Kimura's Disease: Immunohistochemistry of Infiltrating Cells Using Monoclonal and Polyclonal Antibodies

Abstract

This study reports immunohistochemical findings with polyclonal and monoclonal antibodies in a case of Kimura's disease, angiolymphoid hyperplasia with eosinophilia, which showed a histopathology similar to that of follicular lymphoma in the initial biopsy. Major findings in our case were the variations in distribution of eosinophils, mast cells and IgE producing plasma cells between the biopsies. No proliferation of eosinophils was noted in the initial biopsy. The follicular structures in Kimura's disease appeared immunohistochemically to have derived from a reactive inflammatory process. It is suggested that the frequency of eosinophils in Kimura's disease varies with the course of the disease and that there is no direct relationship between the distributions of mast cells and eosinophils.

Kimura’s Disease with Marked Proliferation of HLA-DR⁺CD4⁺ T Cells in the Skin, Lymph Node and Peripheral Blood

“…The present case with cutaneous tumors was initially diagnosed as Kimura's disease, based on the following cri teria: (1) the clinical course was chronic and the develop ment of tumors stopped 3 years ago, suggesting a benign nature; (2) the size and localization of the tumors with peripheral leukocytosis, cosinophilia and increased IgE agreed with previous descriptions of Kimura's disease [4,5], and (3) histological examination of the tumor demon strated a picture compatible with Kimura's disease with lymphoid follicles |1], whereas mycosis cells or atypical lymphoid cells with a high nuclear contour index were not detected electron microscopically. On the other hand, it differed from a typical case of Kimura's disease in that (1) the patient's skin showed generalized atopic dermatitis-like change; (2) after attenuation of the tumors by prednisolone administration, solid papules histologically characterized by infiltrates of activated CD4' cells appeared, and (3) an increase in similar cells was also observed in the lymph node and peripheral blood.…”

Collision Dermatosis: Angiolymphoid Hyperplasia with Eosinophilia Developing within a Congenital Port Wine Nevus

“…There are features of vascular proliferation and of an inflammatory reactive process at the same time, which is confirmed by the polyclonality of the lymphoid infiltrate [7]An ALHE-acquired port-wine-stain-like lesion has been reported by Pasyk ct al. [8], However, to the best of our knowledge this is the first report on ALHE arising within a congenital port wine stain lesion.…”

Immunoglobulin heavy chain patterns in reactive lymphadenopathy.

“…For comparative purposes the diagnostic entities were subdivided into three groups: (1) benign reactive conditions (n = 24); (2) ALHE/Kimura's disease (n = 4); and (3) Hodgkin's disease (n = 3).…”