Kill three birds with one stone: Mitochondria-localized tea saponin derived carbon dots with AIE properties for stable detection of HSA and extremely acidic pH

Zhang, Shengtao; Li, Bin; Zhou, Jieyu; He, Zhongjing; Zhao, Yuhai; Li, Yan; Shen, Yehua; Wu, Shaoping; Zhang, Yongmin

doi:10.1016/j.foodchem.2022.134865

Cited by 25 publications

(7 citation statements)

References 38 publications

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“…As shown in Figure 5a, when excited at 208 nm, the maximum fluorescence emission peak of free MoS 2 NFs appeared at 637 nm. This phenomenon was similar to that reported in previous literatures [35] . As concentration of BSA increased, the fluorescence of MoS 2 NFs at 637 nm gradually decreased, and the fluorescence at 358 nm was weakly enhanced.…”

Section: Resultssupporting

confidence: 92%

“…BSA and HAS share 76 % sequence homology and have the same binding sites on the subdomains IIA and IIIA. Trp‐214 in HSA and Trp‐212 in BSA are located in similar hydrophobic microenvironments in subdomain IIA and are often used as probes to monitor drug binding interactions within albumin [35] …”

Section: Introductionmentioning

confidence: 99%

“…Trp-214 in HSA and Trp-212 in BSA are located in similar hydrophobic microenvironments in subdomain IIA and are often used as probes to monitor drug binding interactions within albumin. [35] In this paper, MoS 2 nanoflowers (NFs) were prepared by hydrothermal method with NH 2 CSNH 2 and Na 2 MoO 4 • 2H 2 O as precursors, and their structures were characterized. Then, the interaction between BSA and MoS 2 NFs was studied by spectroscopic techniques.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterizations of MoS₂ Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

Ma,

Guan,

Cui

et al. 2024

Chemistry & Biodiversity

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Molybdenum disulfide nanoflowers (MoS2 NFs) were prepared by hydrothermal method. The prepared MoS2 NFs was characterized by SEM, TEM, XRD, specific surface areas, Raman and XPS. The characterization results show that the flower‐like spherical MoS2 is composed of many ultra‐thin nanosheets with an average diameter of about 300‐400 nm. MoS2 NFs also exhibits excellent absorption and high fluorescence intensity. In order to explore the biological behavior of MoS2 NFs, the interaction between MoS2 NFs and bovine serum albumin (BSA) was studied by UV–Vis absorption, fluorescence, synchronous fluorescence spectra, and cyclic voltammetry. The results of absorption and fluorescence show that MoS2 NFs and BSA interact strongly through the formation of complexes. The Stern–Volmer constant and the quenching constant was calculated about 3.79×107 L mol−1 and 3.79×1015 L mol−1 s−1, respectively. The synchronous fluorescence implied that MoS2 in the complex may mainly bind to tryptophan residues of BSA. The cyclic voltammograms indicated that the addition of BSA makes electron reduction of MoS2 NFs more difficult than the corresponding free state. These experimental results clarified the effective transportation and elimination of MoS2 NFs in the body by binding to BSA, and can provide useful guideline for estimating MoS2 NFs as a drug carrier.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterizations of MoS₂ Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

Ma,

Guan,

Cui

et al. 2024

Chemistry & Biodiversity

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“…In addition, the low fluorescence intensity might have been attributed to deprotonation under pH 11.0–12.0 (Figure S5b). − The fluorescence intensity of the AuAgNCs was stable in water and methanol (Figure S5c) but was affected by highly polar solvents . The presence of different oxidizing or reducing agents caused slight fluctuations in the fluorescence intensity of the AuAgNCs (Figure S5d), indicating that they were not susceptible to oxidation or reduction.…”

Section: Resultsmentioning

confidence: 99%

A Ratiometric Fluorescent Sensor for Penicillin G Based on Color-Tunable Gold–Silver Nanoclusters

Yeh,

Lin,

Chiu

et al. 2024

ACS Omega

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Excessive administration of penicillin G and improper disposal of its residues pose a serious risk to human health; therefore, the development of convenient methods for monitoring penicillin G levels in products is essential. Herein, novel gold−silver nanoclusters (AuAgNCs) were synthesized using chicken egg white and 6-aza-2thiothymine as dual ligands with strong yellow fluorescence at 509 and 689 nm for the highly selective detection of penicillin G. The AuAgNCs were characterized using transmission electron microscopy, X-ray photoelectron spectroscopy, ultraviolet−visible absorption spectrophotometry, and fluorescence spectrophotometry. Under optimum conditions, the fluorescence intensity decreased linearly with the concentration of penicillin G from 0.2 to 6 μM, with a low detection limit of 18 nM. Real sample analyses indicated that a sensor developed using the AuAgNCs could detect penicillin G in urine and water samples within 10 min, with the recoveries ranging from 99.7 to 104.0%. The particle size of the AuAgNCs increased from 1.80 to 9.06 nm in the presence of penicillin G. We believe the aggregation-induced quenching of the fluorescence of the AuAgNCs was the main mechanism for the detection of penicillin G. These results demonstrate the ability of our sensor for monitoring penicillin G levels in environmental and clinic samples.

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“…In addition, carbon dots can precisely localize at certain cellular structures, such as the nucleolus, 35 mitochondria, 36,37 lysosomes, 38,39 and endoplasmic reticulum. 40 Lysosomes are acidic organelles; 41,42 any changes in lysosomal pH can lead to lysosomal dysfunction and contribute to the development of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of high-brightness red carbon quantum dots for pH and oxidized l-glutathione dual response

Cao

et al. 2023

Analyst

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Kill three birds with one stone: Mitochondria-localized tea saponin derived carbon dots with AIE properties for stable detection of HSA and extremely acidic pH

Cited by 25 publications

References 38 publications

Synthesis and Characterizations of MoS₂ Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

Synthesis and Characterizations of MoS₂ Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

A Ratiometric Fluorescent Sensor for Penicillin G Based on Color-Tunable Gold–Silver Nanoclusters

Preparation and application of high-brightness red carbon quantum dots for pH and oxidized l-glutathione dual response

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Kill three birds with one stone: Mitochondria-localized tea saponin derived carbon dots with AIE properties for stable detection of HSA and extremely acidic pH

Cited by 25 publications

References 38 publications

Synthesis and Characterizations of MoS2 Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

Synthesis and Characterizations of MoS2 Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

A Ratiometric Fluorescent Sensor for Penicillin G Based on Color-Tunable Gold–Silver Nanoclusters

Preparation and application of high-brightness red carbon quantum dots for pH and oxidized l-glutathione dual response

Contact Info

Product

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About

Synthesis and Characterizations of MoS₂ Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin

Synthesis and Characterizations of MoS₂ Nanoflowers and Spectroscopic Study of their Interaction with Bovine Serum Albumin