Kinematic analysis of the reach to grasp movement in Parkinsons and Huntingtons disease subjects

Bonfiglioli, Claudia; Berti, Gianni De; Nichelli, Paolo Frigio; Nicoletti, Roberto; Castiello, Umberto

doi:10.1016/s0028-3932(97)00171-1

Cited by 38 publications

(18 citation statements)

References 14 publications

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“…6,7,11 However, the slowness seems to be dependent on the types of tasks being performed, the speed at which the task is performed, or the amplitude of movement. 12,13 In the present study, subjects with HD had an overall slowness of movement, as defined from the onset of gripping the object to the release. However, when the movement was further analyzed, slowness was evident in specific components of the movement, establishing contact with the object and sequencing of the grip-lift phases.…”

Section: Bradykinesiamentioning

confidence: 72%

“…20,21 Several studies have reported that individuals with HD have slowness of movement while performing rapid (as fast as possible) upper extremity movements. 6,7,13 Bonfiglioli et al 13 found that HD patients had prolonged reach-to-grasp movements compared to control subjects when performing the task as fast as possible, but not when self-paced. In the present study, subjects moved at a self-selected pace, and specific aspects of their movement were prolonged.…”

Section: Bradykinesiamentioning

confidence: 99%

“…During rapid pointing movements, subjects with HD demonstrated bradykinesia, with prolonged deceleration phases as they honed in on a target. 11 Similarly, Bonfiglioli et al 13 found that reach-to-grasp movements were prolonged when performed as fast as possible, though not at a self-selected pace. During precision grasping and lifting of objects, subjects with HD also had prolonged task performance times.…”

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confidence: 97%

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Altered movement trajectories and force control during object transport in Huntington's disease

et al. 2001

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Individuals with Huntington's Disease (HD) have difficulty grasping and transporting objects, however, the extent to which specific impairments affect their performance is unknown. The present study examined the kinematics and force coordination during transport of an object in 12 subjects with HD and 12 age-matched controls. Subjects grasped an object between their thumb and index finger, transported it 25 cm forward, replaced and released it while their fingertip forces and the object's position were recorded. Five trials were performed with each of three weights (200 g, 400 g, and 800 g). While bradykinesia was evident in subjects with HD, this slowness was not consistently observed in all phases of the movement. The slowness of movement seen during the task appears to be due to impairments in sequencing and the movement strategies selected by the subjects. Compared to control subjects, subjects with HD produced highly curvilinear hand paths and more variable grip forces that were dependent on the weight of the object. Isometric force development and movement speed during transport were unaffected by the disease. The results suggest that prolonged task durations in subjects with HD are not necessarily due to slowness of movement, per se. These findings have clinical implications for understanding the task-specific nature of movement impairments in HD and developing effective intervention strategies.

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Section: Bradykinesiamentioning

confidence: 72%

Section: Bradykinesiamentioning

confidence: 99%

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confidence: 97%

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Altered movement trajectories and force control during object transport in Huntington's disease

et al. 2001

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“…1). This variability in the neuroleptic bradykinesia model (Hauber and Schmidt, 1990;Mayfield et al, 1993;Hauber, 1996) is akin to the variability seen in human Parkinsonian bradykinesia, in which individual subject movement-speed distributions overlap with age-matched control data (Bonfiglioli et al, 1998;Poizner et al, 2000). However, because the experimental variation could represent slight differences in effective dosage (e.g., different uptake kinetics resulting from intraperitoneal injection into peritoneal fat), we included only cases of unambiguous drug-induced bradykinesia in the analysis.…”

Section: Haloperidol-induced Bradykinesiamentioning

confidence: 99%

Bradykinesia Induced by Dopamine D2 Receptor Blockade Is Associated with Reduced Motor Cortex Activity in the Rat

Parr‐Brownlie

Hyland²

2005

Journal of Neuroscience

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Disruption of motor cortex activity is hypothesized to play a major role in the slowed movement (bradykinesia) associated with reduced dopaminergic function. We recorded single neurons in the motor cortex of free-moving rats performing a forelimb-reaching task. The same neurons were examined before and after induction of bradykinesia with the D 2 dopamine receptor antagonist haloperidol. Withincell changes in the firing rate and firing pattern of individual cells and the correlation between simultaneously recorded cells after injection of haloperidol were statistically compared with vehicle-only control experiments. During haloperidol-induced bradykinesia (mean movement time increase, ϩ231%), there was an average 11% decrease in baseline firing rate. Movement-related peaks in firing rate were more dramatically affected, with an overall reduction in peak amplitudes of 40%. Bradykinesia was also associated with decreased intensity of bursting and amplitude of cross-correlation peaks at rest. The results show for the first time that significant reductions can be detected in motor cortex activity at rest in animals with impaired ability to generate movements induced by reduced dopamine action and confirm that impaired movements are associated with reduced cortical activation. Together, these changes in neural activity may reduce recruitment and rate modulation of motor units in the spinal cord.

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“…This disease causes adult-onset progressive motor, cognitive, and psychiatric symptoms [13], including abnormalities in reaching movement kinematics [14], sensorimotor error correction [15], motor skill learning [16], and simultaneous performance of multiple tasks [17], dividing attention [18], and explicit learning of motor sequences [19]. We considered the possibility that impaired segregation of sensorimotor signals constitutes a low-level deficit that could contribute to some of these impairments.…”

Section: Introductionmentioning

confidence: 99%

Parallel Explicit and Implicit Control of Reaching

Mazzoni

Wexler

2009

PLoS ONE

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BackgroundHuman movement can be guided automatically (implicit control) or attentively (explicit control). Explicit control may be engaged when learning a new movement, while implicit control enables simultaneous execution of multiple actions. Explicit and implicit control can often be assigned arbitrarily: we can simultaneously drive a car and tune the radio, seamlessly allocating implicit or explicit control to either action. This flexibility suggests that sensorimotor signals, including those that encode spatially overlapping perception and behavior, can be accurately segregated to explicit and implicit control processes.Methodology/Principal FindingsWe tested human subjects' ability to segregate sensorimotor signals to parallel control processes by requiring dual (explicit and implicit) control of the same reaching movement and testing for interference between these processes. Healthy control subjects were able to engage dual explicit and implicit motor control without degradation of performance compared to explicit or implicit control alone. We then asked whether segregation of explicit and implicit motor control can be selectively disrupted by studying dual-control performance in subjects with no clinically manifest neurologic deficits in the presymptomatic stage of Huntington's disease (HD). These subjects performed successfully under either explicit or implicit control alone, but were impaired in the dual-control condition.Conclusion/SignificanceThe human nervous system can exert dual control on a single action, and is therefore able to accurately segregate sensorimotor signals to explicit and implicit control. The impairment observed in the presymptomatic stage of HD points to a possible crucial contribution of the striatum to the segregation of sensorimotor signals to multiple control processes.

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Kinematic analysis of the reach to grasp movement in Parkinsons and Huntingtons disease subjects

Cited by 38 publications

References 14 publications

Altered movement trajectories and force control during object transport in Huntington's disease

Altered movement trajectories and force control during object transport in Huntington's disease

Bradykinesia Induced by Dopamine D2 Receptor Blockade Is Associated with Reduced Motor Cortex Activity in the Rat

Parallel Explicit and Implicit Control of Reaching

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