2004
DOI: 10.1016/j.coi.2004.07.010
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Killer immunoglobulin-like receptors

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Cited by 306 publications
(237 citation statements)
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“…Activation of NK cells is tightly controlled by the balance between inhibitory and activating receptors (9). Among them, KIR, CD94/NKG2A, and LILRB1 are specific for HLA class I (HLA-I) molecules and prevent NK cell activation against healthy host cells (10,11). During HCMV replication a set of viral proteins (i.e., US2, US3, US6, US10, US11) inhibit surface expression of HLA-I in infected cells (12).…”
Section: H Uman CMV (Hcmv) Is a B-herpesvirus That Infects 40-mentioning
confidence: 99%
“…Activation of NK cells is tightly controlled by the balance between inhibitory and activating receptors (9). Among them, KIR, CD94/NKG2A, and LILRB1 are specific for HLA class I (HLA-I) molecules and prevent NK cell activation against healthy host cells (10,11). During HCMV replication a set of viral proteins (i.e., US2, US3, US6, US10, US11) inhibit surface expression of HLA-I in infected cells (12).…”
Section: H Uman CMV (Hcmv) Is a B-herpesvirus That Infects 40-mentioning
confidence: 99%
“…17 Both HLA-A and -C genes are interesting candidates for a direct role in MS pathogenesis, as their encoded molecules present antigenic peptides and interact with NK receptors. 18,19 However, several other genes in this region might be primarily associated with MS. The 1.3 Mb interval within HLA-A and -C genes contains 46 genes (24% of which encoding molecules involved in immune functions) and about 4000 SNPs, according to the recently reported sequence of eight HLA ancestral haplotypes 20 and HapMap data (http://www.hapmap.…”
Section: Hla-class I Markers Involved In Ms Susceptibility L Bergamasmentioning
confidence: 99%
“…3 The structural basis for NK cell-mediated allorecognition are MHC class I-specific inhibitory receptors, namely killer Ig-like receptors (KIR) and the lectin-like CD94:NKG2A heterodimer, which are both expressed in a clonally distributed mode (1). The clonal distribution of NK cell receptors leads to a repertoire, which is highly diverse in terms of receptor combinations on different clones.…”
Section: Relevance Of C1 and C2 Epitopes For Hemopoietic Stem Cell Trmentioning
confidence: 99%