Kikuchi-Fujimoto Disease With Encephalopathy in Children: Case Reports and Literature Review

Pan, Yuting; Xu, Yan; Fan, Zhidan; Yu, Haiguo

doi:10.3389/fped.2021.727411

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Nineteen pediatric patients were identified, including two patients we presented (Table 1). 2,4–13 Eight patients were males and eleven patients were females. The onset age ranges from 6 to 18 years (the median age was 14 and the interquartile range was 9–16).…”

Section: Resultsmentioning

confidence: 99%

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Kikuchi–Fujimoto disease associated with the central nervous system in children

Huang

Wang

et al. 2023

Pediatric Discovery

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The clinical data of patients with Kikuchi–Fujimoto disease (KFD) combined with the involvement of the central system is limited, particularly for children. This study aimed to investigate the clinical features and prognosis of KFD associated with the central nervous system in children. We collected the clinical data of patients diagnosed with KFD combined with the involvement of the central system, hospitalized at Children's Hospital of Chongqing Medical University (CHCMU). Furthermore, we summarized the clinical features and outcomes in children by reviewing the published literature. Together with the two patients from CHMCU enrolled in this study, we identified 19 children diagnosed with KFD combined with the involvement of the central nervous system, including eight males and 11 females. The onset age ranges from 6 to 18 years (the median age was 14 and the interquartile range was 9–16). Sixteen patients were diagnosed with aseptic meningitis. Headache (78.9%, 15/19) was the most common symptom. Cerebrospinal fluid pressure was increased in 3 patients (60.0%, 3/5), cell count was elevated in 14 patients (73.7%, 14/19), glucose was decreased in 4 patients (21.0%, 4/19), and protein was elevated in 12 patients (63.1%, 12/19). A total of 9 patients had cranial imaging changes. Electroencephalogram (EEG) was performed on seven patients and 4 patients presented abnormal EEG (57.1%, 4/7). A total of 12 patients received steroid therapy; two were combined with antiepileptic treatment. In children, KFD complicated with the involvement of the central nervous system was rare and aseptic meningitis was the primary manifestation. Most patients had a good prognosis and a few had residual sequelae of neurological damage.

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Section: Resultsmentioning

confidence: 99%

“…2,[4][5][6][7][8][9][10][11][12][13] Eight patients were males and eleven patients were females. The onset age ranges from 6 to 18 years (the median age was 14 and the interquartile range was 9-16).…”

mentioning

confidence: 99%

Kikuchi–Fujimoto disease associated with the central nervous system in children

Huang

Wang

et al. 2023

Pediatric Discovery

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“…Encephalopathy in KFD is uncommon. One study found 9 cases reported in children between 2010 and 2020. Another large case series reported an incidence of neurological complications of 4.5% in KFD, most commonly aseptic meningitis.…”

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confidence: 99%

A Rare Neurological Presentation of Kikuchi-Fujimoto Disease

Asad,

Mehta,

Mallon

2024

JAMA Neurol

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The Skin and Disorders of the Haematopoietic and Immune Systems

Basu,

Kulasekararaj

2024

Rook's Textbook of Dermatology

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In this chapter the cutaneous manifestations of malignant and benign haematological disease are reviewed, as well as skin disorders associated with primary and acquired immunodeficiency. The vast array of skin manifestations associated with disorders of the haematopoietic and immune systems highlights the importance of close collaboration between dermatology, haematology and immunology teams to enable the delivery of optimal multidisciplinary patient care.

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Kikuchi-Fujimoto Disease With Encephalopathy in Children: Case Reports and Literature Review

Cited by 4 publications

References 25 publications

Kikuchi–Fujimoto disease associated with the central nervous system in children

Kikuchi–Fujimoto disease associated with the central nervous system in children

A Rare Neurological Presentation of Kikuchi-Fujimoto Disease

The Skin and Disorders of the Haematopoietic and Immune Systems

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