Kinetic analysis of competing intramolecular and intermolecular polymerization reactions

Noureddini, Hossein; Timm, D. C.

doi:10.1021/ma00032a016

Cited by 19 publications

(20 citation statements)

References 7 publications

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“…For instance, a simultaneous synthesis of two different carbon-11 tracers ([ 11 C]DASB and [ 11 C]methionine) was published by Lee et al 10 describing [ 11 C]CH 3 I production in one cyclotron run, further split to two different loops loaded with the respective precursor. Such simultaneous, but separated, radiochemical reactions have also been reported for other radiotracers 11 , 12 . To the best of our knowledge, the introduction of [ 11 C]CH 3 I in a solution containing two precursors has not been described so far.…”

Section: Introductionsupporting

confidence: 69%

Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

Vraka

Murgaš

Rischka

et al. 2022

Sci Rep

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Simultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the relevance for human application. [11C]harmine and [11C]DASB were concurrently synthesized in a ‘two-in-one-pot’ reaction in quality for application. Dual-tracer protocol was simulated using 16 single PET scans in different orders of tracer application separated by different time intervals. Volume of distribution was calculated for single- and dual-tracer measurements using Logan’s plot and arterial input function in 13 brain regions. The ‘two-in-one-pot’ reaction yielded equivalent amounts of both radiotracers with comparable molar activities. The simulations of the dual-tracer application were comparable to the single bolus injections in 13 brain regions, when [11C]harmine was applied first and [11C]DASB second, with an injection time interval of 45 min (rxy = 0.90). Our study shows the successful simultaneous dual-tracer production leading to decreased radiation burden and costs. The simulation of dual subject injection to quantify the monoamine oxidase-A and serotonin transporter distribution proved its high potential. Multi-tracer imaging may drive more sophisticated study designs and diminish the day-to-day differences in the same individual as well as increase PET scanner efficiency.

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Section: Introductionsupporting

confidence: 69%

Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

Vraka

Murgaš

Rischka

et al. 2022

Sci Rep

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“…We assumed no intramolecular reactions thus no cycles can form on oligomers. Several authors have proposed polymerization systems with intramolecular reactions involving one [7,23,24] or two [25] monomer species, and find that cycle formation affect the sol-gel transition time.…”

Section: Discussionmentioning

confidence: 99%

Kinetic model of two-monomer polymerization

2020

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We propose a kinetic gelation model of polymer growth with two monomeric types that have distinct functionalities (reaction sites), and can polymerize using different reaction types. The heterotypic aggregation of two monomer types is modeled using a moment generating function approach by tracking the temporal evolution of a closed system of moment equations up until gelation. We investigate several scenarios of polymerization with two distinct monomers that differ in the types of reactions that can occur. We determine numerical and analytical conditions for finite time blow-up (the emergence of an oligomer of infinite size) that depend on initial conditions, reaction rates, and number of reaction sites per monomer.

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“…Some linear oligomers tend to form cyclic oligomers through end‐biting reactions wherein the functional groups at the two ends of the same molecule react with each other. The presence of linear and cyclic oligomers may lead to a broad molecular weight distribution (MWD) . Knowledge about linear and cyclic oligomer formation is important in condensation polymerization processes for polyesters, polyamides, polycarbonates, polyketones, polyether ketones, polysulfones, polysulfides, and polysiloxanes, as well as in many block copolymers .…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Polyether Production from 1,3‐Propanediol: Accounting for Linear Oligomers

McAuley

Spence

Xie

2015

Macro Reaction Engineering

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A mathematical model is developed to simulate the production of bio-based polytrimethylene ether glycol (PO3G) using 1,3-propanediol. The effect of super-acid catalyst is accounted for in the model, as is mass transfer of small species (water, monomer, and propanal) and linear oligomers (dimer to heptamer). This model correctly predicts dynamic trends in concentrations of linear oligomers, but the predicted maxima in these concentrations appear slightly earlier than in the experimental data. Predictions of the degree of polymerization (DP) are improved compared with those from a previous model, where evaporation of linear oligomers was not considered. Additional model improvements, including account

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Kinetic analysis of competing intramolecular and intermolecular polymerization reactions

Cited by 19 publications

References 7 publications

Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

Kinetic model of two-monomer polymerization

Mathematical Modeling of Polyether Production from 1,3‐Propanediol: Accounting for Linear Oligomers

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