Kikuchi-Fujimoto Disease- Clinicopathological Analysis of 35 Cases

Abstract

BACKGROUNDKikuchi-Fujimoto disease has become a common cause of lymphadenopathy in many parts of the world. The cause and pathogenesis still remains a mystery. Systemic morphological studies of the disease are few from India. Aims of this study were-1. To delineate the clinical and lab features as well as lymph node morphology of Kikuchi-Fujimoto disease and to compare the above features with previous studies. 2. To compare the proliferative subtype of the disease with high-grade lymphoma and devise a scoring system that aids in differential diagnosis. MATERIALS AND METHODS35 consecutive patients diagnosed to have Kikuchi-Fujimoto Disease on lymph node biopsy in Calicut Medical College during the period January 2006 to December 2007 were evaluated for their clinical details. Their lymph node biopsies were reassessed; 15 lymph node biopsies reported as high-grade non-Hodgkin lymphoma were compared with proliferative subtype of Kikuchi Fujimoto Disease. RESULTSThe mean age in the study was 25.4 years with female: male ratio of 2.5. Cervical nodes were involved in almost all the cases. Significant number of cases were associated with leukopaenia. Of the 35 cases 17 were proliferative type (48.6%), 16 were necrotising type (45.7%) and 2 were xanthomatous type (5.7%). A scoring system was devised for discriminating between KFD and high-grade lymphoma noting certain microscopic features.

Chronic Fever with Recurent Cervical Cystic Lymphadenitis as Long COVID-19 Alertness to Kikuchi-Fujimoto Disease and Autoimmune Disease in the Future

“…There were five distinct areas in lymph nodes affected by KFD in this study: follicles, paracortex (normal or hyperplastic), proliferation centres, geographic necrosis and foam cell collections. (28) Cystic lymphadenitis, also known as necrotic lymphadenitis was found in our patient. The presence of dominant histiocytes with a starry sky appearance in our patient may indicate KFD.…”