KIN enhances stem cell-like properties to promote chemoresistance in colorectal carcinoma

Yu, Miao; Zhang, Zhenwei; Yu, Honglan; Xue, Conglong; Yuan, Kaitao; Miao, Mingyong; Hanping, Shi

doi:10.1016/j.bbrc.2014.04.057

Cited by 5 publications

(5 citation statements)

References 37 publications

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“…Further analysis revealed that upregulation of KIN17 was significantly correlated with advanced tumor grade and lymph node metastasis. Similar results have been reported by Yu et al ( 10 ). The results of the present study suggest that patients with elevated KIN17 expression have a poorer prognosis, and that KIN17 is a potential diagnostic and prognostic biomarker for NSCLC.…”

Section: Discussionsupporting

confidence: 93%

“…At present, the expression level of KIN17 in human tumors remains unclear. Recently, studies performed by Yu et al ( 10 ) and Kou et al ( 9 ) revealed that KIN17 gene expression is upregulated in colorectal cancer and hepatocellular carcinoma, respectively. In addition, a previous study demonstrated that KIN17 was markedly overexpressed in breast cancer ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…Emerging evidence has indicated the importance of Kin17 in the pathogenesis and progression of tumors. Previous studies have reported that KIN17 expression is elevated in colon cancer, hepatocellular carcinoma and breast cancer ( 8 – 10 ). In addition, previous studies have revealed that the upregulation of KIN17 is associated with proliferation, chemoresistance and radioresistance in tumors ( 5 , 11 , 12 ).…”

Section: Introductionmentioning

confidence: 97%

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Upregulation of KIN17 is associated with non-small cell lung cancer invasiveness

et al. 2017

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Kin17 DNA and RNA binding protein (Kin17) is a highly conserved protein that participates in DNA replication, DNA repair and cell cycle progression. Recently, the tumor-promoting function of Kin17 has been demonstrated and increasingly studied. In the present study, the role of Kin17 in the invasion and metastasis of non-small cells lung cancer (NSCLC) was investigated. Elevated Kin17 mRNA and protein expression was identified in a total of 97 NSCLC and benign lung lesion tissue specimens. Kin17 overexpression was significantly correlated with high tumor grade and lymph node metastasis, indicating poor patient prognosis. Scratch and Transwell assays demonstrated that the knockdown of KIN17 inhibited the ability of NSCLC cells to migrate and invade. Furthermore, reverse transcription-quantitative polymerase chain reaction and western blot analyses confirmed that knockdown of KIN17 decreased the expression of matrix metalloproteinase 7, epidermal growth factor receptor and v-myc avian myelocytomatosis viral oncogene homolog. The results of the present study indicate that Kin17 is markedly overexpressed in NSCLC tissues compared with benign lung lesion and peritumoral tissue. The upregulation of KIN17 may serve an important role in the metastasis of NSCLC cells. These results indicate that Kin17 is a novel diagnostic and prognostic biomarker of NSCLC, in addition to being a potential therapeutic target for the treatment of patients with NSCLC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Upregulation of KIN17 is associated with non-small cell lung cancer invasiveness

et al. 2017

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“…KIN is described as a potential diagnostic biomarker and a potential target for breast cancer therapy [1,2], as well as a suitable marker for predicting chemotherapy response in colorectal carcinoma [3]. A study recently performed and published by our group demonstrated that KIN is differently expressed in subpopulations of melanoma from murine cell lines, according to its aggressiveness [4].…”

Section: Introductionmentioning

confidence: 99%

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein

Gaspar

Ramos

Cloutier

et al. 2021

CIMB

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KIN (Kin17) protein is overexpressed in a number of cancerous cell lines, and is therefore considered a possible cancer biomarker. It is a well-conserved protein across eukaryotes and is ubiquitously expressed in all cell types studied, suggesting an important role in the maintenance of basic cellular function which is yet to be well determined. Early studies on KIN suggested that this nuclear protein plays a role in cellular mechanisms such as DNA replication and/or repair; however, its association with chromatin depends on its methylation state. In order to provide a better understanding of the cellular role of this protein, we investigated its interactome by proximity-dependent biotin identification coupled to mass spectrometry (BioID-MS), used for identification of protein–protein interactions. Our analyses detected interaction with a novel set of proteins and reinforced previous observations linking KIN to factors involved in RNA processing, notably pre-mRNA splicing and ribosome biogenesis. However, little evidence supports that this protein is directly coupled to DNA replication and/or repair processes, as previously suggested. Furthermore, a novel interaction was observed with PRMT7 (protein arginine methyltransferase 7) and we demonstrated that KIN is modified by this enzyme. This interactome analysis indicates that KIN is associated with several cell metabolism functions, and shows for the first time an association with ribosome biogenesis, suggesting that KIN is likely a moonlight protein.

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“…Kin17 is overexpressed in breast cancer (8), liver cancer (9), and chronic myelogenous leukemia cell line K562 (10) and can stimulate tumor cell proliferation. CRC cell lines highly expressing kin17 have shown resistance to chemotherapeutic drugs such as oxaliplatin and 5-fluorouracil that act on DNA and make tumor cells acquire stem-like attributes (11). Therefore, it is of great significance to further explore the expression of kin17 in CRC and its relationships with clinical pathological parameters.…”

Section: Introductionmentioning

confidence: 99%

Relationships of kin17 protein expression with clinical features and prognosis of colorectal cancer

Ruan¹,

Jiang²,

Zhang³

2018

Transl. Cancer Res

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KIN enhances stem cell-like properties to promote chemoresistance in colorectal carcinoma

Cited by 5 publications

References 37 publications

Upregulation of KIN17 is associated with non-small cell lung cancer invasiveness

Upregulation of KIN17 is associated with non-small cell lung cancer invasiveness

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein

Relationships of kin17 protein expression with clinical features and prognosis of colorectal cancer

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