Killing pain? A prospective population-based study on trauma exposure in childhood as predictor for frequent use of over-the-counter analgesics in young adulthood. The HUNT study

Baumann-Larsen, Monica; Zwart, John-Anker; Dyb, Grete; Wentzel-Larsen, Tore; Stangeland, Helle; Storheim, Kjersti; Stensland, Synne Øien

doi:10.1016/j.psychres.2023.115400

Cited by 4 publications

(1 citation statement)

References 73 publications

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“…6,29,64 Recent results from a large, prospective study on the relation of childhood trauma to subsequent use of over-thecounter analgesics are consistent with these findings, with results indicating an increased risk of frequent use of over-the-counter analgesics among young adults exposed to childhood trauma. 9 Trauma types representing interpersonal violence, such as bullying, sexual abuse, and physical violence, and particularly multiple types of such trauma, have been found to be especially strongly associated with frequent use of over-the-counter analgesics. 8 Such cumulative load may be of importance for the relation to analgesics use also for other trauma types.…”

Section: Introductionmentioning

confidence: 99%

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study

Baumann-Larsen,

Storheim,

Stangeland

et al. 2024

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Opioid and nonopioid analgesics are commonly prescribed to young people to alleviate pain. Even short-term prescriptions increase the risk of persistent use and future misuse of potent analgesics, such as opioids. Childhood trauma exposure has been found to be related to pain conditions and to using more prescription analgesics. This large, prospective cohort study aimed to investigate the association of a broad range of childhood trauma exposures with prescription rates for opioid and nonopioid analgesics in adolescence and young adulthood. Self-reported data on childhood trauma exposures from adolescents (aged 13-19 years) who participated in the Young-HUNT3 Study (2006-2008, n = 8199) were linked to data from the Norwegian Prescription Database (NorPD, 2004-2021). We found that exposure to childhood trauma was consistently associated with higher prescription rates for opioids throughout adolescence and young adulthood. The highest incidence rate ratio (IRR) in adolescence was observed for sexual abuse (IRR 1.63, confidence interval [CI] 1.19-2.23). In young adulthood, the highest IRR was observed for physical violence (2.66, CI 2.27-3.12). The same overall pattern was observed for nonopioid analgesics. The more frequent prescriptions of opioid and nonopioid analgesics to participants exposed to childhood trauma suggests a higher symptom load of pain causing them to seek professional help with pain relief. Receiving potent analgesics is not without risk, and the likelihood of misuse may be elevated among trauma-exposed individuals. A trauma-informed approach to pain could be vital for guiding clinicians to the most effective and least harmful treatment for each patient.

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Section: Introductionmentioning

confidence: 99%

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study

Baumann-Larsen,

Storheim,

Stangeland

et al. 2024

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Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review

Senaratne,

Koponen,

Barnett

et al. 2024

British Journal of Anaesthesia

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Over-the-counter analgesic usage: associations with attentional biases in young women

Roalsø,

Klonteig,

Kraft

et al. 2024

Behavioural Pharmacology

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The use of over-the-counter analgesics (OTCA) has been found to alter various aspects of emotional processing and has been linked to increased anxiety and depression symptoms. Attentional bias is an aspect of emotional processing that is closely related to anxiety and depression. Although OTCA and attentional bias have both been linked to anxiety and depression, the potential links between OTCA usage and attentional bias are not yet investigated. The present study aimed to determine whether the frequency of OTCA usage is associated with differences in attentional bias by comparing response-based measures of attentional bias in 62 women aged 19–30 years. The findings showed that the small group reporting high OTCA usage demonstrated more orientation avoidance to fearful stimuli than those reporting no or low usage. Based on these preliminary findings, further research on attentional bias and its relationship to high OTCA usage is recommended.

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Killing pain? A prospective population-based study on trauma exposure in childhood as predictor for frequent use of over-the-counter analgesics in young adulthood. The HUNT study

Cited by 4 publications

References 73 publications

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study

Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review

Over-the-counter analgesic usage: associations with attentional biases in young women

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