Kinematics of treadmill locomotion in mice raised in hypergravity

Bojados, Mickael; Herbin, Marc; Jamon, Marc

doi:10.1016/j.bbr.2013.01.017

Cited by 21 publications

(20 citation statements)

References 49 publications

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“…Consistently, previous studies on the effects of altered gravity on the development of motor functions have shown enduring changes in locomotion (Bojados et al 2013;Walton et al 1992), swimming behavior (Walton et al 2005a), and development of surface righting (Walton et al 2005b) and thus suggested the existence of a critical period in motor development. Persisting extension bias was observed by Bojados et al (2013) in 2-mo-old mice centrifuged from conception to P10 or P30. In addition, rats born and reared until the age of 3 mo in HG were found to exhibit a lower body position, an enlarged support surface, and an exaggerated foot dorsiflexion (Bouët et al 2003(Bouët et al , 2004.…”

supporting

confidence: 82%

“…Changes in gravity induce alteration in joint and muscle proprioception (McCall et al 2003). Consistently, HG during early development has been shown to modify postural control and locomotion in rodents (Bojados et al 2013). Therefore, we hypothesized that HG, by modifying the pressure exerted on the ventral surfaces of the paws and muscle spindle stimulation, thereby changing the pattern of cutaneous and proprioceptive inputs to the S1 cortex compared with normogravity, would shape the topographical organization of the forepaw maps in a distinctive way.…”

mentioning

confidence: 85%

“…HG has been shown to affect the development of the vestibular (Ross and Tomko 1998) and motor systems (Brocard et al 2003) and their functions such as air righting during free fall, locomotion, postural control, and limb movement when the HG animals were subsequently exposed to normogravity (Bojados et al 2013;Bouët et al 2003Bouët et al , 2004. The enduring motor changes found in rats that grew up in altered gravity stress the key role of gravity during the motor development and suggest the existence of critical periods (Walton et al 1992).…”

mentioning

confidence: 99%

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Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult

Zennou-Azogui

Catz

Xerri

2016

Journal of Neurophysiology

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Zennou-Azogui Y, Catz N, Xerri C. Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult. J Neurophysiol 115: 2740 -2760, 2016. First published February 17, 2016 doi:10.1152/jn.00900.2015.-We investigated experience-dependent plasticity of somatosensory maps in rat S1 cortex during early development. We analyzed both short-and long-term effects of exposure to 2G hypergravity (HG) during the first 3 postnatal weeks on forepaw representations. We also examined the potential of adult somatosensory maps for experience-dependent plasticity after early HG rearing. At postnatal day 22, HG was found to induce an enlargement of cortical zones driven by nail displacements and a contraction of skin sectors of the forepaw map. In these remaining zones serving the skin, neurons displayed expanded glabrous skin receptive fields (RFs). HG also induced a bias in the directional sensitivity of neuronal responses to nail displacement. HG-induced map changes were still found after 16 wk of housing in normogravity (NG). However, the glabrous skin RFs recorded in HG rats decreased to values similar to that of NG rats, as early as the end of the first week of housing in NG. Moreover, the expansion of the glabrous skin area and decrease in RF size normally induced in adults by an enriched environment (EE) did not occur in the HG rats, even after 16 wk of EE housing in NG. Our findings reveal that early postnatal experience critically and durably shapes S1 forepaw maps and limits their potential to be modified by novel experience in adulthood. cortex; development; critical period; electrophysiological mapping; forepaw EXPERIENCE-DEPENDENT SHAPING of morphological and functional brain circuits leads to appropriately organized neural networks that subserve adult brain functions. The effect of the so-called epigenetic factors is most prominent within postnatal

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confidence: 82%

mentioning

confidence: 85%

mentioning

confidence: 99%

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Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult

Zennou-Azogui

Catz

Xerri

2016

Journal of Neurophysiology

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“…The first notion of the cyclogram claimed that a cyclic process such as walking is better understood when studied with a cyclic plot [5]. The creation of cyclograms is based on joint angles that are objective and well suited for statistical study of the different aspects of movement [6][7][8]. Some authors also described cyclograms based on paths of the segments (e.g.…”

Section: Introductionmentioning

confidence: 99%

Analysis and prediction of upper extremity movements by cyclograms

2014

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AbstractQuantification of upper extremity movement is a common objective in both research and clinical practice. Currently, methods based on angle-angle diagrams, also called cyclograms, seem to be promising. Nevertheless, compared to the study of lower limbs, the concept of angle-angle diagrams has not been systematically used to study upper limb movements during walking. The paper describes two examples of new methods based on angle-angle diagrams for application in rehabilitation and assistive robotics. The cyclograms represent information about the relationship between the angles and their changes over time. We used cyclograms as patterns for learning artificial neural networks and predicting the movement of upper-limb. Together with artificial intelligence, cyclograms offer wide scope of application in prosthesis control systems. Using bilateral cyclogram, the information about the relationship between the right and left arm joint angles is used to evaluate the symmetry of movements. The method based on the orientation of the bilateral cyclogram can be used as an additional method for determining the symmetry of movements of the upper limbs or exo-prosthesis.

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“…Recent VOR and locomotor experiments on mice have shown that VOR responses were generally less affected than posture or locomotion ( Bojados and Jamon, 2011;Bojados et al, 2013). Hence, only the animals exposed for the entire developmental period showed changes in VOR responses, whereas postural or locomotor deficits were found in groups exposed during limited periods of development.…”

Section: Effects On Vestibulo-ocular Reflexmentioning

confidence: 95%