Kinesiotherapy for quality of life, pain and muscle strength of rheumatoid arthritis and systemic lupus erythematosus patient. Case report

Myra, Rafaela Simon; DeMarco, Mariângela; Zanin, Caroline; Wibelinger, Lia Mara

doi:10.5935/1806-0013.20150029

Cited by 2 publications

(1 citation statement)

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“…After all, with the physiotherapeutic approach it is possible to achieve the promotion of functional gains, the repair of sleep, analgesia, reduction of fatigue, among other results that together culminate in the improvement in the quality of life of the affected individuals. [2][3][4] Although its pathogenesis is not very elucidated yet, FM seems to be related to inflammatory pathways and neurochemical alterations in the brain, amplifying the painful sensation with increased and decreased signaling in descending neural pathways. In addition, FM bearing patients present a reduced threshold of other sensory stimuli such as heat, cold, auditory, and electrical stimuli.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ApaI and FokI polymorphism of VDR gene and functional characterization in patients with fibromyalgia

et al. 2022

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Introduction: Fibromyalgia (FM) is a syndrome of unknown origin characterized by several symptoms, and although its pathogenesis has not been completely elucidated, it seems to be related to inflammatory path-ways and neurochemical changes in the brain. Objective: To evaluate the association between BsmI, ApaI and FokI polymorphisms of the vitamin D receptor (VDR) gene, their polymorphisms, and clinical variables in women with and without FM. Methods: This is a case-control study composed of a group of 53 women with FM and another with 40 women without the disease. The McGill Pain Questionnaire, Fibromyalgia Impact Questionnaire, Pain Visual Analogue Scale and the sit-up test were applied. Real-time PCR was performed to analyze the ApaI and FokI polymorphism. Results: There was a statistical association between race, comorbidity and FM, where 78.4% of the individuals were white and had FM (p < 0.002) and 96.1% had some comorbidity (p < 0.001). Seventy-six point five percent (76.5%) of patients with FM underperformed in the sit-up test (p < 0.001). There was also an association between the genotypic and allele frequencies of the VDR and FM gene Apal and FokI polymorphisms (p < 0.001). In the VDR gene ApaI polymorphism, the CC genotype exhibited a higher frequency in women with FM, the C allele for the Apal polymorphism was 3.33 times more likely, and the FokI polymorphism was 10.9 times more likely to develop FM (p < 0,0001). Conclusion: Women with C allele for ApaI polymorphism are 3.33 times more likely to have FM (95%CI = 1.58-7.02; p = 0.0024), and in FokI polymorphism, the prevalence of T allele is 10.9 times greater (95% CI = 4.76-25.38; p < 0.0001). No significant associations were found in relation to BsmI polymorphism and frequency alleles (p = 0.062 and p = 0.078, respectively).

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Section: Introductionmentioning

confidence: 99%