Kikuchi-Fujimoto Disease in a 30-Year-Old Caucasian Female

Archibald, David; Carlson, Matthew L.; Gustafson, Ray O.

doi:10.1155/2009/901537

Cited by 19 publications

(36 citation statements)

References 14 publications

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“…We used the keywords ("PET/CT" or "position emission tomography-CT" or " 18 FDG" or " 18 fluorodeoxyglucose") and ["KFD" or "Kikuchi-Fujimoto disease" or "Kikuchi's disease" or "histiocytic necrotizing lymphadenitis") [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Role of PET/CT in the Diagnosis of Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature

Mghanga¹,

Bakari²,

Mayala³

2017

J Mol Imaging Dynam

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Introduction: Kikuchi-Fujimoto disease (KFD), also known as Kikuchi's disease or histiocytic necrotizing lymphadenitis, is a self-limiting case of non-cancerous lymphadenopathy. Although previous reports have demonstrated its physical findings and traditional imaging characteristics, few studies mentioned the application of 18 fluorodeoxyglucose positron emission tomography-computed tomography ( 18 F-FDG PET/CT) imaging in the diagnosis and follow-up of this disease. Here, we present three cases of KFD, describe the findings from PET/CT images and review relevant literature to improve the diagnosis of this rare disease.

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Section: Introductionmentioning

confidence: 99%

The Role of PET/CT in the Diagnosis of Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature

Mghanga¹,

Bakari²,

Mayala³

2017

J Mol Imaging Dynam

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“…There are no specifi c assays available to confi rm the diagnosis of KFD. 14 The radiographic diagnosis of KFD is broad and includes Hodgkin and non-Hodgkin disease, metastatic tumor, tuberculosis, nontuberculous mycobacterial infection, SLE, human immunodefi ciency virus infection, infectious mononucleosis, cat-scratch disease, mucocutaneous lymph node syndrome (Kawasaki disease), and toxoplasmosis. In one series, 29% of patients with KFD were initially misdiagnosed as having Hodgkin or non-Hodgkin disease.…”

Section: Discussionmentioning

confidence: 99%

“…In one series, 29% of patients with KFD were initially misdiagnosed as having Hodgkin or non-Hodgkin disease. 14 The differential diagnosis of a slow-growing neck mass is broad and includes malignant lymphoma, systemic lupus erythematosus (SLE), Hodgkin disease, toxoplasmosis, metastatic carcinoma, infectious mononucleosis, acquired immunodeficiency syndrome, cat-scratch disease, and angioimmunoblastic lymphadenopathy. 14 KFD is different from lymphoma, especially in early stages, in which there are few necrosis zones and also immunoblasts originating among nuclear debris.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease: an unusual association with acute renal failure

Silva¹,

Focaccia²,

Oliveira³

et al. 2010

Braz J Infect Dis

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Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis of unknown etiopathogenesis, is a self-limited disease which frequently appears as feverish lymphadenomegaly, thus creating the need for differential diagnosis with lymphoma, systemic lupus erythematosus (SLE), infectious mononucleosis, cat-scratch disease, and toxoplasmosis with lymphonodal impairment. However, there are cases in which it may evolve with complications such as aseptic meningitis, cerebellar ataxia, and aseptic myocarditis. We are presenting a case of a 24-year-old man who had an initial picture of arthralgia, evening fever and adenomegaly. Kikuchi disease was diagnosed through lymph node biopsy with immunohistochemistry and evolves with severe systemic manifestations, such as pericarditis with cardiac tamponade, pneumonitis, hepatitis, and acute kidney failure - the latter has not been reported in literature yet. There was significant improvement of the clinical picture with prednison

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“…11 It was reported in 1972 in Japan by Kikuchi and Fujimoto who described the disease independently as "lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis" and "cervical subacute necrotizing lymphadenitis," respectively. 12 Although KFD was initially thought to be occurring exclusively in the cervical lymph nodes of young Asian women, it has been seen in patients of any age, sex, and race, and can involve nodal and extranodal locations also. 12 Most of the case reports are of Asian origin young females between 20 years and 35 years of age.…”

Section: Kikuchi-fujimoto Diseasementioning

confidence: 99%

“…12 Although KFD was initially thought to be occurring exclusively in the cervical lymph nodes of young Asian women, it has been seen in patients of any age, sex, and race, and can involve nodal and extranodal locations also. 12 Most of the case reports are of Asian origin young females between 20 years and 35 years of age. The male:female ratio is 1:21.…”

Section: Kikuchi-fujimoto Diseasementioning

confidence: 99%

Cervical lymphadenopathies: a diagnostic crisis

2017

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Cervical lymphadenopathy refers to lymphadenopathy of the cervical lymph nodes. The causes are varied, and may be inflammatory, degenerative, infective or neoplastic. The first case presented here is of a 29-year old male presented with h/o recurrent progressive right sided painless swelling in the infraparotid region with cervical lymphadenopathy for past one year. Swelling was 6×6cm, nontender, firm mass. Cervical lymph nodes were palpable. He had raised eosinophil counts and elevated serum IgE levels. Biopsy showed abundant eosinophilic infiltration with microabscess suggestive of Kimura’s disease. Second case reported here is of a 17-year old female patient presented with fever for 3 weeks with cervical lymphadenopathy. The lymph node was 3×2cm, tender and firm. Routine blood investigations showed anemia. Biopsy showed lymph nodes composed of sheets of macrophages with crescent shaped nuclei with areas of necrosis and karyhorrhexis suggestive of Kikuchi’s disease. Kimura’s disease is a relatively uncommon chronic inflammatory benign condition mostly affecting the lymph nodes, subcutaneous tissue and salivary glands of head and neck region. It is seen in males in their second decade of lives. Peripheral eosinophilia, regional lymphadenopathy and elevated serum IgE levels are characteristics of Kimura’s disease. Kikuchi-Fujimoto disease is a benign, idiopathic and self-limited disease. Affects young females between 20-35 years of age. Usually there will be localized painful lymphadenopathy, fever and leukopenia. Kikuchi disease runs a benign course and resolves in several weeks to months. The two cases are presented to make clinicians aware of Kimura’s disease and Kikuchi’s disease as a differential diagnosis of cervical lymphadenopathy and to avoid the diagnostic dilemma both clinically and histopathologically.

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Kikuchi-Fujimoto Disease in a 30-Year-Old Caucasian Female

Cited by 19 publications

References 14 publications

The Role of PET/CT in the Diagnosis of Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature

The Role of PET/CT in the Diagnosis of Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature

Kikuchi-Fujimoto disease: an unusual association with acute renal failure

Cervical lymphadenopathies: a diagnostic crisis

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