Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria

Olaniyan, Subulade A.; Amodu, Olukemi K.; Yindom, L M; Conway, David J.; Aka, Peter; Bakare, Adekunle A.; Omotade, Olayemi O.

doi:10.1016/j.humimm.2014.06.002

Cited by 9 publications

(9 citation statements)

References 36 publications

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“…In the same way, NK and γδT lymphocytes produce IFNγ and TNFα in malaria patients ( D’Ombrain et al, 2007 ; Horowitz et al, 2010 ; Stanisic et al, 2014 ), while polymorphisms within the natural killer cell complex modulate mouse cerebral malaria ( Hansen et al, 2014 ). In humans, the effect of NK polymorphisms on severe malaria has been poorly investigated, and yielded conflicting results ( Olaniyan et al, 2014 ; Yindom et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

Thiam

Baaklini

Mbengué

et al. 2018

PeerJ

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BackgroundHost factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.MethodsBlood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed.ResultsWe evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients.ConclusionsOur results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes.

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Section: Discussionmentioning

confidence: 99%

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

Thiam

Baaklini

Mbengué

et al. 2018

PeerJ

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“…Similarly, AB heterozygosity was suggested to be protective during clinical malaria infection, as individuals carrying c-AB2/t-AA (i.e., individuals with heterozygous A and B centromeric KIR genes in combination with telomeric A haplotype genes) were more likely to have asymptomatic malaria infections rather than uncomplicated or severe symptomatic malaria (146). As carriage of both A and B haplotypes is likely to increase the total number of different KIR that can be an expressed by an individual, heterozygosity may increase the proportion of NK cells that express a KIR capable of binding self-HLA and are therefore “licensed” [reviewed in Ref.…”

Section: Heterogeneity In Nk Cell Responses To Malariamentioning

confidence: 99%

NK Cells: Uncertain Allies against Malaria

2017

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Until recently, studies of natural killer (NK) cells in infection have focused almost entirely on their role in viral infections. However, there is an increasing awareness of the potential for NK cells to contribute to the control of a wider range of pathogens, including intracellular parasites such as Plasmodium spp. Given the high prevalence of parasitic diseases in the developing world and the devastating effects these pathogens have on large numbers of vulnerable people, investigating interactions between NK cells and parasitized host cells presents the opportunity to reveal novel immunological mechanisms with the potential to aid efforts to eradicate these diseases. The capacity of NK cells to produce inflammatory cytokines early after malaria infection, as well as a possible role in direct cytotoxic killing of malaria-infected cells, suggests a beneficial impact of NK cells in this disease. However, NK cells may also contribute to overproduction of pro-inflammatory cytokines and the consequent immunopathology. As comparatively little is known about the role of NK cells later in the course of infection, and growing evidence suggests that heterogeneity in NK cell responses to malaria may be influenced by KIR/HLA interactions, a better understanding of the mechanisms by which NK cells might directly interact with parasitized cells may reveal a new role for these cells in the course of malaria infection.

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“…Nigerian populations were also included in subsequent studies such as genome-wide association studies (GWAS) or post-GWAS studies for various cardiometabolic disorders (Adeyemo et al, 2015;Chen et al, 2017;Kang et al, 2010;Nandakumar et al, 2017;Reder et al, 2012;Tayo, Luke, Zhu, Adeyemo, & Cooper, 2009;Tayo et al, 2013). Studies of host genetic risk factors for infectious disease have also been done in Nigerian populations, especially in relation to malaria (Amodu et al, 2005(Amodu et al, , 2012Olaniyan et al, 2014Olaniyan et al, , 2016, including some in the context of international consortia such as MalariaGen (Olaniyan et al, 2014;Clarke et al, 2017).…”

Section: Nigeriamentioning

confidence: 99%