Kimura's disease with unusual eosinophilic epithelioid granulomatous reaction: A finding possibly related to eosinophil apoptosis

Hosaka, Naoki; Minato, Toshinori; Yoshida, Shinsaku; Toki, Junko; Yang, Guo‐Yu; Hisha, Hiroko; Ikehara, Susumu

doi:10.1053/hupa.2002.124037

Cited by 30 publications

(18 citation statements)

References 9 publications

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“…Another important possibility to be considered is Kimura's disease, which is associated with peripheral eosinophilia on blood counts, as in our case, and can rarely manifest an eosinophilic granulomatous reaction. 2 However, in Kimura's disease, there is a proliferation of capillaries within the stroma around the germinal centres which was not seen in our case. 3 The presence of Langerhans cells also militates against a diagnosis of Kimura's disease.…”

Section: Discussioncontrasting

confidence: 65%

“…We postulate that the formation of granulomas in our case may be the result of phagocytosis of apoptotic eosinophils by macrophages as well as host defence to the granules of the eosinophils and Charcot Leyden crystals, a situation analogous to that of a case of Kimura's disease. 2 In summary, a hitherto undescribed phenomenon of granulomatous inflammation around eosinophilic abscess in the setting of Langerhans cell histiocytosis is presented. While the granulomatous inflammation is likely to be related to the eosinophils rather than as a direct consequence of Langerhans cells, Langerhans cell histiocytosis should be carefully excluded in cases where granulomas and eosinophilic abscess are intimately related.…”

Section: Discussionmentioning

confidence: 99%

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An unusual cause of granulomatous inflammation: eosinophilic abscess in Langerhans cell histiocytosis

Tan

Chuah²,

Goh³

et al. 2006

J Clin Pathol

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Eosinophilic abscess inciting a granulomatous response has rarely been reported and appears not to have been described in the setting of a neoplasm. In this report, a case is described where a granulomatous response occurred around eosinophilic abscesses in a patient with Langerhans cell histiocytosis, an association which has not previously been documented. On histology, the excised lymph node showed the presence of eosinophilic abscess and necrosis surrounded by granulomas, which in turn were surrounded by Langerhans cells, a feature confirmed on immunohistochemistry. Although rare, this case highlights the importance of careful examination of eosinophilic abscess with granulomatous inflammation in order to exclude an underlying neoplasm.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

An unusual cause of granulomatous inflammation: eosinophilic abscess in Langerhans cell histiocytosis

Tan

Chuah²,

Goh³

et al. 2006

J Clin Pathol

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“…14 However, we did not find any polykaryocytes and the characteristic extensive fibrosis seen in KD was not present. Moreover, no extranodal extension with involvement of the perinodal soft tissue or lymphoid follicular hyperplasia as characteristically seen in KD was present.…”

Section: Discussioncontrasting

confidence: 51%

A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes

2011

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We present a patient (50-year-old male) with coexisting Warthin tumor and involvement of two intraparotid lymph nodes by Langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction. This is the second documented case of this unusual combination of histological changes in nodal Langerhans cell histiocytosis and the first case involving intraparotid lymph nodes occurring together with an ipsilateral Warthin tumor.

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“…9, protocol #1 ) using an in situ Apoptosis Detection Kit (Takara, Shiga, Japan) as previously described 48 . Morphological changes of nuclei were observed under a BZ-X700 All-In-On fluorescence microscope (Keyence, Oosaka, Japan).…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice

Liu

Wake

et al. 2017

Sci Rep

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Inflammatory processes in brain tissue have been described in human epilepsy of various etiologies and in experimental models of seizures. High mobility group box-1 (HMGB1) is now recognized as representative of damage-associated molecular patterns (DAMPs). In the present study, we focused on whether anti-HMGB1 antibody treatment could relieve status epilepticus- triggered BBB breakdown and inflammation response in addition to the seizure behavior itself. Pilocarpine and methyl-scopolamine were used to establish the acute seizure model. Anti-HMGB1 mAb showed inhibitory effects on leakage of the BBB, and on the HMGB1 translocation induced by pilocarpine. The expression of inflammation-related factors, such as MCP-1, CXCL-1, TLR-4, and IL-6 in hippocampus and cerebral cortex were down-regulated by anti-HMGB1 mAb associated with the number of activated astrocytes, microglial cells as well as the expression of IL-1β. Both hematoxylin & eosin and TUNEL staining showed that the apoptotic cells could be reduced after anti-HMGB1 mAb treatment. The onset and latency of Racine stage five were significantly prolonged in the anti-HMGB1 mAb group. These results suggested that anti-HMGB1 mAb prevented the BBB permeability, reduced HMGB1 translocation while inhibiting the expression of inflammation-related factors, protected against neural cell apoptosis and prolonged Racine stage 5 seizure onset and latency.

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Kimura's disease with unusual eosinophilic epithelioid granulomatous reaction: A finding possibly related to eosinophil apoptosis

Cited by 30 publications

References 9 publications

An unusual cause of granulomatous inflammation: eosinophilic abscess in Langerhans cell histiocytosis

An unusual cause of granulomatous inflammation: eosinophilic abscess in Langerhans cell histiocytosis

A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes

Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice

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