Kikuchi-Fujimoto’s disease: a case series from Sri Lanka

Abeysekara, R. A.; Kularatne, S.A.M.; Waduge, Roshitha; Sandeepana, A G W; Bandara, J M R P; Imbulpitiya, I V B

doi:10.4038/cmj.v58i1.5362

Cited by 5 publications

(7 citation statements)

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“…showed a female predominance with a male to female ratio on 1:1.32. Other studies reporting a female predominance involved studies from Nepal and Sri Lanka which may be related to racial variations and the small numbers reported in the series . A total of 59.2% of our patients were between 7 and 12 years old, while 35.7% of them presented between 12 and 18 years old, with a median age of 11.2 years old.…”

Section: Discussioncontrasting

confidence: 52%

“…Other studies reporting a female predominance involved studies from Nepal and Sri Lanka which may be related to racial variations and the small numbers reported in the series. 18,19 A total of 59.2% of our patients were between 7 and 12 years old, while 35.7% of them presented between 12 and 18 years old, with a median age of 11.2 years old. This is similar to the mean ages in other studies that have ranged from 11 years old to 13.2 years old.…”

Section: Discussionmentioning

confidence: 78%

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Kikuchi‐Fujimoto disease in children

Selvanathan

Suhumaran

Sahu

et al. 2019

J Paediatrics Child Health

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Aim Kikuchi‐Fujimoto disease (KFD) is an important cause of lymphadenitis in children. The primary aim of this study was to investigate the clinical characteristics of children with KFD and to assess the recurrence of this disease. Methods This is a retrospective study of patients younger than 18 years old, who were diagnosed with KFD from January 2000 to September 2017 at KK Women's and Children's Hospital. Records of children with a histological diagnosis of KFD from a lymph node biopsy were obtained from the Department of Pathology. Case notes and electronic medical records of the patients were reviewed. Data collected included patient characteristics, symptoms, clinical and laboratory findings, treatment and follow‐up. Results A total of 98 patients were identified. There were 52 boys and 46 girls with a median age of 11.2 years old. Recurrence occurred in 12 (12.2%) patients. One patient developed systemic lupus erythematosus 10 years after diagnosis of KFD. Recurrent cases were more likely to be managed as an inpatient and have fever at presentation of their first episode of KFD. Conclusion In our study, KFD in children had a higher prevalence among boys, and had a recurrence rate of 12.2%, with 1% of patients developing systemic lupus erythematosus. We recommend that patients be followed up for recurrence and advised to monitor for symptoms of recurrence.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 78%

Kikuchi‐Fujimoto disease in children

Selvanathan

Suhumaran

Sahu

et al. 2019

J Paediatrics Child Health

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“…Younger females were noted to be more predisposed to KFD in our study with ages ranging from 4-38 years, all considerably younger than their male counterpart in this study. A study of 9 patients was conducted in Sri Lanka by Abeysekara R A et al, where all the cases were female patients in the age group of 12-30 years 13 . A similar study was carried out by Adhikari R C et al, in Nepal where 5 of the 6 cases were females and the age range was 13-32 years 14 .…”

Section: Resultsmentioning

confidence: 99%

Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India 

Achappa¹,

Herath²,

Kini³

et al. 2020

Preprint

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Background Kikuchi-Fujimoto disease is a rare, benign condition, of unknown etiology, presenting as cervical lymphadenitis, usually tender and maybe associated with systemic symptoms. Despite the extensive literature on this disease, it continues to be misdiagnosed owing to its misleading clinical presentation. Results The mean age in our study was 26.9 (±11.3) years with a female majority of 65.7%. The clinical presentation of most cases was, tender swelling over the side of the neck ( n =50, 74.6%). On local examination, the mean length and width were 2.3 (±1.0) cm and 2.2 (±0.7) cm respectively. Histopathological examination revealed that most patients presented in the proliferative stage ( n =40, 59.7%). In 83.6% of the patients lymphadenopathy resolved in less than 2 months. Follow up of these patients over 9 months revealed that a vast majority of the patients underwent full recovery with symptomatic treatment ( n =42, 62.7%). Conclusions The disease is prevalent in young, female patients of Asian descent and often presents as cervical lymphadenopathy. Early diagnosis with excisional lymph node biopsy is crucial to avoid unnecessary investigations and treatment. Treatment is only symptomatic unless complicated, where steroid therapy is considered. Kikuchi’s disease has an excellent prognosis with almost no risk of fatality.

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“…Abeysekara et al . described nine cases showing histopathological features of Kikuchi’s disease in Sri Lanka [ 5 ]. All patients were female, in the age group of 12 to 30 years, and had fever and lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

“…Kikuchi Fujimoto disease (KFD) is an uncommon benign condition of necrotizing histiocytic lymphadenitis commonly seen in East Asian and Japanese populations [ 1 – 5 ]. Although many bacteria, viruses, and autoimmune conditions were attributed to its etiopathogenesis, none of these were consistently associated with the condition [ 6 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Fever with lymphadenopathy – Kikuchi Fujimoto disease, a great masquerader: a case report

Dalugama

Gawarammana

2017

J Med Case Reports

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BackgroundKikuchi Fujimoto disease is an uncommon benign condition of necrotizing histiocytic lymphadenitis commonly seen in East Asian and Japanese populations. It commonly presents with fever, cervical lymphadenopathy, and elevated inflammatory markers. Diagnosis of Kikuchi Fujimoto disease is based on histopathological studies of the involved lymph nodes. The presentation of Kikuchi Fujimoto disease can mimic many sinister conditions including lymphoma. Treatment is mainly supportive provided that accurate diagnosis is made and sinister conditions like lymphoma ruled out.Case presentationWe report the case of an 18-year-old Sri Lankan Moor woman who presented with fever and cervical lymphadenopathy for 1 month. She had elevated inflammatory markers with high lactate dehydrogenase and ferritin levels. She had an extensive work-up including an excision biopsy of an involved lymph node and bone marrow biopsy. Finally, a diagnosis of Kikuchi Fujimoto disease was based on histopathology of the lymph node and negative bone marrow biopsy.ConclusionsAlthough Kikuchi Fujimoto disease is a self-limiting condition, it is a great masquerader which mimics the clinical features of many sinister conditions including tuberculosis, lymphoma, and adult-onset Still’s disease. Early recognition of the disease is of crucial importance in minimizing potentially harmful and unnecessary evaluations and treatments.

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Kikuchi-Fujimoto’s disease: a case series from Sri Lanka

Cited by 5 publications

References 11 publications

Kikuchi‐Fujimoto disease in children

Kikuchi‐Fujimoto disease in children

Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India

Fever with lymphadenopathy – Kikuchi Fujimoto disease, a great masquerader: a case report

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Kikuchi-Fujimoto’s disease: a case series from Sri Lanka

Cited by 5 publications

References 11 publications

Kikuchi‐Fujimoto disease in children

Kikuchi‐Fujimoto disease in children

Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India&nbsp;

Fever with lymphadenopathy – Kikuchi Fujimoto disease, a great masquerader: a case report

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Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India