Kikuchi-Fujimoto’s disease with abdominal pain due to intra-abdominal lymphadenitis

Noda, Ayako; Kenzaka, Tsuneaki; Sakatani, Takashi; Kajii, Eiji

doi:10.1136/bcr-2013-203017

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…Although lymphadenopathy in KFD is usually localized to cervical lymph nodes, it can occasionally be generalized with involvement of other nodes . KFD also may rarely involve intra‐abdominal lymph nodes; only 29 cases have been reported previously . More than half of these cases were associated with generalized lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

“…Kikuchi–Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign self‐limiting disorder of unknown cause that manifests as prolonged fever and cervical lymphadenopathy . Recurrence of KFD or involvement of other lymph nodes is rare, but has been previously reported . Multiple recurrences, however, are extremely rare and there are no reports of migratory recurrence of KFD.…”

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confidence: 99%

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Multiple migratory recurrence of Kikuchi–Fujimoto disease

Handa

Nozaki

Hosoya

et al. 2016

Pediatrics International

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Multiple migratory recurrence of Kikuchi–Fujimoto disease

Handa

Nozaki

Hosoya

et al. 2016

Pediatrics International

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“…However, more than 47 cases of intra-abdominal KFD have been described in the literature. Of those, most had mesenteric lymphadenopathies, and concomitant extra-abdominal lymphadenopathies were often present 7 14–16…”

Section: Discussionmentioning

confidence: 99%

Abdominal Kikuchi-Fujimoto lymphadenopathy: an uncommon presentation of a rare disease

et al. 2022

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A 34-year-old man presented to our hospital with a 5-day history of progressive abdominal pain and fever. A CT scan identified extensive mesenteric lymphadenopathy. Initial diagnostic tests were inconclusive. Abdominal lymph node biopsy showed histiocytic necrotising lymphadenitis, compatible with Kikuchi-Fujimoto disease (KFD). This benign and self-limiting disease generally resolves following supportive treatment. In this case, remission occurred within 3 weeks of initial presentation. KFD is a very uncommon cause of lymphadenopathy, and selective mesenteric involvement is rare. Definitive diagnosis often requires lymph node biopsy. It is important to exclude more common and serious differential diagnoses associated with mesenteric lymphadenopathy, while maintaining a minimally invasive diagnostic approach, before progressing to nodal biopsy.

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“…Abdominal lymphadenopathy is reported in 2.1% of pediatric patients, which is slightly lower than in adults, where abdominal lymphadenopathy is reported in 2.6%-4.3% of KD cases. 20 It is likely that these figures are underestimations, since imaging of extracervical regions is not always performed and abdominal lymphadenopathy can be asymptomatic. Chen et al analyzed data from 60 patients with confirmed KD (median age, 21 years) in whom imaging was performed.…”

Section: Lymphadenopathymentioning

confidence: 99%

“…21 An analysis of published adult cases showed that of 21 cases with abdominal lymphadenopathy, 11 (52%) also had superficial lymphadenopathy. 20 The authors advise avoiding, if possible, the highly invasive excision biopsy of intraabdominal lymph nodes given the benign nature of KD. 20 Tenderness of the lymph nodes is not reported consistently, but based on studies where it is mentioned explicitly (n = 16), 61% of children (204/334) experience painful lymph nodes.…”

Section: Lymphadenopathymentioning

confidence: 99%

Kikuchi Disease in Children

Abdu

Bijker

2021

Pediatric Infectious Disease Journal

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Background: Kikuchi disease (KD) is a rare and generally benign condition of uncertain etiology that presents with nonspecific symptoms including fever and cervical lymphadenopathy. Clinical presentations can vary. Here, we present an atypical case of KD in a 10-year-old girl, as well as an updated literature review of the clinical presentation, laboratory features and management of KD in children. Methods: Studies (published up until February 2020) were identified through searches of PubMed using the following search items: Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis or Kikuchi disease. Our primary search resulted in 1117 publications. A total of 34 publications with a total of 670 patients were included in the final analysis. Results: All children present with lymphadenopathy. Almost all (96.3%) have cervical lymphadenopathy. Fever is recorded in the majority of children (77.1%). Analysis of laboratory features found that the majority of children have leukopenia (56.0%) and a raised erythrocyte sedimentation rate (56.0%). Over 30% have a raised C-reactive protein and anemia. Other features such as leukocytosis, thrombocytopenia and antinuclear antibodies positivity are less common. KD is mostly self-limiting, but steroids, hydroxychloroquine and intravenous immunoglobulin are used in protracted courses. Their efficacy has yet to be established in clinical trials. Conclusions:The presentation of KD is variable, and there is no specific set of symptoms or laboratory features that reliably establishes the diagnosis. Thus, histopathology is crucial. Definitive evaluation and establishment of effective treatments will require future prospective research studies for a more comprehensive description of the clinical course and effects of treatment. Given the rarity of the disease, this will have to be performed in collaborative consortia.

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Kikuchi-Fujimoto’s disease with abdominal pain due to intra-abdominal lymphadenitis

Cited by 4 publications

References 8 publications

Multiple migratory recurrence of Kikuchi–Fujimoto disease

Multiple migratory recurrence of Kikuchi–Fujimoto disease

Abdominal Kikuchi-Fujimoto lymphadenopathy: an uncommon presentation of a rare disease

Kikuchi Disease in Children

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