reported in the UK 14. A literature search conducted in the BMJ Case Notes reported 14 previous cases, and of those 14, 3 were in the UK and 1 in the Ireland 15 16…”

Section: Discussionmentioning

confidence: 99%

TB or not to be? Kikuchi-Fujimoto disease: a rare but important differential for TB

McKenna¹,

Whitfield

Patel

et al. 2017

BMJ Case Reports

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A 29-year-old British Pakistani woman presented with a 2-month history of drenching fevers, night sweats, lethargy and tender cervical and axillary lymphadenopathy. Initial investigations, bloods and imaging were unremarkable. Fever persisted during her admission, and treatment for tuberculosis (TB) lymphadenitis was started postbiopsy until histology confirmed a diagnosis of Kikuchi-Fujimoto's disease (KFD). KFD has a non-specific presentation of fever, night sweats and lymphadenopathy and commonly raises a clinical suspicion of a number of other serious conditions such as TB, lymphoma, HIV, systemic lupus erythematous, toxoplasmosis and infectious mononucleosis. Although rare, KFD should be considered to be a differential diagnosis for fever of unknown origin and tender lymphadenopathy in otherwise well individuals. This case demonstrates the importance of a timely histological biopsy diagnosis to prevent an incorrect diagnosis and administration of unnecessary medications.

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Kikuchi–Fujimoto disease during early pregnancy

Ichikawa,

Negishi,

Chishima

et al. 2024

J of Obstet and Gynaecol

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Kikuchi–Fujimoto disease (KFD) is rare during pregnancy. It is characterized by necrotizing lymphadenitis and often occurs in young Asian women. We report a case of KFD during pregnancy, which was difficult to diagnose. A 37‐year‐old pregnant female (gestational week [GW] 7+5) was admitted to our hospital because of hyperemesis gravidarum. On the eighth day of hospitalization (GW 8+6), she suddenly developed a fever (38.0°C) with skin rash and posterior pharynx redness. Blood tests showed pancytopenia and abnormal liver function. The patient was misdiagnosed with severe Epstein–Barr virus infection and administered with prednisolone. Subsequently, cervical lymphadenopathy was observed, and biopsy results led to the diagnosis of KFD. Thereafter, her symptoms improved, and she was discharged at GW 13+4. KFD must be included as a differential diagnosis for patients with fever, abnormal liver function, and pancytopenia during pregnancy.

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Kikuchi-Fujimoto disease: an unusual cause of neck swelling in pregnancy

Cited by 3 publications

References 14 publications

The Evaluation of Lymphadenopathy in a Resource-Limited Setting

The Evaluation of Lymphadenopathy in a Resource-Limited Setting

TB or not to be? Kikuchi-Fujimoto disease: a rare but important differential for TB

Kikuchi–Fujimoto disease during early pregnancy

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