Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Laguna, Javier; Rodríguez-García, María; Molina, Ángel; Merino, Anna

doi:10.11613/bm.2023.020801

Cited by 3 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study summarizes the clinical characteristics and radiological ndings of four patients with KD associated with mass complications. KD was most frequently observed in the head and neck, which is consistent with previous studies 10 . Other less frequent sites include the arm 11 , thigh 12 , groin 13 , breast 14 , back 5 , and et al Lee et al 5 have proposed that the male-tofemale ratio was 4.5:1, and the peak age at diagnosis was middle-aged (median: 41.35 years) for KD patients.…”

Section: Discussionsupporting

confidence: 92%

Clinical and Radiological Features of Kimura Disease: A Retrospective Case Series Study

Zhao,

Zhou,

Mao

et al. 2024

Preprint

View full text Add to dashboard Cite

This study aimed to summarize the clinical and radiologic features of KD and discuss the treatment approaches. The clinical and radiological manifestations of four histologically confirmed KD cases were analyzed. Two neuroradiologists examined the imaging data to determine the location, size, number, margin, computed tomography (CT) density, signal intensity on magnetic resonance imaging (MRI), contrast enhancement patterns, and involvement of adjacent structures. The patients consisted of three males and one female (sex ratio 3:1), and a mean age of 43 years (range, 13–71 years). The initial symptom in patients was painless subcutaneous masses with a duration ranging from 1 to 180 months. Peripheral blood eosinophilia absolute count and serum immunoglobulin E (IgE) levels were increased in 3 patients. 3 cases had multiple lesions and 1 case had a solitary lesion, the lesion regions included retroauricular (n = 2), parotid region (n = 1), submandibular gland (n = 1), maxillofacial region (n = 1), and preauricular (n = 1). Most mass margins were ill-defined and presented with diffuse subcutaneous fat atrophy around them, patients tend to present with enlarged lymph nodes with marked enhancement. KD should be considered where patients present with painless subcutaneous masses in the head and neck region, along with peripheral blood eosinophilia and elevated serum IgE levels. Given its propensity for recurrence, prolonged follow-up is required.

show abstract

Section: Discussionsupporting

confidence: 92%

Clinical and Radiological Features of Kimura Disease: A Retrospective Case Series Study

Zhao,

Zhou,

Mao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Kimura Disease: A Detailed Analysis of Clinical and Radiological Manifestations in a Retrospective Case Series

Zhao,

Zhou,

Mao

et al. 2024

JIR

View full text Add to dashboard Cite

Background Kimura disease (KD) is a rare chronic inflammatory disease that affects mainly young Asian men and is characterized by painless subcutaneous masses, lymphadenopathy, and elevated serum IgE levels. Despite its benign nature, KD poses a diagnostic and therapeutic challenge due to its rarity and clinical variability. Objective This study aimed to provide a comprehensive analysis of the clinical and radiological features of KD in a retrospective case series, to assess treatment outcomes, and to discuss the implications for diagnosis and management. Methods We retrospectively analyzed four histologically confirmed cases of KD admitted to Zhejiang Provincial People’s Hospital from January 2018 to October 2023. Clinical and radiological data were retrospectively analyzed, and imaging findings were analyzed by two neuroradiologists to determine lesion characteristics and contrast enhancement patterns. Results Our findings showed that the patients were predominantly male, with a mean age of 43 years and an age range of 13–71 years. All patients presented with painless subcutaneous masses and three of them had peripheral blood eosinophilia and elevated serum IgE levels. Radiographically, the lesions were predominantly ill-defined with heterogeneous enhancement, accompanied by subcutaneous fat atrophy. Complete surgical excision and oral corticosteroids were effective treatments, and no recurrence was noted during follow-up. Conclusion KD should be considered in the differential diagnosis of painless subcutaneous masses in the head and neck region, especially in the presence of eosinophilia and elevated IgE levels. Our findings contribute to the understanding of KD’s clinical and radiological spectrum and highlight the need for long-term follow-up due to the risk of recurrence.

show abstract

A Roadmap to Toxocariasis Infection Control: A Comprehensive Study on Its Impact, Seroprevalence, and Allergic Implications in Latin America

Silva,

Fernandes

et al. 2024

Allergies

View full text Add to dashboard Cite

This study was conducted using data from the SCAALA (Social Change Asthma and Allergy in Latin America) cohort in Brazil from 2005 to 2013. We examined the seroprevalence and risk factors of toxocariasis, a parasitic infection leading to conditions such as visceral larva migrans, utilizing an indirect ELISA with T. canis antigens, alongside with data from questionnaires, eosinophil counts, sIgE to aeroallergens, IL-10 levels, and Skin Prick Test results; the research provided insights into the disease’s dynamics. The prevalence of anti-Toxocara spp. IgG increased from 48% to 53% over the studied period, with a 25% increase in new cases in 2013. The significant risk factors included age and pet exposure, while higher maternal education and living on paved streets were found to offer protection. The study uncovered a complex interaction between Toxocara spp. infection and the immune system, indicating that the infection could both trigger inflammation and modulate skin reactions. Based on these findings, the study proposed a roadmap for controlling toxocariasis, which includes strategies such as enhancing public education about the disease and preventive measures, improving environmental sanitation, strengthening veterinary control measures like pet deworming, increasing access to healthcare and screening, and implementing community-based interventions to address the identified risk factors. These measures aim to reduce the prevalence of toxocariasis and its impact on public health by addressing environmental and socioeconomic risk factors, providing a pathway to significantly reduce the burden of this parasitic infection.

show abstract

Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Cited by 3 publications

References 18 publications

Clinical and Radiological Features of Kimura Disease: A Retrospective Case Series Study

Clinical and Radiological Features of Kimura Disease: A Retrospective Case Series Study

Kimura Disease: A Detailed Analysis of Clinical and Radiological Manifestations in a Retrospective Case Series

A Roadmap to Toxocariasis Infection Control: A Comprehensive Study on Its Impact, Seroprevalence, and Allergic Implications in Latin America

Contact Info

Product

Resources

About