2024
DOI: 10.1096/fj.202400989r
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Kinesin motor KIF16A regulates microtubule stability and actin‐dependent spindle migration in mouse oocyte meiosis

Wei Wang,
Zhenhu Shi,
Dandan Zhang
et al.

Abstract: Kif16A, a member of the kinesin‐3 family of motor proteins, has been shown to play crucial roles in inducing mitotic arrest, apoptosis, and mitotic cell death. However, its roles during oocyte meiotic maturation have not been fully defined. In this study, we report that Kif16A exhibits unique accumulation on the spindle apparatus and colocalizes with microtubule fibers during mouse oocyte meiotic maturation. Targeted depletion of Kif16A using gene‐targeting siRNA disrupts the progression of the meiotic cell cy… Show more

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