2015
DOI: 10.1007/s10973-015-4842-3
|View full text |Cite
|
Sign up to set email alerts
|

Kinetic analysis of solid-state degradation of pure pravastatin versus pharmaceutical formulation

Abstract: In this paper, the kinetic behavior of decomposition of a well-known bioactive substance used for treating dyslipidemia and the prevention of cardiovascular disease drug from statin class, namely pravastatin, was described. The kinetic study was performed on the main decomposition process which occurs at nearly 200°C, for both pure active substance and a generic commercial formulation that contain 40 mg pravastatin per tablet, using Kissinger, Friedman, Kissinger-Akahira-Sunose, FlynnWall-Ozawa and NPK methods… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
14
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 26 publications
(14 citation statements)
references
References 25 publications
0
14
0
Order By: Relevance
“…Starch is frequently used as an excipient and often a similar thermal behavior like the one of MCel is observed when used in a mixture with a pharmaceutical agent [13][14][15]. Indeed, a similar structure, a polysaccharide molecule, leads to a compatible thermodegradation in the same temperature range, and this is obvious by comparison of the HF curves corresponding to MCel in Fig.…”
Section: Resultsmentioning
confidence: 90%
See 1 more Smart Citation
“…Starch is frequently used as an excipient and often a similar thermal behavior like the one of MCel is observed when used in a mixture with a pharmaceutical agent [13][14][15]. Indeed, a similar structure, a polysaccharide molecule, leads to a compatible thermodegradation in the same temperature range, and this is obvious by comparison of the HF curves corresponding to MCel in Fig.…”
Section: Resultsmentioning
confidence: 90%
“…According to [5] and some of our previous papers [11][12][13][14][15][16], the thermal behavior of these binary mixtures was studied under non-isothermal conditions in order to detect the thermally induced interactions.…”
Section: Introductionmentioning
confidence: 99%
“…Another feature is when T is close to T 0 , E value should be infinity. [27][28][29][30][31] is: Figure 4b shows the Friedman plots for the pure VO 2 at a = 0.5 around the T p . Two plots demonstrate nonlinear plots of similar shape.…”
Section: Resultsmentioning
confidence: 99%
“…5, 10 and 20°C was obtained in DTG curves (5-95 %). In addition, the kinetic parameters can be conventionally expressed with the extent of triplet TG curves, because three or more curves contribute to the measured data and also to reproduce the kinetic data [12][13][14][15][16][18][19][20][21]. The values of the correlation coefficient (r) and activation energy (E a ) are listed in Table 1.…”
Section: Kinetic Methodologymentioning
confidence: 99%