Kimura Disease of the Epiglottis

AbdullGaffar, Badr; Abdul-Haleem, A.; Carlsen, Eivind

doi:10.1007/s12105-008-0078-x

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…Other sites such as the oral cavity, axilla, groin, limbs, and trunk have also been described, but the involvement of the respiratory tract is rare. To our knowledge, 10 cases of KD centered around the epiglottis have appeared in the English and Japanese literature [7][8][9][10][11][12][13][14][15][16]. Our case provides an additional example (Table 1).…”

Section: Discussionmentioning

confidence: 86%

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Yamamoto

Minamiguchi

Watanabe

et al. 2013

Head and Neck Pathol

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Kimura disease (KD) affecting an unusual site is a diagnostic challenge. We report herein the case of a 62-yearold Japanese woman who presented with swelling of the epiglottis, resulting in airway narrowing. Microscopically, biopsied and resected specimens both revealed lymphoid proliferation of a reactive immunophenotype, accompanied by vascular proliferation, eosinophilic infiltration, and stromal sclerosis. Adjunctive immunohistochemistry with immunoglobulin E in addition to laboratory and histological findings led us to seriously consider a diagnosis of KD. The patient underwent surgical removal with postoperative steroid therapy and has no evidence of recurrence. Our experience suggests that KD is potentially fatal as well as showing difficulty in the histological diagnosis when occurring in the upper respiratory tract, such as the epiglottis. A literature review disclosed that our case is the 11th case so far reported in this location, and that KD of the epiglottis did not show any male preponderance, as seen in other places.

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Section: Discussionmentioning

confidence: 86%

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Yamamoto

Minamiguchi

Watanabe

et al. 2013

Head and Neck Pathol

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“…Laryngeal lymphangiomas typically arise in the supraglottic larynx within the epiglottis, aryepiglottic folds, and arytenoid cartilages, and are hyperintense on T2-weighted MRI. 13,49 Despite the predominance in the pediatric population, Seven et al. (2004) reported a 37-year-old male who initially presented with acute epiglottitis.…”

Section: Discussionmentioning

confidence: 99%

“…While the presence of calcifications raised the possibility of a chondrosarcoma or tuberculosis, amyloidosis tends to be isointense on T1-weighted MRI and slightly hyperintense on T2-weighted MRI, while chondrosarcoma tends to be T1 hypo-or isointense and markedly T2 hyperintense. 44 Badr et al (2008) reported a case of Kimura disease, a benign chronic inflammatory disease that is likely immune driven, manifesting as a single polypoid epiglottic mass in a 37-year-old female who presented with difficulty breathing and swallowing. While usually presenting as a subcutaneous mass, the epiglottis may be involved.…”

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confidence: 99%

Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis

et al. 2015

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Epiglottic masses may be cystic, granulomatous, infectious, benign or malignant neoplastic, or manifestations of a systemic disease. When large in size, the airway may become obstructed, and when accompanied by suspicious features such as cartilaginous invasion, extension to the pre-epiglottic or para-glottic spaces, or lymphadenopathy, the radiologist must consider malignancy as a primary differential diagnosis. However, when only benign features are identified, the differential diagnosis is broad. We present a 65-year-old female with an incidental 1 cm exophytic, pedunculated, papillomatous lesion on the laryngeal surface of the epiglottis discovered upon endoscopic evaluation for dyspepsia and heartburn. Because of her risk factors for malignancy, CT scan was requested and revealed only benign features. Subsequent excisional biopsy revealed a benign squamous papilloma; however, multiple additional differential considerations were entertained preoperatively.

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“…Adjuvant therapy in the form of steroids, cytotoxic therapy, and radiation therapy also have been used in some cases. 9 Kimura’s disease is associated with excellent prognosis; only few local and distal recurrences also have been reported. 10…”

Section: Discussionmentioning

confidence: 99%

Co-existence of lip and epiglottis Kimura’s disease

Fatani

Al-Mutrafi

Al‐Qahtani

et al. 2015

SMJ

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Kimura’s disease is a rare, chronic inflammatory condition of unknown etiology; with a predilection in the head and neck region. However, the involvement of the lip and epiglottis is extremely rare, and poses a diagnostic challenge. Here, we report a case of a 32-year-old Saudi male presenting with lip mass and epiglottic swelling without any history of hoarse voice or airway compromise. Serology showed elevated immunoglobulin E levels, and histopathological examination of biopsied lesions revealed well-developed lymphoid follicles with eosinophilic infiltration confirming Kimura’s disease. At the time of last follow-up, his condition was satisfactory without any signs of recurrence.

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Kimura Disease of the Epiglottis

Cited by 10 publications

References 11 publications

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis

Co-existence of lip and epiglottis Kimura’s disease

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