Killer Cell Lectin-Like Receptors and the Natural Killer Cell Gene Complex

Nylenna, Øyvind; Flornes, Line Mari; Westgaard, Ingunn H.; Woon, Peng Yeong; Naper, Christian; Vaage, John T.; Guyader, Dominique; Ryan, James C.; Dissen, Erik; Fossum, Sigbjørn

doi:10.1007/0-387-25515-x_7

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“…The releases of the sequences amassed by the international genome projects finally exposed the real size of this gene complex in different species. Thus, aided by the Rat Genome project, we could report that the genetic region spanning from the most centromeric Nkrp1 to the most telomeric Ly49 gene covered 3.3 Mb, with a predicted content of 67 CLSF genes (Nylenna et al 2005a ). However, although the conservation of sequence features among the many intraspecific paralogs and interspecific orthologs has greatly facilitated prediction of novel CLSF genes, in silico prediction is error prone and uninformative as to whether the predicted genes are expressed.…”

Section: Introductionmentioning

confidence: 99%

The complete inventory of receptors encoded by the rat natural killer cell gene complex

et al. 2010

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The natural killer cell gene complex (NKC) encodes receptors belonging to the C-type lectin superfamily expressed primarily by NK cells and other leukocytes. In the rat, the chromosomal region that starts with the Nkrp1a locus and ends with the Ly49i8 locus is predicted to contain 67 group V C-type lectin superfamily genes, making it one of the largest congregation of paralogous genes in vertebrates. Based on physical proximity and phylogenetic relationships between these genes, the rat NKC can be divided into four major parts. We have previously reported the cDNA cloning of the majority of the genes belonging to the centromeric Nkrp1/Clr cluster and the two telomeric groups, the Klre1–Klri2 and the Ly49 clusters. Here, we close the gap between the Nkrp1/Clr and the Klre1–Klri2 clusters by presenting the cDNA cloning and transcription patterns of eight genes spanning from Cd69 to Dectin1, including the novel Clec2m gene. The definition, organization, and evolution of the rat NKC are discussed.Electronic supplementary materialThe online version of this article (doi:10.1007/s00251-010-0455-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%