Kinetic analysis of β-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing

Hu, Wenyuan; Chang, Guan‐Liang; Chen, Shean Jen; Kuo, Yu Min

doi:10.1016/j.jneumeth.2005.12.016

Cited by 60 publications

(44 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Smith et al (2007) stated this could be a secondary effect caused by, for example, increased heme oxygenase activity in response to oxidative stress (Schipper, 2004). This could be further strengthened by the fact that, despite being found to interact with Ab in vitro (Hu et al 2006), Fe does not copurify with Ab extracted from plaques (Opazo et al 2002). Most recently, other pathways have been explored; in particular, it has been assumed that Fe could directly influence Ab production through the modulation of furin, a ubiquitous enzyme, whose proteolytic activity is required for many cellular processes, including a-and c-secretase processing.…”

Section: Ironmentioning

confidence: 99%

Metal Ion Physiopathology in Neurodegenerative Disorders

2009

View full text Add to dashboard Cite

Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the biochemical mechanisms of metal involvement in NDs is still largely unknown. Mounting evidence suggests that normal aging itself is characterized by, among other features, a significant degree of metal ion dysmetabolism in the brain. This is probably the result of a progressive deterioration of the metal regulatory systems and, at least in some cases, of life-long metal exposure and brain accumulation. Although alterations of metal metabolism do occur to some extent in normal aging, they appear to be highly enhanced under various neuropathological conditions, causing increased oxidative stress and favoring abnormal metal-protein interactions. Intriguingly, despite the fact that most common NDs have a distinct etiological basis, they share striking similarities as they are all characterized by a documented brain metal impairment. This review will primarily focus on the alterations of metal homeostasis that are observed in normal aging and in Alzheimer's disease. We also present a brief survey on BMD in other NDs (Amyotrophic Lateral Sclerosis, Parkinson's, and Prion Protein disease) in order to highlight what represents the most reliable evidence supporting a crucial involvement of metals in neurodegeneration. The opportunities for metal-targeted pharmacological strategies in the major NDs are briefly outlined as well.

show abstract

Section: Ironmentioning

confidence: 99%

Metal Ion Physiopathology in Neurodegenerative Disorders

2009

View full text Add to dashboard Cite

show abstract

“…The kinetics of amyloid aggregation (from monomers to fibrils) and also the effect(s) of metal ions in the case of aggregation process were also extensively investigated [18][19][20][21]. Interactions between gold surfaces-immobilized A␤-peptides and gangliosides [22], flavonoids [23], tau-protein [17] and alcohol dehydrogenase [24] were also studied in previous literatures.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of gold nanoparticles with amino acid, β-amyloid peptides and fragment

Majzik

Fülöp

Csapó

et al. 2010

Colloids and Surfaces B: Biointerfaces

126

View full text Add to dashboard Cite

“…Subsequently, PBS solution was again introduced to flow channels for 13 min to obtain the final reaction amount from the specific binding of the aptamer and PSA. The affinity and kinetic parameters of aptamer-protein interactions were obtained by using two mathematical equations based on the first-order kinetics model for fitting SPR sensorgrams [20, 25]. From the calculation, the association rate constant k a and the dissociation rate constant k d can be determined.…”

Section: Methodsmentioning

confidence: 99%

The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen

Hsieh

Lin

Chen

et al. 2017

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Herein, we report a method of combining bioinformatics and biosensing technologies to select aptamers against prostate specific antigen (PSA). The main objective of this study is to select DNA aptamers with higher binding affinity for PSA by using the proposed method. Based on the five known sequences of PSA-binding aptamers, we adopted the functions of reproduction and crossover in the genetic algorithm to produce next-generation sequences for the computational and experimental analysis. RNAfold web server was utilized to analyze the secondary structures, and the 3-dimensional molecular models of aptamer sequences were generated by using RNAComposer web server. ZRANK scoring function was used to rerank the docking predictions from ZDOCK. The biosensors, the quartz crystal microbalance (QCM) and a surface plasmon resonance (SPR) instrument, were used to verify the binding ability of selected aptamer for PSA. By carrying out the simulations and experiments after two generations, we obtain one aptamer that can have the highest binding affinity with PSA, which generates almost 2-fold and 3-fold greater measured signals than the responses produced by the best known DNA sequence in the QCM and SPR experiments, respectively.

show abstract

Kinetic analysis of β-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing

Cited by 60 publications

References 42 publications

Metal Ion Physiopathology in Neurodegenerative Disorders

Metal Ion Physiopathology in Neurodegenerative Disorders

Functionalization of gold nanoparticles with amino acid, β-amyloid peptides and fragment

The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen

Contact Info

Product

Resources

About