“…Existing studies report that specific implant design features are able to guide joint motion (Gray et al, 2020;SchĂŒtz et al, 2019b;Scott et al, 2016), with considerable inter-subject variability presented for less constrained designs (SchĂŒtz et al, 2019b), possibly due to the additional role of surgical implantation parameters and soft-tissue sufficiency. However, only a limited number of studies have directly compared tibio-femoral kinematics during functional gait activities in natural and replaced knees using a consistent measurement set-up, as well as analysis approach (Dennis et al, 2001;Ghirardelli et al, 2021;Gray et al, 2020;Miura et al, 2020). Independent of the implant design, more tibial external rotation has been observed for the TKR subjects compared to natural knees over the course of a gait cycle, especially during late stance and early swing phases (Gray et al, 2020;Miura et al, 2020).…”