Kimura Disease of the Orbit and Ocular Adnexa

Buggage, Ronald; Spraul, Christoph W.; Wojno, Ted H.; Grossniklaus, Hans E.

doi:10.1016/s0039-6257(99)00064-8

Cited by 90 publications

(118 citation statements)

References 32 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Even authoritative ophthalmic textbooks currently report ALHE and KD as being one single entity (Rubin & Jakobiec 1994;Jakobiec et al 1996). Only very recently were two cases of periocular KD reported with the purpose to separate this entity from ALHE (Buggage et al 1999). Herein we present a case of periocular ALHE with features clearly distinguishable from KD in further support of the concept that KD and ALHE are two separate entities.…”

Section: Discussionsupporting

confidence: 75%

Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura’s disease

Seregard

2001

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To emphasize the differences between angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's disease (KD), two entities often confused in the ophthalmic literature. Methods: Case report of a subcutaneous mass in the periocular region of a 45-year old woman and a MEDLINE review of the ophthalmic and non-ophthalmic literature on ALHE and KD. Results: The clinical and histopathological findings of the present case were consistent with ALHE, but not with KD. A survey of the current ophthalmic literature indicates that these two designations are still often used synonymously, despite that non-ophthalmic papers now separate ALHE from KD. Conclusion:The clinical and histopathological features of ALHE are most often distinctly different from KD and these entities should be clearly separated in the ophthalmic literature. Because of the presumed neoplastic origin ALHE has alternatively been termed epitheloid haemangioma and histiocytic haemangioma. Conversely, Kimura's disease (KD) most probably represents an allergic or autoimmune response preferentially occurring in the head and neck region of young Asian males. Because ALHE and KD share many clinical and histopathological features these lesions have repeatedly been confused and the designations used interchangeably. Overwhelming data now indicate that significant differences exist and in general pathology these entities are separated (Urabe et al. 1987;Chan et al. 1989), but in ophthalmology the original, unifying concept has largely remained unchanged. Even authoritative ophthalmic textbooks currently report ALHE and KD as being one single entity (Rubin & Jakobiec 1994;Jakobiec et al. 1996). Only very recently were two cases of periocular KD reported with the purpose to separate this entity from ALHE (Buggage et al. 1999). Herein we present a case of periocular ALHE with features clearly distinguishable from KD in further support of the concept that KD and ALHE are two separate entities. Case ReportA 45-year old Caucasian woman presented with a history of a slowly growing mass over the previous 6-8 months. Examination revealed a palpable mass located immediately superior to the medial part of the left eyebrow. Surgery was performed and a well-circumscribed subcutaneous mass was found. Following complete excision, the specimen was fixed in 4% formaldehyde and submitted for histopathological examination. There have been no signs of recurrence after a follow-up period of 18 months.The mass measured 11¿10¿7 mm in size and was cut in two halves. The cut surface disclosed a central, softer core surrounded by a rim of denser tissue. Both halves were paraffin embedded and routinely processed for light microscopy. Briefly, sections were cut at 4 mm and stained with haematoxylin and eosin, the van Gieson stain for collagen, the periodic acid-Schiff stain and Alcian blue. In addition, sections were immunostained for the CD45 (clone OPD4; product code M0742) and CD20 (clone B-Ly1; product code M0774) markers (Dako, Carpinteria, CA, USA) using the standar...

show abstract

Section: Discussionsupporting

confidence: 75%

Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura’s disease

Seregard

2001

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…10 Other unusual sites of involvement include the auricle, 11 scalp, and orbit. 12 The clinical course of Kimura's disease is generally benign and self-limited. Kimura's disease may be complicated by renal involvement.…”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease: A Diagnostic Challenge

Shetty¹,

Beaty²,

McGuirt

et al. 2002

Pediatrics

View full text Add to dashboard Cite

Kimura’s disease is a rare inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. We describe an 11-year-old Asian boy with Kimura’s disease who presented with a chronic left neck mass. The diagnosis was based on the characteristic histopathologic findings after surgical excision in conjunction with peripheral eosinophilia and elevated serum immunoglobulin E levels. Pediatricians in western countries should be aware of the clinical presentation of Kimura’s disease.

show abstract

“…Although once thought to describe different stages in the progression of the same disease, Kimura's disease (KD) and angiolymphoid hyperplasia with eosinophilia (ALHE) are now thought to be two separate disease entities [207,208]. KD is rare and characterized by subcutaneous swellings and lymphadenopathy involving head and neck soft tissue, and it is commonly seen in young Asian males [209].…”

Section: Kimura's Disease and Angiolymphoid Hyperplasia With Eosinophmentioning

confidence: 99%

“…The two conditions are distinguished based on histopathological appearance, with KD demonstrating capillary proliferation rather than proliferation of arterioles, venules, and capillaries (ALHE), and fewer follicles but more fibrosis than ALHE [207]. Within the orbit and adnexa, KD and ALHE present similarly, often with diffuse orbital mass, lacrimal gland involvement, and eyelid edema [208,[210][211][212][213][214][215][216][217][218][219][220][221].…”

Section: Kimura's Disease and Angiolymphoid Hyperplasia With Eosinophmentioning

confidence: 99%

“…Radiation therapy with or without concurrent steroid treatment has also been used successfully in refractory cases of KD [208,216,219] and ALHE [217]. In one case of ALHE not amenable to surgery due to location and infiltrative features, concurrent dosing of methotrexate and prednisone appeared to induce remission [210].…”

Section: Kimura's Disease and Angiolymphoid Hyperplasia With Eosinophmentioning

confidence: 99%

See 1 more Smart Citation