Kikuchi-Fujimoto disease in children: two case reports and a review of the literature

Lelii, Mara; Senatore, Laura; Amodeo, Ilaria; Pinzani, Raffaella; Torretta, Sara; Fiori, Stefano; Marchisio, Paola; Bosis, Samantha

doi:10.1186/s13052-018-0522-9

Cited by 26 publications

(25 citation statements)

References 35 publications

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“…1,2 Systemic changes are more likely with extranodal involvement and include night sweats, chills, weight loss, generalised lymphadenopathy, arthralgia, rash and neurological involvement. [3][4][5] Although most patients have a benign course, symptoms can be prolonged and complications such as haemophagocytic lymphohistiocytosis have been reported. 3,5 As the symptoms are non-specific, differential diagnoses such as viral infections (Epstein-Barr virus, cytomegalovirus), malignancies such as lymphoma and autoimmune conditions such as systemic lupus erythematosus (SLE) are often considered.…”

Section: What This Paper Addsmentioning

confidence: 99%

“…Kikuchi‐Fujimoto disease (KFD), also known as histiocytic necrotising lymphadenitis, is generally a benign self‐limited disease of unknown aetiology characterised by fever and cervical lymphadenopathy . Systemic changes are more likely with extranodal involvement and include night sweats, chills, weight loss, generalised lymphadenopathy, arthralgia, rash and neurological involvement . Although most patients have a benign course, symptoms can be prolonged and complications such as haemophagocytic lymphohistiocytosis have been reported .…”

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confidence: 99%

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Kikuchi‐Fujimoto disease in children

Selvanathan

Suhumaran

Sahu

et al. 2019

J Paediatrics Child Health

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Aim Kikuchi‐Fujimoto disease (KFD) is an important cause of lymphadenitis in children. The primary aim of this study was to investigate the clinical characteristics of children with KFD and to assess the recurrence of this disease. Methods This is a retrospective study of patients younger than 18 years old, who were diagnosed with KFD from January 2000 to September 2017 at KK Women's and Children's Hospital. Records of children with a histological diagnosis of KFD from a lymph node biopsy were obtained from the Department of Pathology. Case notes and electronic medical records of the patients were reviewed. Data collected included patient characteristics, symptoms, clinical and laboratory findings, treatment and follow‐up. Results A total of 98 patients were identified. There were 52 boys and 46 girls with a median age of 11.2 years old. Recurrence occurred in 12 (12.2%) patients. One patient developed systemic lupus erythematosus 10 years after diagnosis of KFD. Recurrent cases were more likely to be managed as an inpatient and have fever at presentation of their first episode of KFD. Conclusion In our study, KFD in children had a higher prevalence among boys, and had a recurrence rate of 12.2%, with 1% of patients developing systemic lupus erythematosus. We recommend that patients be followed up for recurrence and advised to monitor for symptoms of recurrence.

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Section: What This Paper Addsmentioning

confidence: 99%

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confidence: 99%

Kikuchi‐Fujimoto disease in children

Selvanathan

Suhumaran

Sahu

et al. 2019

J Paediatrics Child Health

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“…The etiology and pathogenesis of Kikuchi Fujimoto disease is not known and there are no criteria developed for diagnosis of this (Lelii et al, 2018). The most common inding is leukopenia, followed by atypical lymphocytes; however, in majority of patients Complete Blood Cell count is normal.…”

Section: Resultsmentioning

confidence: 99%

“…Kikuchi-Fujimoto disease (KFD) a rare , idiopathic and self limiting cause of lymphadenitis. It is also known as histiocytic necrotizing lymphadenitis (Lelii et al, 2018). The etiology of KFD is unknown but theories suggest that it is caused by one or more unidenti ied agents.…”

Section: Introductionmentioning

confidence: 99%

A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease

Raj¹,

Ravi²,

Roshni³

et al. 2020

ijrps

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Kikuchi-Fujimoto disease also known as necrotizing lymphadenitis is a rare, self limiting cause of lymphadenitis with unknown etiology and pathogenesis. The clinical signs and symptoms include cervical lymphadenopathy, fever, less frequent chills, night sweats, arthralgia, rash, weight loss and symptoms of respiratory infections. Diagnosis is often based on histopathological studies involving lymph node. It is often misdiagnosed with SLE, Lymphoma etc. There is no treatment guidelines given for KFD after diagnosis it is often limited to treat the symptoms but in severe cases corticosteroids can be given. Here we discuss a 14yr old female patient presented with evening rise of temperature and significant weight loss of approximately 5kg. Along with that she has also complained about bilateral axillary swelling of small size with pain. The final diagnosis was based on lymph node biopsy indicating Kikuchi-Fujimoto disease also the laboratory values were also elevated. After diagnosis patient was treated with symptomatically and the condition of the patient also improved. Although Kikuchi-Fujimoto disease can be misdiagnosed with other diseases, a systematic diagnostic approach is needed. Since there is no specific guidelines available for the management of Kikuchi-Fujimoto disease, further studies are needed to conduct the therapeutic option and its long term outcome.

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“…2 KFD is a rare and benign disease with unknown etiology. 4 Although the etiology of disease is still unclear, viral infections (Epstein-Barr virus, Cytomegalovirus, rhinovirus, rubella virus, and HIV) 5 and autoimmune diseases (SLE, Polymyositis, Rheumatoid arthritis, Still's disease, and Sjogren's syndrome) 6 are proposed as possible triggers for KFD. The most common clinical presentations of KFD are lymphadenopathy (79-94%), fever (35-67%), cutaneous rashes (4-32.9%), arthralgia (7-34.1%), and hepatosplenomegaly (3-14.8%).…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 in a case with Kikuchi‐Fujimoto disease

Jaseb

Fard

Rezaei

et al. 2021

Clinical Case Reports

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Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a rare and self-limiting benign disease. 1 KFD is mostly seen in young adults before the age of 30 years with a female predominance, 2 but in children, it is more common in boys. 1 KFD is typically characterized by cervical lymphadenopathy, fever, and skin rash. 3 The etiology of KFD is still unknown, and it can lead to misdiagnosis with other diseases, including lymphoma, systemic lupus erythematosus, or hematological disorders. 4 Although supportive therapy is usually enough for management of KFD, 2 the misdiagnosis can impose patients to unnecessary diagnostic procedures and treatments. In this study, we present a case of Kikuchi-Fujimoto disease that was also positive for novel coronavirus disease 2019 (COVID-19).

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Kikuchi-Fujimoto disease in children: two case reports and a review of the literature

Cited by 26 publications

References 35 publications

Kikuchi‐Fujimoto disease in children

Kikuchi‐Fujimoto disease in children

A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease

COVID‐19 in a case with Kikuchi‐Fujimoto disease

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