Killer cell immunoglobulin-like receptor (KIR) locus profiles in the Tunisian population

Bani, Maria Rosa; Jihen, Seket; Houda, Kaabi; Cherif, G.; Chaabane, Manel; Bellali, Hedi; Hmida, Slama

doi:10.1016/j.humimm.2015.03.002

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…Similar results were also reported in Southern Brazil [ 61 , 62 ] and Eastern Han populations in China [ 63 ]. Moreover, the AA genotype profile was the most frequent among our study participants similar to previously reported data in healthy unrelated individuals in Lebanon [ 57 ], Turkey [ 60 ], Iran [ 58 ], and Tunisia [ 64 ].…”

Section: Discussionsupporting

confidence: 89%

Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities

Hassan

Hamdan

Asmar

et al. 2022

Journal of Immunology Research

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Combined antiretroviral therapy (cART) increased the life expectancy of people living with HIV (PLHIV) and remarkably reduced the morbidity and mortality associated with HIV infection. However, non-AIDS associated comorbidities including diabetes, hypertension, hyperlipidemia, and cardiovascular diseases (CVD) are increasingly reported among PLHIV receiving cART. Killer cell immunoglobulin receptors (KIRs) expressed on the surface of natural killer (NK) cells have been previously implicated in controlling HIV disease progression. The aim of this study is to investigate the role of KIRs in developing non-AIDS associated comorbidities among PLHIV. Demographic and behavioral data were collected from voluntary participants using a standardized questionnaire. Whole blood samples were collected for KIR genotyping. Hypertension (29.5%) and hyperlipidemia (29.5%) followed by diabetes (23.7%) and CVD (9.7%) were mainly reported among our study participants with higher rate of comorbid conditions observed among participants > 40 years old. The observed KIR frequency (OF) was ≥90% for inhibitory KIR2DL1 and KIR3DL1, activating KIR2DS4 and the pseudogene KIR2DP1 among study participants. We detected significant differences in the expression of KIR3DS4 and KIR3DL1 ( p = 0.038 ) between diabetic and nondiabetic and in the expression of KIR2DL3 between hypertensive and normotensive HIV-infected individuals ( p = 0.047 ). Moreover, KIR2DL1 and KIR2DP1 were associated with significantly reduced odds of having CVD (OR 0.08; 95% CI: 0.01-0.69; p = 0.022 ). Our study suggests the potential role of KIR in predisposition to non-AIDS comorbidities among PLHIV and underscores the need for more studies to further elucidate the role of KIRs in this population.

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Section: Discussionsupporting

confidence: 89%

Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities

Hassan

Hamdan

Asmar

et al. 2022

Journal of Immunology Research

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“…Such comparisons may be used to determine the genetic relationships among populations from different geographic areas. In the study population, the frequencies of the KIR genes varied from 31.5% ( KIR2DS5 ) to 97.4% ( KIR2DP1 and KIR2DL1 ) and were similar to those identified in Lebanese, Tunisian, and Iranian populations 51,55,60 . The clustering of different populations based on the KIR gene carrier frequencies as indicated by PCA suggests that the carrier frequencies in the Kuwaiti population is most similar to published frequencies observed in Lebanese, Omani and Saudi followed by US Caucasian populations 49,58,60,63 .…”

Section: Discussionsupporting

confidence: 69%

“…In the study population, the frequencies of the KIR genes varied from 31.5% (KIR2DS5) to 97.4% (KIR2DP1 and KIR2DL1) and were similar to those identified in Lebanese, Tunisian, and Iranian populations. 51,55,60 The clustering of different populations based on the KIR gene carrier frequencies as indicated by PCA suggests that the carrier frequencies in the Kuwaiti population is most similar to published frequencies observed in Lebanese, Omani and Saudi followed by US Caucasian populations. 49,58,60,63 This similarity might be at least in part due to historic immigration and intermarriages among individuals of these neighboring populations.…”

Section: Discussionmentioning

confidence: 62%

“…Sugioka et al observed in a study of a Brazilian population that specific inhibitory and activating genes had different frequencies in healthy donor family members compared to patients and suggested that susceptibility to leukemia could be influenced partly by KIR receptors. 20 The aim of this study is to (1) characterize KIR haplotypes in Kuwaiti subjects by haplotype segregation in families and compare haplotype frequencies with published data from other populations, 36,46 (2) compare the frequency of the KIR genes among a cohort of HCT recipients and healthy Kuwaiti volunteer donors from the Kuwaiti unrelated donor registry (3) compare the frequency of the KIR genes in healthy Kuwaiti volunteer donors to published frequencies in other populations, 36,[47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] and (4) investigate the generalizability of the observed differences in KIR gene carrier frequency among patients with hematological malignancies and healthy donors in the Brazilian population were generalizable to other populations such as Kuwaitis. 20 Findings of this study may guide future research investigating the importance of the KIR genes and their associations with particular diseases and potentially KIR based HCT donor selection strategies.…”

Section: Introductionmentioning

confidence: 99%

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KIR genotype and haplotype repertoire in Kuwaiti healthy donors, hematopoietic cell transplant recipients and healthy family members

Ameen

Titus

Geo

et al. 2023

HLA

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The gene complex located on chromosome 19q13.4 encodes the Killer-cell Immunoglobulin-like Receptors (KIRs), which exhibit remarkable polymorphism in both gene content and sequences. Further, the repertoire of KIR genes varies within and between populations, creating a diverse pool of KIR genotypes. This study was carried out to characterize KIR genotypes and haplotypes among 379 Arab Kuwaiti individuals including 60 subjects from 20 trio families, 49 hematopoietic cell transplantation (HCT) recipients and 270 healthy Kuwaiti volunteer HCT donors. KIR Genotyping was performed

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Polymorphism in killer cell immunoglobulin-like receptors and human leukocyte antigen-c and predisposition to preeclampsia in Ethiopian pregnant women population

Kelemu

Erlandsson

Seifu

et al. 2020

Journal of Reproductive Immunology

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Killer cell immunoglobulin-like receptor (KIR) locus profiles in the Tunisian population

Cited by 7 publications

References 62 publications

Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities

Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities

KIR genotype and haplotype repertoire in Kuwaiti healthy donors, hematopoietic cell transplant recipients and healthy family members

Polymorphism in killer cell immunoglobulin-like receptors and human leukocyte antigen-c and predisposition to preeclampsia in Ethiopian pregnant women population

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