The eccentric rolling transmission consists of rolling bearings mounted eccentrically on the input shaft, cooperating with cam wheels, which are mounted on the output shaft. The aim of this paper was to determine the sensitivity of the transmission to the manufacturing errors of the cam wheel. Two methods of cam wheels milling using a universal CNC machining center were proposed. The measurements of manufactured wheels were performed using a blue light 3D scanner, which allowed the determination of geometric dimensions and deviations from nominal geometry. The experimental research of the eccentric rolling transmission prototype equipped with manufactured cam wheels was conducted, measuring the torque on the gear shafts as a function of its angular position. On the basis of the obtained results, the impact of manufacturing errors on the operation of the transmission unit was examined, especially in terms of torque and efficiency. It was indicated that the machining using ball nose end mill ensures sufficient accuracy of the cam wheels.