Kimura Disease - A Rare Case

Abstract

Kimura's disease is a unique chronic inflammatory angiolymphoid proliferative disorder with a poorly understood pathogenesis occasionally misdiagnosed as malignant tumour or other serious diseases. It is more prevalent in young oriental males, presenting with sub dermal lesions in the head and neck, lymphadenopathy, eosinophilia and elevated serum Immunoglobulin E. We report a case of a 40 year old female presenting with a left infra auricular swelling, based on clinical, histopathological and laboratory findings, a diagnosis of Kimura's disease was made. The patient responded well to surgery and followed by post operative long term low dose steroids and antihistaminics during the last 18 months of follow up period.

Kimura’s Disease- Clinico / Histopathological Study in Head and Neck Region

“…DOI: 10.18410/jebmh/2018/610 BACKGROUND Kimura Disease (KD) is a rare chronic inflammatory disorder, which was first described in 1937 by Kim and Szeto in the Chinese literature as "eosinophilic hyperplastic lymphogranuloma" and has been known most often as Kimura's disease since its description by Kimura et al in the Japanese literature in 1948. 1,2 The most common clinical feature of this disease is a soft-tissue mass in the head and neck area, with major salivary glands and lymph nodes frequently involved. The disease is endemic in Asians (especially in China and Japan), 1,3,4 but rare in India, with about 200 reported cases worldwide since its histopathological diagnosis.…”

“…5 It is found almost exclusively in Asian individuals in their 2nd to 4th decade of life mostly in males (70-80%). 2,6,7,8 KD is rare in India, with about 200 reported cases worldwide since its histopathological diagnosis. 5 The disease is characterized by the triad of painless subcutaneous masses in head and neck, blood and tissue eosinophilia, and increased serum IgE levels.…”