Kimesurface representation and tensor linear modeling of longitudinal data

Abstract

Many modern techniques for analyzing time-varying longitudinal data rely on parametric models to interrogate the timecourses of univariate or multivariate processes. Typical analytic objectives include utilizing retrospective observations to model current trends, predict prospective trajectories, derive categorical traits, or characterize various relations. Among the many mathematical, statistical, and computational strategies for analyzing longitudinal data, tensor-based linear modeling offers a unique algebraic approach that encodes different characterizations of the observed measurements in terms of state indices. This paper introduces a new method of representing, modeling, and analyzing repeated-measurement longitudinal data using a generalization of event order from the positive reals to the complex plane. Using complex time (kime), we transform classical time-varying signals as 2D manifolds called kimesurfaces. This kime characterization extends the classical protocols for analyzing time-series data and offers unique opportunities to design novel inference, prediction, classification, and regression techniques based on the corresponding kimesurface manifolds. We define complex time and illustrate alternative time-series to kimesurface transformations. Using the Laplace transform and its inverse, we demonstrate the bijective mapping between time-series and kimesurfaces. A proposed general tensor regression based linear model is validated using functional Magnetic Resonance Imaging data. This kimesurface representation method can be used with a wide range of machine learning algorithms, artificial intelligence tools, analytical approaches, and inferential techniques to interrogate multivariate, complex-domain, and complex-range longitudinal processes.