Kimchi and soybean pastes are risk factors of gastric cancer

Nan, Hongmei; Park, Jin Woo; Song, Young Jin; Yun, Hyo Yung; Park, Joo Seung; Hyun, Taisun; Youn, Sei Jin; Kim, Yong Dae; Kang, Jong Won; Kim, Heon

doi:10.3748/wjg.v11.i21.3175

Cited by 84 publications

(55 citation statements)

References 46 publications

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“…SNPs of CYP1A1 termed as m1 (at 1,188 bp 3 ¶ of the stop codon) and m2 (I462V) have been often found associated with risk in several smoking-related tumors (3). Only two case control studies have reported results for gastric cancer in relation with m2 mutation: one in Korea observed a weak but significant 34% increase in risk (17), whereas no association was found in a study in Japan (18). We observed a tendency to decreased risk for both m1 (significant among smokers) and m2 mutations.…”

Section: Discussioncontrasting

confidence: 58%

“…Deletion of GSTT1 was found not to be associated with gastric cancer risk in several studies in a variety of populations (17,(20)(21)(22)(23)(24)(25)(26)(27). One study in Poland found a significant increase in risk for null GSTT1 limited to cases with age <50 years (28); another study in China reported a significant OR of 2.5 for GSTT1 deletion (29).…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Agudo¹,

Sala

Pera³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C>A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus À3859G>A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (Cancer Epidemiol Biomarkers Prev

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Agudo¹,

Sala

Pera³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Finally, 39 articles that report on the effects of GSTT1 polymorphisms on gastric cancer in Asia covering in total of 7,737 gastric cancer cases and 10,823 controls were remained for data extraction. 11 of them were Chinese (Qian et al, 2001; Sheng and Wang, 2002;Zheng et al, 2002;Liu et al, 2003;Ye et al, 2003;Zhang et al, 2003;Zhou et al, 2003;Xie et al, 2008; Feng et al, 2010; Liu et al, 2013;Shi et al, 2014), and 28 were English (Katoh et al, 1996;Setiawan et al, 2000; Cai et al, 2001;Saadat and Saadat, 2001; Gao et al, 2002a;Wu et al, 2002; Choi et al, 2003;Roth et al, 2004;Mu et al, 2005;Nan et al, 2005a; Sheng et al, 2005;Tamer et al, 2005; Hong et al, 2006; Al-Moundhri et al, 2009;Malik et al, 2009;Masoudi et al, 2009;Moy et al, 2009;Piao et al, 2009;Nguyen et al, 2010;Yadav et al, 2010;Luo et al, 2011;Tripathi et al, 2011;Yadav et al, 2011;Zhang et al, 2011; Jing et al, 2012;Malakar et al, 2012; Eom et al, 2013; Haholu et al, 2013). The characteristics of included studies were summarized in Table 1.…”

Section: Study Selection and Study Characteristicsmentioning

confidence: 99%

Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

Zeng

Bai²,

Deng³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: A large number of studies have been published to investigate the association between the null genotype of glutathione S-transferase T1 (GSTT1) with gastric cancer. However, the results were inconsistent and conflicting. The aim of this study was to estimate the relationship between this polymorphism in the GSTT1 gene and gastric cancer risk in Asian populations by meta-analysis. Materials and Methods: A literature search was performed in PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang database, and China National Knowledge Infrastructure database (CNKI). Statistical analysis was conducted by using Review Manager 5.3. Results: Thirty-nine studies with a total of 7,737 gastric cancer cases and 10,823 controls were included in this meta-analysis. The meta-analysis of total studies showed that the null genotype in GSTT1 was associated with increased risk of gastric cancer in Asians (OR=1.19, 95% CI=1.08-1.31, p=0.0002). Subgroup analysis showed a significant relationship between GSTT1 null genotype and gastric cancer in East-Asians, as well as in subgroup analysis of hospital-based design. On subgroup analysis by smoking status, alcohol status, Helicobacter pylori infection status, and histology type, no significant association of this polymorphism with susceptibility to gastric cancer was found. Conclusions: In conclusion, the results showed that the null genotype of GSTT1 is significantly associated with an increased risk in gastric cancer in Asian populations. (Acar et al., 2006;Sreeja et al., 2008;Liu et al., 2010). Polymorphisms in this gene affect the enzymatic activities and the ability to metabolize carcinogenic compounds (Nebert et al., 1999). The most common variant of GSTT1 gene is homozygous deletion (null genotype), which has been reported to be associated with gastric cancer (Hayes and Strange, 2000). However, the sparseness of data or disagreements among the reported investigations results in the available evidence weakly. To assess the effect of GSTT1 null genotype on gastric cancer risk in Asian population more precisely, we conducted most of the related studies and performed this meta-analysis of published data investigating whether the null genotype of GSTT1 gene was associated with the risk of gastric cancer. Keywords Materials and Methods Publication searchA literature search of PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang 1142database and Chinese National Knowledge Infrastructure (CNKI) was conducted using combinations of the following keywords: "gastric cancer or gastric carcinoma or gastric neoplasm" and "polymorphism or variant or mutation" and "GSTT1 or glutathione S-transferase T1". The language was limited to Chinese and English. All studies that evaluate the relationship between polymorphisms in GSTT1 gene and gastric cancer risk were retrieved. Studies included in the meta-analysis had to meet all of the following criteria: (1) evaluation of the polymorphisms in GSTT1 gene and gastric cancer risk, (2) use of ...

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“…In epidemiologic studies, the health benefits of soy for gastric cancer are inconsistent: some studies reported that soy products, such as bean and tofu, significantly decrease the risk of gastric cancer (4,5,13), whereas other studies reported that soy products were not significantly associated with a decreased risk of gastric cancer (14)(15)(16)(17). The inconsistency for dietary intake might be due to the use of food frequency questionnaires and the case-control design.…”

Section: Introductionmentioning

confidence: 99%

Isoflavones from Phytoestrogens and Gastric Cancer Risk: A Nested Case-Control Study within the Korean Multicenter Cancer Cohort

Park

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The role of soybean products in gastric cancer risk is not clear in epidemiologic studies due to measurement error from dietary intake questionnaires and due to different degrees of bias according to study design. To examine the association between soybean products and gastric cancer risk, we measured phytoestrogen biological markers in a nested case-control study.Methods: The study population was composed of 131 cases and 393 matched controls within the Korean Multicenter Cancer Cohort. The concentrations of the four biomarkers in the plasma samples were measured using time-resolved fluoroimmunoassay. Conditional and unconditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence intervals (CI).Results: Median plasma concentrations of genistein (229 nmol/L for controls, 181.8 nmol/L for cases; P = 0.07) and daidzein (131.2 nmol/L for controls, 80.5 nmol/L for cases; P = 0.04) in cases were lower than in controls, whereas equol concentrations were similar. Compared with the reference group, gastric cancer risk decreased in the highest groups for genistein (OR, 0.54; 95% CI, 0.31-0.93) and daidzein (OR, 0.21; 95% CI, 0.08-0.58). Higher equol concentrations were associated with a decreased risk for gastric cancer (OR, 0.50; 95% CI, 0.27-0.90). The combination of the highest concentrations for each isoflavone category was associated with a 0.09-fold decreased risk for gastric cancer compared with the combination of the lowest concentrations for each category. There was no association between plasma lignan concentrations and gastric cancer.Conclusions: High serum concentrations of isoflavones were associated with a decreased risk for gastric cancer. Impact: These results suggest a beneficial effect of high soybean product intake for gastric cancer risk.

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Kimchi and soybean pastes are risk factors of gastric cancer

Cited by 84 publications

References 46 publications

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

Isoflavones from Phytoestrogens and Gastric Cancer Risk: A Nested Case-Control Study within the Korean Multicenter Cancer Cohort

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